| 0 | - | cover | 1 | pencils: Glenn Barr; inks: Glenn Barr; colors: Glenn Barr | |
| 1 | The Big Book of Losers | credits, title page | 2 | pencils: Robbie Busch; inks: Robbie Busch | |
| 2 | Tabel of Contents | table of contents | 2 | letters: typeset | |
| 3 | Everyday Losers | foreword, introduction, preface, afterword | 1 | script: Paul Kirchner | |
| 4 | Adam | comic story | 1 | script: Paul Kirchner; pencils: Alex Wald; inks: Alex Wald | |
| 5 | Can't Win for Losing | comic story | 1 | script: Nancy A. Collins; pencils: Bruce Patterson; inks: Bruce Patterson | |
| 6 | Sore Losers | comic story | 2 | script: Nancy A. Collins; pencils: Bryan Talbot; inks: Bryan Talbot | |
| 7 | Wrong Place, Wrong Time! | comic story | 2 | script: Nancy A. Collins; pencils: Scott Shaw!; inks: Scott Shaw! | |
| 8 | Losers Weepers | comic story | 2 | script: Paul Kirchner; pencils: Robbie Busch; inks: Robbie Busch | |
| 9 | Get a Life | comic story | 2 | script: Nancy A. Collins; pencils: Tayyar Ozkan; inks: Tayyar Ozkan | |
| 10 | Sore Sports Losers | comic story | 4 | script: Paul Kirchner; pencils: Andrew Wendel; inks: Andrew Wendel | |
| 11 | The Golden Hill | comic story | 1 | script: Paul Kirchner; pencils: Shepherd Hendrix; inks: Shepherd Hendrix | |
| 12 | Yousouf Ishmaelo | comic story | 1 | script: Paul Kirchner; pencils: Steve Vance; inks: Steve Vance | |
| 13 | Pavel Navrotsky's Pig Pen | comic story | 2 | script: Paul Kirchner; pencils: Frank Quitely; inks: Frank Quitely | |
| 14 | Old Losers Never Die | comic story | 1 | script: Paul Kirchner; pencils: Bob Fingerman; inks: Bob Fingerman | |
| 15 | Loss Leaders | foreword, introduction, preface, afterword | 1 | script: Paul Kirchner | |
| 16 | Presidential Also-Rans | comic story | 3 | script: Paul Kirchner; pencils: Gordon Purcell; inks: Gordon Purcell | |
| 17 | Harold Stassen | comic story | 1 | script: Paul Kirchner; pencils: Shannon Wheeler; inks: Shannon Wheeler | |
| 18 | William Henry Harrison | comic story | 2 | script: Paul Kirchner; pencils: Gray Morrow; inks: Gray Morrow | |
| 19 | James Garfield: Martyr to Medicine | comic story | 2 | script: Paul Kirchner; pencils: Glenn Barr; inks: Glenn Barr | |
| 20 | Thomas Paine | comic story | 4 | script: Paul Kirchner; pencils: Jason Lutes; inks: Jason Lutes | |
| 21 | The Hunt Brothers | comic story | 2 | script: Nancy A. Collins; pencils: Peter Kuper; inks: Peter Kuper | |
| 22 | Leon Trotsky | comic story | 4 | script: Paul Kirchner; pencils: Tom Sutton; inks: Tom Sutton | |
| 23 | Rudolf Hess: Uberloser | comic story | 2 | script: Paul Kirchner; pencils: Ty Templeton; inks: Ty Templeton | |
| 24 | Yukio Mishima | comic story | 3 | script: Paul Kirchner; pencils: Joe Sacco; inks: Joe Sacco | |
| 25 | Lunchtime for Victor Biaka-Bod | comic story | 1 | script: Paul Kirchner; pencils: Russell Braun; inks: Russell Braun | |
| 26 | Croesus | comic story | 2 | script: Paul Kirchner; pencils: Marie Severin; inks: Marie Severin | |
| 27 | Montezuma | comic story | 5 | script: Paul Kirchner; pencils: Robin Smith; inks: Robin Smith | |
| 28 | Losing Propositions | foreword, introduction, preface, afterword | 1 | script: Paul Kirchner | |
| 29 | The Edsel | comic story | 2 | script: Nancy A. Collins; pencils: Lee Moder; inks: Lee Moder | |
