| 0 | Do You Dare Enter... the House of Mystery | cover | 1 | pencils: Nick Cardy; inks: Nick Cardy; colors: Sol Harrison | |
| 1 | The House of Mystery | table of contents | 1 | script: Joe Orlando; pencils: Sergio Aragonés; inks: Sergio Aragonés | Cain; Dracula |
| 2 | The House of Gargoyles! | comic story | 11.67 | script: Sergio Aragonés; pencils: Jack Sparling; inks: Jack Sparling; letters: Milt Snapinn | Cain (host); Francois (sculptor, flashback); French sculptor; Jimmy; Samuel |
| 3 | - | cartoon | 0.33 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; letters: Gaspar Saladino | |
| 4 | Lucky Wheel | activity | 1 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 5 | - | cartoon | 1 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 6 | The Secret of the Egyptian Cat | comic story | 10 | script: Robert Kanigher; pencils: Bernie Wrightson; inks: Bernie Wrightson; letters: Irv Watanabe | Cain (host); Isha (priestess); Konassos (sorcerer); Ra-Na (cat) |
| 7 | - | cartoon | 1 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 8 | The Widow's Walk | comic story | 10 | script: Howard Post; pencils: Neal Adams; inks: Joe Orlando; letters: Ben Oda | Angus Beame; Mary Bourne; Mr. Bourne (Mary's father); Homer Clyde (Mr. Bourne's servant); Mildred Clyde (Homer's wife); lawyer; various crewmen of Angus Beame; exotic item merchant; modern-day beachgoers |
| 9 | Roll the Lucky Dice! | activity | 1 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; letters: Gaspar Saladino | |
| 10 | House of Mystery | activity | 2 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | Cain; Gregory (gargoyle); Sergio Aragonés |
| 11 | - | activity | 1 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 12 | Mysteriously Yours - Cain and Gregory | illustration | 2 | pencils: Bernie Wrightson; inks: Bernie Wrightson | Cain; Gregory (gargoyle) |
| 13 | "His Name Is... Kane" | comic story | 6.5 | script: Mike Friedrich; pencils: Gil Kane; inks: Wally Wood; letters: Ben Oda | Abel; Carmine Infantino; Gil Kane; Joe Orlando |
| 14 | - | cartoon | 0.5 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 15 | - | cartoon | 1 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; letters: Sergio Aragonés | |
| 16 | The Devil's Doorway | comic story | 11 | script: Jack Oleck; pencils: Alex Toth; inks: Alex Toth; letters: John Costanza | Belial [Satan]; Beth Warren; Cain; Cathy Warren; Phillip Warren |
| 17 | - | cartoon | 1 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 18 | The Poster Plague! | comic story | 7 | script: Steve Skeates; pencils: Sergio Aragonés; inks: Sergio Aragonés; letters: Joe Letterese | Cain (host); Debbie; Gregory (gargoyle); Harold (cat); Warren |
| 19 | Nightmare | comic story | 12 | script: Robert Kanigher; pencils: Neal Adams, Joe Orlando; inks: Neal Adams, Joe Orlando; letters: John Costanza | Cain (host); Judy; Judy's father; Miss Winter (governess); Pan |
| 20 | Behind the Scenes at the House of Mystery | text article | 1 | script: Joe Orlando; pencils: Joe Orlando; inks: Joe Orlando | Alex Toth; Bernie Wrightson; Bob Haney; Cain the Caretaker; Gil Kane; Howie Post; Jack Oleck; Jack Sparling; Joe Orlando; Mike Friedrich; Neal Adams; Robert Kanigher; Sergio Aragones; Steve Skeates |
| 21 | Cain and His Gargoyle | activity | 1 | pencils: Sergio Aragonés; inks: Sergio Aragonés | Cain; Gregory (gargoyle) |