| 0 | - | cover | 1 | pencils: Steve Vance; inks: Steve Vance; colors: Steve Vance | |
| 1 | The Big Book of Vice | credits, title page | 1 | pencils: Alan Kupperberg; inks: Alan Kupperberg | |
| 2 | Table of Contents | table of contents | 2 | letters: typeset | |
| 3 | Sin Cities | foreword, introduction, preface, afterword | 1 | script: Steve Vance | |
| 4 | Village of the Damned | comic story | 1 | script: Dave Stern; pencils: Ivan Brunetti; inks: Ivan Brunetti | |
| 5 | Phenix City | comic story | 3 | script: Steve Vance; pencils: Bob Fingerman; inks: Bob Fingerman | |
| 6 | Fantasy Island | comic story | 4 | script: Dave Stern; pencils: Rick Geary; inks: Rick Geary | |
| 7 | Las Vegas | comic story | 5 | script: Steve Vance; pencils: Deryl Skelton; inks: Deryl Skelton | |
| 8 | The Deuce | comic story | 3 | script: Dave Stern; pencils: Alan Kupperberg; inks: Alan Kupperberg | |
| 9 | Rated XXX | comic story | 1 | script: Dave Stern; pencils: Alwyn Talbot; inks: Alwyn Talbot | |
| 10 | Alcohol | foreword, introduction, preface, afterword | 1 | script: Steve Vance | |
| 11 | The First Drug | comic story | 2 | script: Steve Vance; pencils: Dan Spiegle; inks: Dan Spiegle | |
| 12 | The Battle of the Booze | comic story | 4 | script: Steve Vance; pencils: Tom Sutton; inks: Tom Sutton | |
| 13 | Carry Nation | comic story | 3 | script: Steve Vance; pencils: Lennie Mace; inks: Lennie Mace | |
| 14 | The Noble Disaster | comic story | 4 | script: Steve Vance; pencils: Hilary Barta; inks: Hilary Barta | |
| 15 | Izzy & Moe | comic story | 2 | script: Steve Vance; pencils: Armando Gil; inks: Armando Gil | |
| 16 | White Lightning | comic story | 1 | script: Steve Vance; pencils: Hunt Emerson; inks: Hunt Emerson | |
| 17 | What's in All Those Bottles? | comic story | 2 | script: Steve Vance; pencils: Joe Staton; inks: Joe Staton | |
| 18 | Friends of Bill W. | comic story | 2 | script: Steve Vance; pencils: Dan Burr; inks: Dan Burr | |
| 19 | So You Want to Know About Alcohol? | comic story | 1 | script: Steve Vance; pencils: Steve Vance; inks: Steve Vance | |
| 20 | Drugs | foreword, introduction, preface, afterword | 1 | script: Steve Vance | |
| 21 | The Stoned Age | comic story | 1 | script: Steve Vance; pencils: Marshall Rogers; inks: Marshall Rogers | |
| 22 | Cocaine: The Curse of the Incas | comic story | 5 | script: Steve Vance; pencils: Galen Showman; inks: Galen Showman | |
| 23 | The Poppy's Strange Fruit | comic story | 5 | script: Steve Vance; pencils: Gregory Benton; inks: Gregory Benton | |
| 24 | The Opium Wars | comic story | 3 | script: Steve Vance; pencils: Alec Stevens; inks: Alec Stevens | |
| 25 | The Age of Absinthe | comic story | 2 | script: Steve Vance; pencils: Kieron Dwyer; inks: Kieron Dwyer | |
| 26 | Hemp Through History | comic story | 1 | script: Steve Vance; pencils: Ovidiu Nedelcu; inks: Ovidiu Nedelcu | |
| 27 | Reefer Madness | comic story | 3 | script: Steve Vance; pencils: Salgood Sam; inks: Salgood Sam | |
| 28 | Peyote, Sacred Cactus of the Southwest | comic story | 2 | script: Steve Vance; pencils: John Estes; inks: John Estes | |