| 30 | The Picturephone | comic story | 2 | script: Nancy A. Collins; pencils: Val Semeiks; inks: Val Semeiks | |
| 31 | New Coke | comic story | 4 | script: Nancy A. Collins; pencils: Randy DuBurke; inks: Randy DuBurke | |
| 32 | The Paper Dress | comic story | 2 | script: Paul Kirchner; pencils: Art Wetherell; inks: Art Wetherell | |
| 33 | Cars of Future Past | comic story | 3 | script: Nancy A. Collins; pencils: Rick Geary; inks: Rick Geary | |
| 34 | Women's Urinals | comic story | 1 | script: Nancy A. Collins; pencils: Kirk Tingblad; inks: Kirk Tingblad | |
| 35 | Movie Gimmicks Time Forgot | comic story | 2 | script: Nancy A. Collins; pencils: B. K. Taylor; inks: B. K. Taylor | |
| 36 | Smokeless Smokes | comic story | 2 | script: Nancy A. Collins; pencils: James Romberger; inks: James Romberger | |
| 37 | Susan B. Anthony's Dollar | comic story | 2 | script: Paul Kirchner; pencils: Gahan Wilson; inks: Gahan Wilson | |
| 38 | Fallout Shelters | comic story | 3 | script: Paul Kirchner; pencils: Marshall Rogers; inks: Marshall Rogers | |
| 39 | The Loser Sound | foreword, introduction, preface, afterword | 1 | script: Paul Kirchner | |
| 40 | Meet: Milli Vanilli | comic story | 2 | script: Irwin Chusid; pencils: Gregory Benton; inks: Gregory Benton | |
| 41 | Spade Cooley: King of Western Swing | comic story | 3 | script: Irwin Chusid; pencils: Richard Piers Rayner; inks: Richard Piers Rayner | |
| 42 | Frankie Lymon | comic story | 3 | script: Irwin Chusid; pencils: Karen Platt; inks: Karen Platt | |
| 43 | The Cherry Sisters | comic story | 4 | script: Irwin Chusid; pencils: Justin Green; inks: Justin Green | |
| 44 | From Moondog to Scapegoat | comic story | 2 | script: Irwin Chusid; pencils: Hilary Barta; inks: Hilary Barta | |
| 45 | Carrie: The Musical | comic story | 2 | script: Nancy A. Collins; pencils: Paul Guinan; inks: Paul Guinan | |
| 46 | Joe Meek's Musical Rocket Science | comic story | 5 | script: Irwin Chusid; pencils: D'Israeli D'Emon Draughtsman; inks: D'Israeli D'Emon Draughtsman | |
| 47 | Not a Moment to Lose | foreword, introduction, preface, afterword | 1 | script: Paul Kirchner | |
| 48 | The Crash of '29 | comic story | 2 | script: Nancy A. Collins; pencils: Dick Giordano; inks: Dick Giordano | |
| 49 | George Armstrong Custer | comic story | 5 | script: Paul Kirchner; pencils: Ralph Reese; inks: Ralph Reese | |
| 50 | Dead Letters: The First Airmail Flight | comic story | 1 | script: Paul Kirchner; pencils: George Evans; inks: George Evans | |
| 51 | The Dalton Gang's Last Raid | comic story | 4 | script: Paul Kirchner; pencils: Alan Weiss; inks: Alan Weiss | |
| 52 | The FBI Raid on Little Bohemia | comic story | 4 | script: Paul Kirchner; pencils: Carlos Ezquerra; inks: Carlos Ezquerra | |
| 53 | Technocracy: Better Living Through Technology | comic story | 2 | script: Nancy A. Collins; pencils: Jeff Nicholson; inks: Jeff Nicholson | |
| 54 | The Maginot Line | comic story | 2 | script: Paul Kirchner; pencils: Dan Burr; inks: Dan Burr | |
| 55 | Watergate | comic story | 4 | script: Paul Kirchner; pencils: Joe Staton; inks: Joe Staton | |
| 56 | Nicholas Leeson Loses His Barings | comic story | 3 | script: Paul Kirchner; pencils: Ted Slampyak; inks: Ted Slampyak | |
