| 0 | - | cover | 1 | pencils: Alex Ross; inks: Alex Ross; colors: Alex Ross | Samaritan |
| 1 | - | illustration | 1 | | |
| 2 | Kurt Busiek's Astro City: Life in the Big City | credits, title page | 2 | pencils: Art Nichols; inks: Art Nichols | |
| 3 | - | credits, title page | 1 | letters: typeset | |
| 4 | - | foreword, introduction, preface, afterword | 1 | script: Kurt Busiek, Brent E. Anderson, Alex Ross; pencils: Alex Ross; inks: Alex Ross; colors: Alex Ross | Samaritan |
| 5 | Introduction | foreword, introduction, preface, afterword | 5 | script: Kurt Busiek; pencils: Brent E. Anderson; inks: Brent E. Anderson | Samaritan; Honor Guard [The Black Napier; MPH; The N-Forcer; Cleopatra; Quarrel [Jessica Darlene Taggart]]; Jack-in-the-Box |
| 6 | Chapter 1 | credits, title page | 1 | letters: typeset | |
| 7 | - | illustration | 1 | pencils: Curt Swan; inks: Murphy Anderson | Samaritan |
| 8 | In Dreams | comic story | 24 | script: Kurt Busiek; pencils: Brent E. Anderson; inks: Brent E. Anderson; colors: Steve Buccellato, Electric Crayon; letters: Richard Starkings, John Gaushell | Samaritan [Asa Martin]; Rich; Karen; Shakira; Dr. Saturday; Honor Guard [MPH; The Black Rapier; Cleopatra; Quarrel [Jessica Darlene Taggart]; N-Forcer; Beautie]; The Menagerie Gang [Foxy Loxy]; Ms. Cavendish; The Living Nightmare |
| 9 | Chapter 2 | credits, title page | 1 | letters: typeset | |
| 10 | - | illustration | 1 | pencils: George Tuska; inks: Joe Sinnott | The Silver Agent |
| 11 | The Scoop | comic story | 24 | script: Kurt Busiek; pencils: Brent E. Anderson; inks: Brent E. Anderson; colors: Steve Buccellato, Electric Crayon; letters: Richard Starkings, John Gaushell | Eliot Mills; The Silver Agent; Jack Meskin; Karnus; Shirak the Devourer; The Honor Guard [Max O'Millions; Cleopatra; Leopardman; Kitkat; Starwoman; The N-Forcer; The Bouncing Beatnik]; The Old Soldier |
| 12 | Chapter 3 | credits, title page | 1 | letters: typeset | |
| 13 | - | illustration | 1 | pencils: Jim Mooney; inks: Jim Mooney | Jack-in-the-Box |
| 14 | A Little Knowledge | comic story | 24 | script: Kurt Busiek; pencils: Brent E. Anderson; inks: Brent E. Anderson; colors: Steve Buccellato, Electric Crayon; letters: Richard Starkings, John Gaushell | Jack-in-the-Box [Zachary Johnson]; Andrew Eisenstein; Tamra Dixon; The Deacon; Quarrel [Jessica Darlene Taggart] |
| 15 | Chapter 4 | credits, title page | 1 | letters: typeset | |
| 16 | - | illustration | 1 | pencils: John Romita; inks: John Romita | Winged Victory |
| 17 | Safeguards | comic story | 24 | script: Kurt Busiek; pencils: Brent E. Anderson; inks: Brent E. Anderson; colors: Steve Buccellato, Electric Crayon; letters: Richard Starkings, John Gaushell | Marta; The Hanged Man; Mr. Irons; Winged Victory; Darcy Conroy; Shellie; Jenny; Mama (Marta's mother); Nicu (Marta's father); First Family [Nick Furst; Natalie Furst; Julius Furst; Augustus Furst; Rex]; Unholy Alliance [Demolitia; Flamethrower; Glowworm; Spice; Slamburger] |
| 18 | Chapter 5 | credits, title page | 1 | letters: typeset | |
| 19 | - | illustration | 1 | pencils: Jim Mooney; inks: Jim Mooney | Jack-in-the-Box |