| 29 | Albert Hoffman | comic story | 1 | script: Steve Vance; pencils: James Romberger; inks: James Romberger | |
| 30 | Timothy Leary, Psychedelic Guru | comic story | 3 | script: Steve Vance; pencils: James Romberger; inks: James Romberger | |
| 31 | America's Hidden Plague | comic story | 2 | script: Steve Vance; pencils: Glenn Barr; inks: Glenn Barr | |
| 32 | Caffeine Fiends | comic story | 1 | script: Steve Vance; pencils: Bahadir Boysal; inks: Bahadir Boysal | |
| 33 | Vice Styles of the Rich & Famous | comic story | 2 | script: Steve Vance; pencils: John Cebollero; inks: John Cebollero | |
| 34 | Tobacco | foreword, introduction, preface, afterword | 1 | script: Steve Vance | |
| 35 | The Roots of Tobacco | comic story | 2 | script: Steve Vance; pencils: Donald David; inks: Donald David | |
| 36 | Seeds of a Nation | comic story | 3 | script: Steve Vance; pencils: Steve Mannion; inks: Steve Mannion | |
| 37 | Buck Duke Cigarette King | comic story | 4 | script: Steve Vance; pencils: Charles Adlard; inks: Charles Adlard | |
| 38 | Gunsmoke | comic story | 1 | script: Steve Vance; pencils: Russ Heath; inks: Russ Heath | |
| 39 | Lucy Gaston vs. the Coffin Nail | comic story | 2 | script: Steve Vance; pencils: Ted Slampyak; inks: Ted Slampyak | |
| 40 | Smoke and Mirrors | comic story | 4 | script: Steve Vance; pencils: Terry LaBan; inks: Terry LaBan | |
| 41 | Warning! Cigarette Companies May Be Hazardous to Your Health | comic story | 4 | script: Steve Vance; pencils: Rina Piccolo; inks: Rina Piccolo | |
| 42 | Marlboro World | comic story | 1 | script: Steve Vance; pencils: Gray Morrow; inks: Gray Morrow | |
| 43 | Sex and More Sex | foreword, introduction, preface, afterword | 1 | script: Steve Vance | |
| 44 | Prostitutes of the Gods | comic story | 1 | script: Steve Vance; pencils: Rina Piccolo; inks: Rina Piccolo | |
| 45 | The Golden Age of Prostitution | comic story | 2 | script: Steve Vance; pencils: Jennifer Graves; inks: Jennifer Graves | |
| 46 | Harlots and Holy Men | comic story | 1 | script: Steve Vance; pencils: Joe Staton; inks: Joe Staton | |
| 47 | Mystery John | comic story | 1 | script: Steve Vance; pencils: B. K. Taylor; inks: B. K. Taylor | |
| 48 | The Whores of War | comic story | 2 | script: Steve Vance; pencils: Sam Glanzman; inks: Sam Glanzman | |
| 49 | The Victorians' Secret | comic story | 3 | script: Steve Vance; pencils: Michael Collins; inks: Michael Collins | |
| 50 | Hollywood Madams | comic story | 2 | script: Steve Vance; pencils: Steve Smith; inks: Steve Smith | |
| 51 | The Happy Hooker | comic story | 1 | script: Dave Stern; pencils: Glen Hanson; inks: Glen Hanson | |
| 52 | Mustang Ranch | comic story | 2 | script: Steve Vance; pencils: Alan Kupperberg; inks: Alan Kupperberg | |
| 53 | Sex Slaves | comic story | 3 | script: Steve Vance; pencils: Colleen Doran; inks: Colleen Doran | |
| 54 | The Pimp | comic story | 2 | script: Steve Vance; pencils: Denys Cowan; inks: Denys Cowan | |
| 55 | Mayflower Madam | comic story | 1 | script: Steve Vance; pencils: Christian Alamy; inks: Christian Alamy | |
