| 0 | - | cover | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin; letters: Harvey Kurtzman | |
| 1 | Table of Contents | table of contents | 2 | letters: typeset | |
| 2 | Introduction... | foreword, introduction, preface, afterword | 5 | script: Mark Evanier; colors: Marie Severin | |
| 3 | Racing Sheet | cover reprint (on interior page) | 1 | colors: Marie Severin | |
| 4 | - | promo (ad from the publisher) | 1 | pencils: Will Elder; inks: Will Elder | |
| 5 | Mickey Rodent! | comic story | 7 | script: Harvey Kurtzman; pencils: Will Elder; inks: Will Elder; colors: Marie Severin; letters: Jim Wroten, Bill Elder | Mickey Rodent; Darnold Duck; Goony; Horace Horszneck; Pluted Pup; Minny Rodent; zookeeper; Professor |
| 6 | - | letters page | 1 | script: Harvey Kurtzman | |
| 7 | Supermarkets! | comic story | 8 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Mr. Sturdley; Mrs. Sturdley; Superman (cameo) |
| 8 | Puzzle Pages! | activity | 5 | script: Harvey Kurtzman; pencils: Will Elder; inks: Will Elder; colors: Marie Severin | |
| 9 | - | promo (ad from the publisher) | 1 | pencils: Reed Crandall; inks: Reed Crandall; colors: Marie Severin | |
| 10 | The Cane Mutiny! | comic story | 6 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Willie Wonte; Lt. Feefer; Captain DeBris; Captain Kweeg; Van; Lt. Whitewald; Lt. Christian; Captain Bligh |
| 11 | Drawrof | text article | 1 | script: Harvey Kurtzman | |
| 12 | Composition | cover reprint (on interior page) | 1 | letters: typeset | |
| 13 | No, I Said! You Can't Have My Copy of Mad! | promo (ad from the publisher) | 1 | pencils: Will Elder; inks: Will Elder | |
| 14 | Katchandhammer Kids! | comic story | 8 | script: Harvey Kurtzman; pencils: Will Elder; inks: Will Elder; colors: Marie Severin | Hans Katchandhammer; Feetz Katchandhammer; Der Kapitan; Inspektor; boat company man; Mamma |
| 15 | Sound Effects! | comic story | 7 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Kane Keen; Joe Arrrgh |
| 16 | - | promo (ad from the publisher) | 1 | pencils: Reed Crandall; inks: Reed Crandall; colors: Marie Severin | |
| 17 | - | letters page | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | |
| 18 | Bop | text article | 1 | script: Harvey Kurtzman | |
| 19 | Paul Revere's Ride! | comic story | 6 | script: Henry Wadsworth Longfellow, Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | |
| 20 | Cowboy! | comic story | 5 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Lance Sterling; John Smurd |
| 21 | Smithson John & Co. | cover reprint (on interior page) | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman | Alfred [Alfred E. Neuman] |
| 22 | - | letters page | 1 | script: Harvey Kurtzman | |
| 23 | Poopeye! | comic story | 8 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Poopeye; Mazola Oil; Swee'back [Mad-Man]; Mammy Jokeum; Mammy's son; Melvin of the Apes; Superduperman [Clark Bent]; Windy |
| 24 | Slow Motion! | comic story | 6 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | |
| 25 | Comic Book Ads! | comic story | 5 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | |
| 26 | Subscription Ads | promo (ad from the publisher) | 3 | colors: Marie Severin | |
| 27 | Under the Waterfront! | comic story | 6 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Terry; Joey; John Friendly; Charlie; Edie |
| 28 | - | text article | 1 | script: Harvey Kurtzman | |
| 29 | Special Art Issue | cover reprint (on interior page) | 1 | pencils: Harvey Kurtzman; inks: Harvey Kurtzman; colors: Marie Severin | Bill Elder ? |
| 30 | Special Art Issue | foreword, introduction, preface, afterword | 1 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder | Bill Elder |
