| 0 | - | cover | 0 | pencils: Gary Frank; inks: Gary Frank; colors: Brad Anderson | Superman; Lois Lane |
| 1 | - | cover | 1 | | |
| 2 | - | illustration | 2 | pencils: Joe Shuster; inks: Joe Shuster | |
| 3 | - | blank page(s) | 1 | | |
| 4 | Lois Lane: A Celebration of 75 Years | credits, title page | 1 | pencils: Joe Shuster; inks: Joe Shuster | |
| 5 | Editorial Credits | credits, title page | 1 | letters: typeset | |
| 6 | Table of Contents | table of contents | 3 | letters: typeset | |
| 7 | Part I - 1938-1956: Girl Reporter | foreword, introduction, preface, afterword | 2 | letters: typeset | |
| 8 | - | cover reprint (on interior page) | 1 | pencils: Joe Shuster; inks: Joe Shuster; colors: Jack Adler | |
| 9 | Superman Origin | comic story | 1 | script: Jerry Siegel; pencils: Joe Shuster; inks: Joe Shuster; colors: Strauss Engraving Company; letters: Joe Shuster | |
| 10 | The Coming of Superman | comic story | 11.67 | script: Jerry Siegel; pencils: Joe Shuster; inks: Joe Shuster; colors: Strauss Engraving Company; letters: Joe Shuster | Governor; Governor's butler |
| 11 | - | promo (ad from the publisher) | 0.33 | pencils: Joe Shuster; inks: Joe Shuster; colors: Strauss Engraving Company | |
| 12 | Revolution in San Monte | comic story | 12.67 | script: Jerry Siegel; pencils: Joe Shuster; inks: Joe Shuster | Superman [Clark Kent]; Lois Lane; Lola Cortez; George Taylor (cameo); Alex Greer (villain); Emil Norvell (villain) |
| 13 | Superman's Phony Manager | comic story | 12.67 | script: Jerry Siegel; pencils: Joe Shuster; inks: Joe Shuster; letters: Paul Lauretta | Superman [Clark Kent]; Jimmy Olsen (introduction, as an office boy); Nick Williams (villain, introduction); Lois Lane; George Taylor (unnamed) |
| 14 | Muscle-Training | activity | 0.33 | script: Jerry Siegel; pencils: Joe Shuster; inks: Joe Shuster; letters: Paul Lauretta | |
| 15 | The Bakery Counterfeiters | comic story | 4 | script: Don Cameron; pencils: Sam Citron; inks: Don Komisarow | Lois Lane; Superman [Clark Kent]; Perry White; Steve Bard (introduction); Noonan (Policeman); Carmody (Policeman); Fingers Gordon (villain, introduction); Pinball Miggsy (villain, introduction); Mr. Gratz (villain, introduction); Trigger (villain) |
| 16 | The Purloined Piggy Bank | comic story | 4 | script: Whitney Ellsworth; pencils: Sam Citron; inks: Don Komisarow | Clark Kent; Lois Lane; Mrs. Googenslocker; Willie Googenslocker; Handsome Harry Lars (villain, introduction); Gus (villain); Jo-Jo (villain) |
| 17 | The Foiled Frame-Up! | comic story | 4 | script: Whitney Ellsworth; pencils: Pete Riss; inks: Stan Kaye | Lois Lane; Clark Kent; Perry White; Mr. Marvin (villain, real estate broker); Moke Henders (villain, introduction) |
| 18 | Lois Lane Loves Clark Kent! | comic story | 8 | pencils: Wayne Boring; inks: Stan Kaye | Superman [Clark Kent]; Lois Lane; Perry White |
| 19 | Part II - 1957-1985: Superman's Girl Friend | foreword, introduction, preface, afterword | 2 | letters: typeset | |
| 20 | The Girl in Superman's Past | comic story | 8 | script: Jerry Coleman; pencils: Al Plastino; inks: Al Plastino | Lois Lane; Lana Lang; Superman [Clark Kent] |