| 56 | The Evolution of Porn | comic story | 3 | script: Steve Vance; pencils: Wm. Marshall Rogers; inks: Wm. Marshall Rogers | |
| 57 | Anthony Comstock | comic story | 3 | script: Steve Vance; pencils: Karl Heitmueller Jr.; inks: Karl Heitmueller Jr. | |
| 58 | Live Nude Girls | comic story | 1 | script: Steve Vance; pencils: David Monahan; inks: David Monahan | |
| 59 | Master of the Pornoverse | comic story | 3 | script: Steve Vance; pencils: John Cebollero; inks: John Cebollero | |
| 60 | King of Porn | comic story | 3 | script: Dave Stern; pencils: Bob Fingerman; inks: Bob Fingerman | |
| 61 | Sexual Revolutionary | comic story | 2 | script: Dave Stern; pencils: Russ Heath; inks: Russ Heath | |
| 62 | Patriot of Porn | comic story | 2 | script: Dave Stern; pencils: Mark Poutenis; inks: Mark Poutenis | |
| 63 | The Sultan of Sleaze | comic story | 2 | script: Dave Stern; pencils: Danny Hellman; inks: Danny Hellman | |
| 64 | Aphrodisiacs | comic story | 1 | script: Steve Vance; pencils: Floyd Hughes; inks: Floyd Hughes | |
| 65 | Gambling | foreword, introduction, preface, afterword | 1 | script: Steve Vance | |
| 66 | Basic Instinct | comic story | 3 | script: Dave Stern; pencils: Stephen Sadowski; inks: Stephen Sadowski | |
| 67 | The Devil's Invention | comic story | 4 | script: Dave Stern; pencils: Randy DuBurke; inks: Randy DuBurke | |
| 68 | The Winning Ticket | comic story | 4 | script: Dave Stern; pencils: Tayyar Ozkan; inks: Tayyar Ozkan | |
| 69 | Tumblin' Vice | comic story | 2 | script: Dave Stern; pencils: Michael Collins; inks: Michael Collins | |
| 70 | The Godfather of Gambling | comic story | 2 | script: Dave Stern; pencils: Brad Teare; inks: Brad Teare | |
| 71 | History-Making Bets | comic story | 2 | script: Dave Stern; pencils: Gordon Purcell; inks: Gordon Purcell | |
| 72 | The Anti-Gamblers | comic story | 5 | script: Dave Stern; pencils: Vincent Deporter; inks: Vincent Deporter | |
| 73 | Bright Lights, Big Bucks | comic story | 4 | script: Dave Stern; pencils: Robert Snyder; inks: Robert Snyder | |
| 74 | The Dream Factory | comic story | 2 | script: Dave Stern; pencils: Stephen DeStefano; inks: Stephen DeStefano | |
| 75 | The New Buffalo | comic story | 2 | script: Dave Stern; pencils: Salgood Sam; inks: Salgood Sam | |
| 76 | Virtual Vegas | comic story | 1 | script: Dave Stern; pencils: John Heebink; inks: John Heebink | |
| 77 | The Devil's Playground | foreword, introduction, preface, afterword | 1 | script: Steve Vance | |
| 78 | Breeding Grounds of Vice | comic story | 5 | script: Steve Vance; pencils: Roger Langridge; inks: Roger Langridge | |
| 79 | Comic Books - Threat or Menace? | comic story | 5 | script: Steve Vance; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 80 | Pick a Card | comic story | 2 | script: Steve Vance; pencils: Hunt Emerson; inks: Hunt Emerson | |
| 81 | Sweet Tooth | comic story | 1 | script: Steve Vance; pencils: Nick Bertozzi; inks: Nick Bertozzi | |
| 82 | Copyright Information | text article | 1 | letters: typeset | |
| 83 | Biographies | text article | 2 | letters: typeset | |
| 84 | Bibliography | text article | 2 | letters: typeset | |