| 31 | The Child! | comic story | 3 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Bill Elder |
| 32 | Mad Reader Advertisement | promo (ad from the publisher) | 1 | letters: typeset | |
| 33 | The Boy! | comic story | 4 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder | |
| 34 | The Young Artist! | comic story | 5 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder | Jack Webb; Marilyn Monroe; Mona Lisa; George Washington |
| 35 | Mad Mumblings | letters page | 0.75 | script: Harvey Kurtzman | |
| 36 | Statement of Ownership | statement of ownership | 0.25 | script: Lyle Stuart | |
| 37 | The Commercial Artist! | comic story | 6 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder | |
| 38 | The Old Pro! [Mole!] | comic story | 7 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Bill Elder; Melvin Mole |
| 39 | Senility! | comic story | 1 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Bill Elder |
| 40 | Introducing E. C.'s Sixth "New Direction" Magazine | promo (ad from the publisher) | 1 | pencils: Johnny Craig; inks: Johnny Craig; colors: Marie Severin | |
| 41 | Think | cover reprint (on interior page) | 1 | letters: typeset | |
| 42 | E. C.'s New Direction One-Two-Punch Mags! | promo (ad from the publisher) | 1 | pencils: Johnny Craig, Jack Kamen; inks: Johnny Craig, Jack Kamen | |
| 43 | Important Announcement | text article | 1 | letters: typeset | |
| 44 | Gopo Gossum! | comic story | 6 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Gopo Gossum; Simple J. Baloney [Joe McCarthy]; Alphonse Alligator [Winston Churchmouse]; Tideland Owl [Marshland Tito]; Ol' Tortoise [Mendup France]; Corky Porcupine [Waterhole Nehru]; Ol' Bloodhound [Change-Ki-Check]; Rackleddy Coon [Chew-An-Play]; Mouse [Georgia Melloncough]; Darnold Duck; Mickey |
| 45 | Mad Mumblings | letters page | 1 | script: Harvey Kurtzman | |
| 46 | Scenes We'd... Like to See! | comic story | 9 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Snirdingbash; Lance Sterling; Gwathmey |
| 47 | Ripup's Believe It or Don't | comic story | 3 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | |
| 48 | The Barefoot Nocountessa! | comic story | 7 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Harry Drawers [Humphrey Yogurt]; The Nocountessa [Ava Nother]; Edward Kirks; Alberto Banano; Count Vincenzo-Torlato-Pizzaria; Melvin Cowznowski |
| 49 | Mad Reader Advertisement | promo (ad from the publisher) | 1 | letters: typeset | |
| 50 | Here Is the Very Important Announcement | text article | 1 | letters: typeset | |
| 51 | - | cover reprint (on interior page) | 1 | pencils: Harvey Kurtzman; inks: Harvey Kurtzman | Socrates; Napoleon; Sigmund Freud; Marilyn Monroe; Alexander The Great; Rembrandt; Galileo; Lassie; Tom Swift; Columbus; Caesar; Buffalo Bill; Alfred L. Neuman; Melvin Cowznowski [Alfred E. Neuman]; Copernicus; Louis Pasteur; Ludwig Van Beethoven |
| 52 | Headache? Cold Misery? | comic story | 1 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder | |
| 53 | Extremely Important Message from the Editors | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman | |
| 54 | She Wanted to Drown Her Troubles | comic story | 1 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood | Jane Outsell |
| 55 | Contents | table of contents | 1 | script: Harvey Kurtzman | Roger Price; Bernard Shir-Cliff; Ernie Kovacs; Ira Wallach |
| 56 | I Dreamed I Walked down 5th Avenue in My Ironmaidenfit | comic story | 0.5 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis | |
| 57 | Letters Dept. | letters page | 1 | script: Harvey Kurtzman | |