| 21 | The New Lois Lane | comic story | 8 | script: Otto Binder; pencils: Ruben Moreira; inks: Al Plastino | "Con" Conners |
| 22 | The Fattest Girl in Metropolis! | cover reprint (on interior page) | 1 | pencils: Curt Swan; inks: Stan Kaye; letters: Ira Schnapp | |
| 23 | The Fattest Girl in Metropolis | comic story | 7.67 | script: Otto Binder; pencils: Kurt Schaffenberger; inks: Kurt Schaffenberger | Professor Colby |
| 24 | The Kryptonite Girl! | cover reprint (on interior page) | 1 | pencils: Curt Swan; inks: Stan Kaye; letters: Ira Schnapp | |
| 25 | The Kryptonite Girl! | comic story | 9 | script: Jerry Siegel; pencils: Kurt Schaffenberger; inks: Kurt Schaffenberger | Duke (Lucy's dog) |
| 26 | Lois Lane's Teen-Age Romance with Superman! | cover reprint (on interior page) | 1 | pencils: Kurt Schaffenberger; inks: Kurt Schaffenberger; letters: Ira Schnapp | Lois Lane; Superman; Justice of the Peace |
| 27 | The Romance of Superbaby and Baby Lois! | comic story | 9 | script: Leo Dorfman; pencils: Kurt Schaffenberger; inks: Kurt Schaffenberger | Lois Lane; Superman [also appears as Clark Kent]; Jimmy Olsen; Lucy Lane (cameo); Perry White (cameo) |
| 28 | I Am Curious (Black)! | cover reprint (on interior page) | 1 | pencils: Curt Swan; inks: Murphy Anderson; letters: Gaspar Saladino | Lois Lane; Superman; Thorn (inset) |
| 29 | I Am Curious (Black)! | comic story | 14 | script: Robert Kanigher; pencils: Werner Roth; inks: Vince Colletta; letters: Milt Snapinn | Lois Lane; Superman [also appears as Clark Kent]; Benny the Beret; Dave Stevens |
| 30 | Part III - 1986-1999: Lois and Clark | foreword, introduction, preface, afterword | 2 | letters: typeset | |
| 31 | Introducing -- Lois Lane! | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Superman [Clark Kent; Kal-El]; Lois Lane |
| 32 | The Story of the Century! | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: Dick Giordano; colors: Tom Ziuko; letters: John Costanza | Superman [Clark Kent; Kal-El]; Lois Lane; Perry White; Jimmy Olsen; Lex Luthor; Mr. Guthrie |
| 33 | - | illustration | 1 | | |
| 34 | Lois Lane | comic story | 8 | script: John Byrne, Roger Stern; pencils: Kurt Schaffenberger; inks: Jerry Ordway; colors: Scotese; letters: Bill Oakley | Lois Lane; Perry White; Superman [Clark Kent; Kal-El]; Cholly (villain); George Kozak (villain, introduction) |
| 35 | At Long Last... the Secret Revealed! | cover reprint (on interior page) | 1 | pencils: Kerry Gammill; inks: Brett Breeding; colors: Brett Breeding; letters: Todd Klein | Lois Lane; Superman [Clark Kent; Kal-El] |
| 36 | Secrets in the Night | comic story | 21 | script: Roger Stern; pencils: Bob McLeod; inks: Bob McLeod; colors: Glenn Whitmore; letters: Bill Oakley | Superman [Clark Kent; Kal-El]; Lois Lane; Ms. Fenster; the Crone; Silver Banshee [Siobhan McDougal] (villain); Blaze [Angelica Blaze] (villain); Baron Sunday (villain) |
| 37 | - | cover reprint (on interior page) | 1 | pencils: Leonard Kirk; inks: Karl Story | Lois Lane |
