| 0 | - | cover | 1 | pencils: Jim Mooney, Curt Swan; inks: Sheldon Moldoff, George Klein; letters: Ira Schnapp | Supergirl; Jerro; Comet; Streaky; Legion of Super-Heroes [Cosmic Boy; Saturn Girl; Lightning Lad]; Superboy |
| 1 | - | table of contents | 1 | letters: typeset | |
| 2 | The Supergirl from Krypton! | comic story | 7.67 | script: Otto Binder; pencils: Al Plastino; inks: Al Plastino; letters: Joe Letterese; editing: Mort Weisinger | Superman [Kal-El; Clark Kent]; Supergirl [Kara Zor-El] (introduction, first appearance, origin); Zor-El (introduction); Miss Hart (introduction) |
| 3 | When Supergirl Met Jimmy Olsen | text article | 0.33 | script: E. Nelson Bridwell | |
| 4 | Second Smash Issue! | promo (ad from the publisher) | 0.5 | pencils: Murphy Anderson; inks: Murphy Anderson; letters: Ira Schnapp | |
| 5 | The Cave-Girl of Steel! | comic story | 7 | script: Otto Binder; pencils: Jim Mooney; inks: Jim Mooney | Supergirl [Linda Lee]; Miss Hart; Superman (cameo) |
| 6 | Supergirl's First Romance! | comic story | 10 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney | Supergirl; Jerro the Merboy (first appearance); Lori Lemaris; Ronal; Freddy Blake |
| 7 | Riddler on the Move | promo (ad from the publisher) | 0.5 | pencils: Gil Kane; inks: Murphy Anderson; letters: Ira Schnapp | |
| 8 | Supergirl's Super-Pet! | comic story | 8 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney; letters: Milt Snapinn | Supergirl [Linda Lee]; Streaky (first appearance); Miss Hart |
| 9 | Supergirl's Two Sets of Parents | text article | 1 | script: E. Nelson Bridwell; pencils: Jim Mooney; inks: Jim Mooney | |
| 10 | Supergirl's Fortress of Solitude! | comic story | 11 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney | Supergirl; Superman; Streaky; Professor Damon Brant (villain); Mrs. Brant (villain); Miss Hart |
| 11 | The Three Super-Heroes! | comic story | 11 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney; letters: Joe Letterese | Supergirl; Legion of Super-Heroes [Cosmic Boy; Lightning Lad; Saturn Girl; Chameleon Boy (introduction, cameo); Colossal Boy (introduction, cameo); Invisible Kid [Lyle Norg] (introduction, cameo)]; Superman (cameo) |
| 12 | Superboy Meets Supergirl! | comic story | 8 | script: Jerry Siegel; pencils: Curt Swan; inks: John Forte; letters: Joe Letterese | Superboy; Supergirl; Superman; Zor-El (flashback) |
| 13 | - | comic story | 1 | script: Jerry Siegel; pencils: Jim Mooney; inks: Jim Mooney | Superman; Supergirl |
| 14 | The Super-Steed of Steel! | comic story | 10.67 | script: Leo Dorfman; pencils: Jim Mooney; inks: Jim Mooney; letters: Milt Snapinn | Supergirl [Linda Danvers]; Comet the Super-Horse; Dick Malverne; Streaky the Super-Cat; Krypto (dream); Fred Danvers; Edna Danvers; Mace Greede |
| 15 | The Origin of Super-Horse | text article | 0.33 | script: E. Nelson Bridwell; pencils: Curt Swan | |
| 16 | Do You Make Life Hard for Yourself? | public service announcement | 1 | script: Jack Schiff; pencils: Bernard Baily; inks: Bernard Sachs; letters: Ira Schnapp | |