| 0 | - | cover | 2 | pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Sherilyn Van Valkenburgh | |
| 1 | Introduction by Grant Morrison | foreword, introduction, preface, afterword | 5 | script: Grant Morrison; pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Sherilyn Van Valkenburgh | |
| 2 | Blank Page | blank page(s) | 1 | | |
| 3 | Enigma | credits, title page | 2 | pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Sherilyn Van Valkenburgh | |
| 4 | The Lizard The Head The Enigma | cover reprint (on interior page) | 1 | pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Duncan Fegredo | Enigma |
| 5 | Episode 1: The Lizard, The Head, The Enigma | comic story | 24 | script: Peter Milligan; pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Sherilyn Van Valkenburgh; letters: John Costanza | Michael Smith (first appearance); Enigma (first appearance); Sandra (first appearance); Victor Lamont (first appearance); Frank (first appearance); Bob (first appearance, death); Joe (first appearance); The Head [Roger Cliff] (first appearance, villain) |
| 6 | The Truth | cover reprint (on interior page) | 1 | pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Duncan Fegredo | Enigma; The Truth [Victor Lamont] |
| 7 | Episode 2: The Truth | comic story | 24 | script: Peter Milligan; pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Sherilyn Van Valkenburgh; letters: John Costanza | Enigma; Michael Smith; Sandra; Craig (first appearance); Mulligan (first appearance); The Truth [Victor Lamont] (villain); The Head [Roger Cliff] (villain, death) |
| 8 | The Good Boy | cover reprint (on interior page) | 1 | pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Duncan Fegredo | Enigma; Envelope Girl [Victoria Yes] |
| 9 | Episode 3: The Good Boy | comic story | 24 | script: Peter Milligan; pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Sherilyn Van Valkenburgh; letters: John Costanza | Enigma; Michael Smith; Titus Bird (first appearance); Sandra; Mrs. Smith (flashback); Joe; Saturn (first appearance); William Williams (first appearance); Envelope Girl [Victoria Yes] (first appearance, villain); The Truth [Victor Lamont] (villain) |
| 10 | "...And Then What?" | cover reprint (on interior page) | 1 | pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Duncan Fegredo | Enigma |
| 11 | Episode 4: And Then What? | comic story | 24 | script: Peter Milligan; pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Sherilyn Van Valkenburgh; letters: John Costanza | Enigma; Michael Smith; Titus Bird; Sandra; John Cade (first appearance, death); The Enigmatics; Envelope Girl [Victoria Yes] (villain); The Truth [Victor Lamont] (villain) |
| 12 | Lizards and Ghosts | cover reprint (on interior page) | 1 | pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Duncan Fegredo | Enigma; The Interior League |
| 13 | Episode 5: Lizards and Ghosts | comic story | 24 | script: Peter Milligan; pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Sherilyn Van Valkenburgh; letters: John Costanza | Enigma; Michael Smith; Titus Bird; The Enigmatics; The Interior League (first appearance, villains); Envelope Girl [Victoria Yes] (villain) |
| 14 | The End of the World | cover reprint (on interior page) | 1 | pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Duncan Fegredo | Enigma |
| 15 | Episode 6: The End of the World | comic story | 24 | script: Peter Milligan; pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Sherilyn Van Valkenburgh; letters: John Costanza | Enigma; Michael Smith; Titus Bird; Stephen (first appearance, flashback); Envelope Girl [Victoria Yes] (villain) |
| 16 | Sex in Arizona | cover reprint (on interior page) | 1 | pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Duncan Fegredo | Enigma; Michael Smith |
| 17 | Episode 7: Sex in Arizona | comic story | 24 | script: Peter Milligan; pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Sherilyn Van Valkenburgh; letters: John Costanza | Enigma; Michael Smith; Titus Bird; Mrs. Smith (flashback); Victoria Yes [also as Enigma's mother] (villain) |
| 18 | Queer | cover reprint (on interior page) | 1 | pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Duncan Fegredo | Enigma; Michael Smith |
| 19 | Episode 8: Queer | comic story | 24 | script: Peter Milligan; pencils: Duncan Fegredo; inks: Duncan Fegredo; colors: Sherilyn Van Valkenburgh; letters: John Costanza | Enigma (origin); Michael Smith; Titus Bird; Doug Moon (first appearance, flashback); Enigma's mother |
| 20 | Also available from Vertigo | promo (ad from the publisher) | 1 | letters: typeset | |
| 21 | Blank Page | blank page(s) | 1 | | |