| 0 | - | cover | 1 | pencils: Mike Mignola; inks: Mike Mignola; colors: Matt Hollingsworth; letters: Kevin Nowlan | Hellboy, Grigori Rasputin |
| 1 | Mike Mignola's Hellboy: Seed of Destruction | credits, title page | 2 | pencils: Mike Mignola; inks: Mike Mignola | |
| 2 | - | illustration | 1 | pencils: Mike Mignola; inks: Mike Mignola | Hellboy |
| 3 | Credits | credits, title page | 1 | letters: typeset | |
| 4 | Publication Data | credits, title page | 1 | letters: typeset | |
| 5 | Introduction | foreword, introduction, preface, afterword | 1 | script: Robert Bloch; pencils: Mike Mignola; inks: Mike Mignola | |
| 6 | Dedication | foreword, introduction, preface, afterword | 1 | script: Mike Mignola | |
| 7 | Chapter One | illustration | 1 | pencils: Mike Mignola; inks: Mike Mignola | |
| 8 | Hellboy: Seed of Destruction #1 Cover | cover reprint (on interior page) | 1 | pencils: Mike Mignola, Arthur Adams; inks: Mike Mignola, Arthur Adams | Hellboy, Monkeyman, Ann O'Brien, Axwell Tiberius |
| 9 | Seed of Destruction Chapter One | comic story | 23 | script: Mike Mignola, John Byrne; pencils: Mike Mignola; inks: Mike Mignola; colors: Mark Chiarello; letters: John Byrne, Mike Mignola | Trevor Bruttenholm, Cynthia Eden-Jones, Malcolm Frost, Ilsa Haupstein, Hellboy, Karl Ruprect Kroenen, Leopold Kurtz, Tom Manning, Grigori Rasputin, Torch of Liberty, Klaus Werner von Krupt |
| 10 | An African Myth About A Frog | text story | 1 | script: Mike Mignola; pencils: Mike Mignola; inks: Mike Mignola; colors: Mark Chiarello | |
| 11 | Chapter Two | illustration | 1 | pencils: Mike Mignola; inks: Mike Mignola | |
| 12 | Hellboy: Seed of Destruction #2 Cover | cover reprint (on interior page) | 1 | pencils: Mike Mignola, Arthur Adams; inks: Mike Mignola, Arthur Adams | Hellboy, Monkeyman, Ann O'Brien, Axwell Tiberius |
| 13 | Seed of Destruction Chapter Two | comic story | 24 | script: Mike Mignola, John Byrne; pencils: Mike Mignola; inks: Mike Mignola; colors: Mark Chiarello; letters: John Byrne, Mike Mignola | Langdon Everett Caul, Hellboy, Grigori Rasputin, Abe Sapien, Liz Sherman |
| 14 | Chapter Three | illustration | 1 | pencils: Mike Mignola; inks: Mike Mignola | |
| 15 | Hellboy: Seed of Destruction #3 Cover | cover reprint (on interior page) | 1 | pencils: Mike Mignola, Arthur Adams; inks: Mike Mignola, Arthur Adams | Hellboy, Monkeyman, Ann O'Brien, Axwell Tiberius |
| 16 | Seed of Destruction Chapter Three | comic story | 24 | script: Mike Mignola, John Byrne; pencils: Mike Mignola; inks: Mike Mignola; colors: Mark Chiarello; letters: John Byrne, Mike Mignola | Trevor Bruttenholm, Langdon Everett Caul, Ilsa Haupstein, Hellboy, Karl Ruprect Kroenen, Grigori Rasputin, Abe Sapien, Liz Sherman, Klaus Werner von Krupt |
| 17 | Chapter Four | illustration | 1 | pencils: Mike Mignola; inks: Mike Mignola | |
| 18 | Hellboy: Seed of Destruction #4 Cover | cover reprint (on interior page) | 1 | pencils: Mike Mignola, Arthur Adams; inks: Mike Mignola, Arthur Adams | Hellboy, Monkeyman, Ann O'Brien, Axwell Tiberius |
| 19 | Seed of Destruction Chapter Four | comic story | 23 | script: Mike Mignola, John Byrne; pencils: Mike Mignola; inks: Mike Mignola; colors: Mark Chiarello; letters: John Byrne, Mike Mignola | Langdon Everett Caul, Ilsa Haupstein, Hellboy, Karl Ruprect Kroenen, Grigori Rasputin, Abe Sapien, Liz Sherman, Klaus Werner von Krupt |
| 20 | Where the Hell Did He Come From? | foreword, introduction, preface, afterword | 2 | script: Mike Mignola; pencils: Mike Mignola; inks: Mike Mignola | Langdon Everett Caul, Hellboy, Abe Sapien, Liz Sherman |
| 21 | More First Things | foreword, introduction, preface, afterword | 1 | script: Mike Mignola; pencils: Mike Mignola; inks: Mike Mignola | Hellboy |
| 22 | Mike Mignola's Hellboy | comic story | 4 | script: Mike Mignola, John Byrne; pencils: Mike Mignola; inks: Mike Mignola; colors: Matthew Hollingsworth; letters: Mike Mignola, John Byrne | Hellboy |
| 23 | Mike Mignola's Hellboy | comic story | 4 | script: Mike Mignola, John Byrne; pencils: Mike Mignola; inks: Mike Mignola; colors: Matthew Hollingsworth; letters: Mike Mignola, John Byrne | Hellboy, Herman von Klempt First |
| 24 | Images of Hellboy | illustration | 1 | pencils: Art Adams; inks: Art Adams; colors: Matthew Hollingsworth | Hellboy |
| 25 | - | illustration | 1 | pencils: Simon Bisley; inks: Simon Bisley; colors: Matthew Hollingsworth | Hellboy |
| 26 | - | illustration | 1 | pencils: Mike Allred; inks: Mike Allred; colors: Mike Allred | Langdon Everett Caul, Hellboy, Madman, Abe Sapien |
| 27 | - | illustration | 1 | pencils: Art Adams; inks: Art Adams; colors: Matthew Hollingsworth | Hellboy |
| 28 | - | illustration | 1 | pencils: Frank Miller; inks: Frank Miller | Hellboy |
| 29 | - | illustration | 1 | pencils: Fred Blanchard; inks: Fred Blanchard; colors: Fred Blanchard | Hellboy |
| 30 | - | illustration | 1 | pencils: Gary Gianni; inks: Gary Gianni | Hellboy |
| 31 | Paperback Collection and Graphic Novels Avilable from Dark Horse | promo (ad from the publisher) | 1 | letters: typeset | |
| 32 | - | illustration | 1 | pencils: Mike Mignola; inks: Mike Mignola | |
| 33 | - | promo (ad from the publisher) | 1 | script: Robert Bloch; pencils: Mike Mignola; inks: Mike Mignola | Hellboy |