| 20 | Reconnaissance | comic story | 24 | script: Kurt Busiek; pencils: Brent E. Anderson; inks: Brent E. Anderson; colors: Steve Buccellato, Electric Crayon; letters: Richard Starkings, John Gaushell | Mr. Bridwell; Astro City Irregulars [El Robo; Palmetto; Ruby; Juice; Homegirl; Stray]; Crackerjack [Eugene Wallace]; Samaritan; Starwoman; Gnomicron; Quarrel [Jessica Darlene Taggart]; Steel Devil; Jack-in-the-Box; Nightingale; Sunbird |
| 21 | Chapter 6 | credits, title page | 1 | letters: typeset | |
| 22 | - | illustration | 1 | pencils: Curt Swan; inks: Murphy Anderson | Samaritan |
| 23 | Dinner at Eight | comic story | 24 | script: Kurt Busiek; pencils: Brent E. Anderson; inks: Brent E. Anderson; colors: Steve Buccellato, Electric Crayon; letters: Richard Starkings, John Gaushell | Samaritan; Winged Victory; N-Forcer; Quarrel [Jessica Darlene Taggart]; Cleopatra; The Black Napier; MPH; Beautie; Crackerjack; Goldenboy; First Family [Rex; Nick Furst; Natalie Furst; Astra Furst; Julius Furst; Augustus Furst] |
| 24 | Infrastructure | credits, title page | 1 | letters: typeset | |
| 25 | City Planning | text article | 2 | script: Kurt Busiek; pencils: Brent E. Anderson, Kurt Busiek; letters: Brent E. Anderson, Kurt Busiek | |
| 26 | Samaritan | text article | 2 | script: Kurt Busiek; pencils: Alex Ross | Samaritan |
| 27 | Honor Guard | text article | 3.25 | script: Kurt Busiek; pencils: Alex Ross, Brent E. Anderson, Kurt Busiek; letters: Alex Ross | Honor Guard [Cleopatra; The Silver Agent; N-Forcer; Quarrel [Jessica Darlene Taggart]; Starwoman; Beautie; MPH] |
| 28 | Jack-in-the-Box | text article | 0.75 | script: Kurt Busiek; pencils: Alex Ross; letters: Alex Ross | Jack-in-the-Box |
| 29 | Shark Men | text article | 1 | script: Kurt Busiek; pencils: Alex Ross; letters: Alex Ross | |
| 30 | First Family | text article | 1 | script: Kurt Busiek; pencils: Alex Ross | Rex |
| 31 | Ordinary People | text article | 1 | script: Kurt Busiek; pencils: Alex Ross; letters: Alex Ross | Asa Martin [Samaritan]; Eliot Mills; Marta |
| 32 | Cover Gallery | credits, title page | 1 | letters: typeset | |
| 33 | - | illustration | 1 | pencils: Alex Ross | Samaritan |
| 34 | - | cover reprint (on interior page) | 1 | pencils: Alex Ross; inks: Alex Ross; colors: Alex Ross | Samaritan |
| 35 | - | illustration | 1 | pencils: Alex Ross | The Silver Agent |
| 36 | - | cover reprint (on interior page) | 1 | pencils: Alex Ross; inks: Alex Ross; colors: Alex Ross | The Silver Agent; Eliot Mills |
| 37 | - | illustration | 1 | pencils: Alex Ross | Jack-in-the-Box |
| 38 | - | cover reprint (on interior page) | 1 | pencils: Alex Ross; inks: Alex Ross; colors: Alex Ross | Jack-in-the-Box |
| 39 | - | illustration | 1 | pencils: Alex Ross | First Family [Nick Furst; Natalie Furst; Julius Furst; Augustus Furst; Rex; Astra Furst] |
| 40 | - | cover reprint (on interior page) | 1 | pencils: Alex Ross; inks: Alex Ross; colors: Alex Ross | Winged Victory; Marta |
| 41 | - | illustration | 1 | pencils: Alex Ross | Crackerjack |
| 42 | - | cover reprint (on interior page) | 1 | pencils: Alex Ross; inks: Alex Ross; colors: Alex Ross | Crackerjack |
| 43 | - | illustration | 1 | pencils: Alex Ross | Winged Victory |
| 44 | - | cover reprint (on interior page) | 1 | pencils: Alex Ross; inks: Alex Ross; colors: Alex Ross | Samaritan; Winged Victory |
| 45 | Acknowledgements | text article | 1 | script: Kurt Busiek, Brent E. Anderson, Alex Ross; pencils: Art Nichols; inks: Art Nichols | |