| 38 | Lois Lane | comic story | 22 | script: Barbara Kesel; pencils: Amanda Conner; inks: Jimmy Palmiotti; colors: John Kalisz, Digital Chameleon; letters: Gaspar Saladino | Lois Lane; Superman [Clark Kent]; Sarge Steel; Doctor Bruin |
| 39 | - | illustration | 1 | | |
| 40 | Part IV - 2000-Present: Twenty-First Century Lois | foreword, introduction, preface, afterword | 2 | letters: typeset | |
| 41 | This Looks Like a Job For... Batman & Lois! | cover reprint (on interior page) | 1 | pencils: Ed McGuinness; inks: Cam Smith; colors: Richard Horie, Tanya Horie | Batman [Bruce Wayne]; Lois Lane |
| 42 | With This Ring... | comic story | 22 | script: Jeph Loeb; pencils: Ed McGuinness; inks: Cam Smith; colors: Richard Horie, Tanya Horie; letters: Comicraft | Superman [Clark Kent]; Batman [Bruce Wayne]; Lois Lane; Pa Kent; Ma Kent; Krypto; Sam Lane; Ella Lane; Perry White; Jimmy Olsen |
| 43 | A Day in the Life | cover reprint (on interior page) | 1 | pencils: Adam Hughes; inks: Adam Hughes; colors: Adam Hughes | Wonder Woman; Lois Lane; Superman |
| 44 | She's a Wonder! | comic story | 22 | script: Phil Jimenez, Joe Kelly; pencils: Phil Jimenez; inks: Andy Lanning; colors: Trish Mulvihill, Heroic Age; letters: Comicraft | Perry White; Jimmy Olsen; Etta Candy Trevor; Steve Trevor; Lois Lane; Wonder Woman; Troia; Vicky Vale; Tawny Young; Lia Briggs; Linda Park; Lex Luthor; Trevor Barnes; Oscar Mayer; Sebastian Ballesteros; Silver Swan |
| 45 | Casualty of War | cover reprint (on interior page) | 1 | pencils: Gene Ha; inks: Gene Ha; colors: Art Lyon | Lois Lane |
| 46 | Battery, Part Five | comic story | 22 | script: Greg Rucka; pencils: Matthew Clark, Renato Guedes; inks: Andy Lanning; colors: Tanya Horie, Richard Horie; letters: Rob Leigh | Superman [Clark Kent; Kal-El]; Lois Lane (shot); Lt. Lupe Leocadio; Skeeter [Sgt. Scott Laughlin]; Beau Wright; PFC Damon Carter (dies); Alex Allston; Alexandra Allston; Miss Colby; Ruin; Xlim (Replikon's son) |
| 47 | - | illustration | 1 | | |
| 48 | Patience-Centered Care | comic story | 10 | script: Kathryn Immonen; pencils: Tonči Zonjić; inks: Tonči Zonjić; colors: Tonči Zonjić; letters: Travis Lanham | Superman [Clark Kent; Kal-El]; Lois Lane; Perry White |
| 49 | Part V - 1957-1985 Imaginary & Out-of-Continuity Tales | foreword, introduction, preface, afterword | 2 | letters: typeset | |
| 50 | The Wife of Superman! | cover reprint (on interior page) | 1 | pencils: Curt Swan; inks: Stan Kaye; letters: Ira Schnapp | Larry Kent; Carole Kent |
| 51 | The Wife of Superman! | comic story | 8 | script: Jerry Siegel; pencils: Kurt Schaffenberger; inks: Kurt Schaffenberger | Larry Kent; Carole Kent |
| 52 | Superman Takes a Wife! | cover reprint (on interior page) | 1 | pencils: José Luis García-López; inks: Dick Giordano; colors: Tatjana Wood | Superman (of Earth-2); Lois Lane (of Earth-2) |
| 53 | Superman Takes a Wife! | comic story | 22 | script: Cary Bates; pencils: Curt Swan; inks: Joe Giella; colors: Tatjana Wood; letters: Ben Oda | Superman [Kal-L; also as Clark Kent]; Lois Lane (of Earth-2); Colonel Future; The Wizard; The Mechanical Marauders; Jimmy Olsen (of Earth-2); George Taylor; Suzie Tompkins; Lucille Tompkins; Jor-L (statue); Lora (statue) |