| 58 | Are You Ever Lovely to Love? | comic story | 0.5 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder | |
| 59 | Is a Trip to the Moon Possible? | comic story | 10 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood | Dr. X Fline Saucer; Captain Buck Roger; Melvin Cowznowski; Commander Zork Argh |
| 60 | Report from Russia | text article | 1 | script: Hans Christian Andersen | Tel-Tapper-Phoner; Watchbug |
| 61 | Out of the Frying Pan and into the Soup | text story | 3 | script: Ira Wallach; pencils: Bernie Krigstein; inks: Bernie Krigstein | Ernest Heminghaw [Pappa]; Private First Class; Pierre; Mignonette; a driver |
| 62 | Wrestling | comic story | 10 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis | Kid Kindyouth; Offensive Herman; Art Rottencore; Reggie Spoilsport; Tom Strongheart; Dick Stoutfellow; Yukon Klondike; Antonio Rockingchair; Gomez Addams (cameo); Morticia Addams (cameo); Pugsley Addams (cameo); Frankenstein's monster (cameo) |
| 63 | Comics Digest | comic story | 2 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder | Brunette; Dogwood; Punjoke; Little Orphan Melvin; Daddy Peacebucks; Little Melvin Rooney; Smilin' Melvin; Upwind Johnson; Lil' Ab'r; Mammy Jokeum; Dick Tracing; Chief; Junior; Popcorn kids; Manduck The Magician; Loathar |
| 64 | Classy Crimes #138: Who Put the Strichnine in Mrs. Murphy's Husband? | text story | 3 | script: Bernard Shir-Cliff; pencils: Bill Elder; inks: Bill Elder | Dr. Milo Quackenbush; Francis L. Guteberger; Alfred L. Neuman; Seamus Murphy; Voona Murphy; Vasily Vaselodovich Orang-outang; Fothergill; Rosencrantz |
| 65 | Anyone Can Build This Coffee Table | comic story | 3 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis | |
| 66 | Is This Your Life? | comic story | 9 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder | Raoul Phedwards; Melvin Furd; Shiloh Culpepper; Sabrina Voom; Sheldon Scrounge; Alfred L. Neuman; Brunhilda Furd; Furd children; Furd's mother; Furd's father; Furd's sister; Furd's brother; Lone Ranger (cameo); Snap (cameo); Crackle (cameo); Pop (cameo); Santa Claus (cameo); Smith Brothers (cameo); |
| 67 | Tom Swifft and His Electric Ping Pong Ball | text story | 2 | script: Ernie Kovacs; pencils: Bill Elder; inks: Bill Elder | Tom Swifft; Professor Harding; Six-Torso [Ramona Popkin] |
| 68 | A Guide for Future Job Hunters | comic story | 1 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman | |
| 69 | How to Get the Job You Want by Thinking Positively and Also Get Ahead by Learning My Five Rules That Will Give You a New and Unbelievable Positive Personality and Help You Achieve Success | text article | 2 | script: Roger Price; pencils: Harvey Kurtzman; inks: Harvey Kurtzman | |
| 70 | Vera's Cruz | comic story | 10 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis | Burt Lambaster; Gary Chickencooper; Seezer Romeo; Emperor Maxamillion; Denice Parcel; Melvin Cowznowski; Sarita Vavavoom |
| 71 | If You Suffer Pain | comic story | 0.11 | script: Harvey Kurtzman; pencils: Harvey Kurtzman; inks: Harvey Kurtzman | Melvin Coznowski [Alfred E. Neuman] |
| 72 | When the Talk Turns to Books Do You Find Yourself Saying: "Hoo Hah?" | promo (ad from the publisher) | 0.11 | letters: typeset | |
| 73 | Pictoquiz | activity | 1.45 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis | Alfred E. Neuman; Wanda Furd |
| 74 | Are You Walking Around Like a Human Question Mark? | comic story | 0.33 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder | |
| 75 | In These Danger Periods Your Skin "Dies" a Little | comic story | 1 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis | Camenbert, Duchess of Fromage |