| 57 | The Science of Losing | foreword, introduction, preface, afterword | 1 | script: Paul Kirchner | |
| 58 | Patently Ridiculous | comic story | 2 | script: Nancy A. Collins; pencils: Steven Lieber; inks: Steven Lieber | |
| 59 | Edwin Armstrong: Father of FM Radio | comic story | 3 | script: Paul Kirchner; pencils: Tom Palmer; inks: Tom Palmer | |
| 60 | Edison's Cement Housing | comic story | 1 | script: Paul Kirchner; pencils: Tom Morgan; inks: Tom Morgan | |
| 61 | Nicholas Cugnot | comic story | 2 | script: Paul Kirchner; pencils: Paul Gulacy; inks: Paul Gulacy | |
| 62 | Dr. James Graham | comic story | 2 | script: Paul Kirchner; pencils: Will Simpson; inks: Will Simpson | |
| 63 | The Pneumatic Subway | comic story | 2 | script: Nancy A. Collins; pencils: Steve Leialoha; inks: Steve Leialoha | |
| 64 | Mark Twain: Investor | comic story | 2 | script: Paul Kirchner; pencils: Joe Orlando; inks: Joe Orlando | |
| 65 | Howard Hughes and the Spruce Goose | comic story | 4 | script: Paul Kirchner; pencils: Graham Higgins; inks: Graham Higgins | |
| 66 | Elisha Gray: The Real Inventor of the Telephone! | comic story | 3 | script: Nancy A. Collins; pencils: Bill Alger; inks: Bill Alger | |
| 67 | Doomed Adventurers | foreword, introduction, preface, afterword | 1 | script: Paul Kirchner | |
| 68 | Ulrich Von Lichtenstein: What a Knight! | comic story | 5 | script: Paul Kirchner; pencils: Hunt Emerson; inks: Hunt Emerson | |
| 69 | Fletcher Christian and the Bounty Mutineers | comic story | 3 | script: Paul Kirchner; pencils: George Freeman; inks: George Freeman | |
| 70 | Thomas Nuttall: Lost Explorer | comic story | 1 | script: Paul Kirchner; pencils: Rafael Kayanan; inks: Rafael Kayanan | |
| 71 | Captain Fonck | comic story | 2 | script: Nancy A. Collins; pencils: Charles Adlard; inks: Charles Adlard | |
| 72 | Clem Sohn | comic story | 2 | script: Paul Kirchner; pencils: Kieron Dwyer; inks: Kieron Dwyer | |
| 73 | Tom Gurr, Salvage King | comic story | 2 | script: Paul Kirchner; pencils: Ward Sutton; inks: Ward Sutton | |
| 74 | Richard Haselton | comic story | 3 | script: Paul Kirchner; pencils: Graham Manley; inks: Graham Manley | |
| 75 | Sors Hariezon | comic story | 1 | script: Paul Kirchner; pencils: Eric Shanower; inks: Eric Shanower | |
| 76 | Daniel K. Ludwig | comic story | 2 | script: Paul Kirchner; pencils: John Estes; inks: John Estes | |
| 77 | Bob Ford | comic story | 2 | script: Paul Kirchner; pencils: Mark A. Nelson; inks: Mark A. Nelson | |
| 78 | The Gatti Gang: Italy's Least Wanted | comic story | 2 | script: Paul Kirchner; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 79 | Francis Gary Powers | comic story | 2 | script: Paul Kirchner; pencils: Ed Hannigan; inks: Ed Hannigan | |
| 80 | Anna Edson Taylor | comic story | 2 | script: Paul Kirchner; pencils: Rick Parker; inks: Rick Parker | |
| 81 | Captain Kidd | comic story | 5 | script: Paul Kirchner; pencils: Roger Langridge; inks: Roger Langridge | |
| 82 | Copyright Information | text article | 1 | letters: typeset | |
| 83 | Biographies | text article | 2 | letters: typeset | |
| 84 | Bibliography | text article | 2 | letters: typeset | |