| 54 | - | cover reprint (on interior page) | 1 | pencils: Frank Quitely; inks: Frank Quitely; colors: Jamie Grant | |
| 55 | Superman's Forbidden Room | comic story | 22 | script: Grant Morrison; pencils: Frank Quitely; inks: Jamie Grant; colors: Jamie Grant; letters: Phil Balsman | Superman Robots; Kal Kent (Superman of 853,450 AD); Unknown Superman of 4500 AD |
| 56 | - | cover reprint (on interior page) | 1 | pencils: Frank Quitely; inks: Frank Quitely; colors: Jamie Grant | |
| 57 | Sweet Dreams, Superwoman... | comic story | 22 | script: Grant Morrison; pencils: Frank Quitely; inks: Jamie Grant; colors: Jamie Grant; letters: Phil Balsman | Krull; Samson; Atlas; Tyrannko; Ultrasphinx |
| 58 | Cover Gallery: 75 Years of Lois Lane | table of contents | 1 | letters: typeset | |
| 59 | - | cover reprint (on interior page) | 1 | pencils: Wayne Boring; inks: Stan Kaye | Superman; Lois Lane |
| 60 | - | cover reprint (on interior page) | 1 | pencils: Wayne Boring; inks: Stan Kaye; colors: Jack Adler | Superman [Clark Kent]; Lois Lane |
| 61 | The Witch of Metropolis! | cover reprint (on interior page) | 1 | pencils: Curt Swan; inks: Stan Kaye; letters: Ira Schnapp | |
| 62 | Superman and Lois Lane, Newlyweds! | cover reprint (on interior page) | 1 | pencils: Kurt Schaffenberger; inks: Kurt Schaffenberger; letters: Ira Schnapp | |
| 63 | Splitsville for Lois and Superman! | cover reprint (on interior page) | 1 | pencils: Curt Swan; inks: Neal Adams; letters: Ira Schnapp | Lois Lane; Superman; Perry White |
| 64 | Trapped By... the Justice League? | cover reprint (on interior page) | 1 | pencils: Dick Giordano; inks: Dick Giordano; letters: Gaspar Saladino | Lois Lane; miniature Justice League clones [Superman; Batman; Black Canary; Hawkman; Green Lantern; Flash; Green Arrow; Aquaman] |
| 65 | Finally-- Some Time to Be Alone Together! | cover reprint (on interior page) | 1 | pencils: Dan Jurgens; inks: Brett Breeding; colors: Brett Breeding; letters: Todd Klein | Superman [Clark Kent; Kal-El]; Lois Lane |
| 66 | - | cover reprint (on interior page) | 1 | pencils: Dan Jurgens; inks: Jerry Ordway; colors: Glenn Whitmore | Superman; Lois Lane |
| 67 | Superman vs. Lois Lane! | cover reprint (on interior page) | 1 | pencils: Ed McGuinness; inks: Cam Smith; colors: Richard Horie, Tanya Horie | Superman; Parasite [as Lois Lane] |
| 68 | Lois Lane | cover reprint (on interior page) | 1 | pencils: Adam Hughes; inks: Adam Hughes; colors: Adam Hughes | Lois Lane |
| 69 | - | cover reprint (on interior page) | 1 | pencils: Tim Sale; inks: Tim Sale | Lois Lane; Jimmy Olsen |
| 70 | - | cover reprint (on interior page) | 1 | pencils: José Luis García-López; inks: José Luis García-López; colors: Trish Mulvihill | Superman [Clark Kent; Kal-El]; Lois Lane |
| 71 | - | blank page(s) | 1 | | |
| 72 | - | illustration | 2 | pencils: Frank Quitely; inks: Jamie Grant | |
| 73 | - | illustration | 1 | | |
| 74 | - | promo (ad from the publisher) | 0 | letters: typeset | |