| 0 | - | cover | 1 | pencils: Jessica Fong; inks: Jessica Fong; colors: Jessica Fong | Poison Ivy |
| 1 | - | credits, title page | 1 | pencils: Marcio Takara; inks: Marcio Takara; colors: Arif Prianto | Poison Ivy |
| 2 | - | credits, title page | 2 | pencils: Dan Mora; inks: Dan Mora; colors: Dan Mora | Poison Ivy [Pamela Isley] |
| 3 | - | credits, title page | 1 | letters: typeset | |
| 4 | Prologue | recap | 1 | letters: typeset | |
| 5 | - | illustration | 1 | | |
| 6 | Photosynthesis | comic story | 8 | script: G. Willow Wilson; pencils: Dani; inks: Dani; colors: Trish Mulvihill; letters: Hassan Otsmane-Elhaou | Poison Ivy [Pamela Isley]; The Gardener [Bella Garten] |
| 7 | Poison Ivy #1 | cover reprint (on interior page) | 1 | pencils: Jessica Fong; inks: Jessica Fong; colors: Jessica Fong | Poison Ivy |
| 8 | Chapter One. Landscaping. | credits, title page | 1 | letters: typeset | |
| 9 | Chapter One | comic story | 22 | script: G. Willow Wilson; pencils: Marcio Takara; inks: Marcio Takara; colors: Arif Prianto; letters: Hassan Otsmane-Elhaou | Poison Ivy; Harley Quinn |
| 10 | Poison Ivy #2 | cover reprint (on interior page) | 1 | pencils: Jessica Fong; inks: Jessica Fong; colors: Jessica Fong | Poison Ivy |
| 11 | Chapter Two. A Bite to Eat. | credits, title page | 1 | letters: typeset | |
| 12 | Chapter Two | comic story | 22 | script: G. Willow Wilson; pencils: Marcio Takara; inks: Marcio Takara; colors: Arif Prianto; letters: Hassan Otsmane-Elhaou | Poison Ivy; Harley Quinn; The Gardener; Jenny Bolger |
| 13 | Poison Ivy #3 | cover reprint (on interior page) | 1 | pencils: Jessica Fong; inks: Jessica Fong; colors: Jessica Fong | Poison Ivy; Harley Quinn |
| 14 | Chapter Three. Yard Work. | credits, title page | 1 | letters: typeset | |
| 15 | Chapter Three | comic story | 22 | script: G. Willow Wilson; pencils: Marcio Takara; inks: Marcio Takara; colors: Arif Prianto; letters: Hassan Otsmane-Elhaou | Poison Ivy; Harley Quinn; The Gardener; Carrie; Jesslyn |
| 16 | Poison Ivy #4 | cover reprint (on interior page) | 1 | pencils: Jessica Fong; inks: Jessica Fong; colors: Jessica Fong | Poison Ivy [Pamela Isley] |
| 17 | Chapter Four. Horrible Bosses. | credits, title page | 1 | letters: typeset | |
| 18 | Chapter Four | comic story | 22 | script: G. Willow Wilson; pencils: Marcio Takara; inks: Marcio Takara; colors: Arif Prianto; letters: Hassan Otsmane-Elhaou | Poison Ivy [Pamela Isley]; Harley Quinn [Harleen Quinzel]; George Halloran; Jesslyn; Timothy |
| 19 | Poison Ivy #5 | cover reprint (on interior page) | 1 | pencils: Jessica Fong; inks: Jessica Fong; colors: Jessica Fong | Floronic Man [Jason Woodrue]; Poison Ivy [Pamela Isley] (photo); Harley Quinn [Harleen Quinzel] (photo) |
| 20 | Chapter Five. Dead Reckoning. | credits, title page | 1 | letters: typeset | |
| 21 | Chapter Five | comic story | 22 | script: G. Willow Wilson; pencils: Marcio Takara, Brian Level; inks: Marcio Takara, Stefano Gaudiano; colors: Arif Prianto; letters: Hassan Otsmane-Elhaou | Poison Ivy [Pamela Isley]; Floronic Man [Jason Woodrue]; Batman [Bruce Wayne] (hallucination) |
| 22 | Poison Ivy #6 | cover reprint (on interior page) | 1 | pencils: Jessica Fong; inks: Jessica Fong; colors: Jessica Fong | Poison Ivy |
| 23 | Chapter Six. Old Wounds. | credits, title page | 1 | letters: typeset | |
| 24 | Chapter Six | comic story | 22 | script: G. Willow Wilson; pencils: Brian Level, Marcio Takara; inks: Jay Leisten, Brian Level, Marcio Takara; colors: Arif Prianto; letters: Hassan Otsmane-Elhaou | Poison Ivy [Pamela Isley]; Batman [Bruce Wayne] (hallucination); Harley Quinn; Floronic Man [Jason Woodrue]; bearded man; Jenny Bolger; Jesslyn |
| 25 | Appendix | credits, title page | 1 | letters: typeset | |
| 26 | i. {Abstract} | foreword, introduction, preface, afterword | 1 | letters: typeset | |
| 27 | Ophiocordyceps Lamia | comic story | 12 | script: G. Willow Wilson; pencils: Emma Ríos; inks: Emma Ríos; colors: Jordie Bellaire; letters: Hassan Otsmane-Elhaou | Poison Ivy [Pamela Isley; Ms. Berry]; Carl; Janet |
| 28 | ii. {Coda} Variant Cover Galleries | credits, title page | 1 | letters: typeset | |
| 29 | ii.a. Lethal Toxicology Variants | cover reprint (on interior page) | 2 | pencils: Nick Robles, Álvaro Martínez Bueno, Justine Frany, Seb McKinnon, Zoe Thorogood, Tula Lotay; inks: Nick Robles, Álvaro Martínez Bueno, Justine Frany, Seb McKinnon, Zoe Thorogood, Tula Lotay; colors: Nick Robles, Álvaro Martínez Bueno, Justine Frany, Seb McKinnon, Zoe Thorogood, Tula Lotay | Poison Ivy |
| 30 | ii.b. Poison Ivy #1 Variants | cover reprint (on interior page) | 4 | pencils: Warren Louw, Frank Cho, Dan Mora, Kris Anka, Josh Burns, Will Jack; inks: Warren Louw, Frank Cho, Dan Mora, Kris Anka, Josh Burns, Will Jack; colors: Warren Louw, Sabine Rich, Dan Mora, Kris Anka, Josh Burns, Will Jack | Poison Ivy |
| 31 | ii.c. Poison Ivy #2 Variants | cover reprint (on interior page) | 1 | pencils: Sweeney Boo, Jenny Frison, Claire Roe, Christian Ward; inks: Sweeney Boo, Jenny Frison, Claire Roe, Christian Ward; colors: Sweeney Boo, Jenny Frison, Jordie Bellaire, Christian Ward | Poison Ivy |
| 32 | ii.d. Poison Ivy #3 Variants | cover reprint (on interior page) | 1 | pencils: Stanley "Artgerm" Lau, Joëlle Jones, Joshua Middleton; inks: Stanley "Artgerm" Lau, Joëlle Jones, Joshua Middleton; colors: Stanley "Artgerm" Lau, Jordie Bellaire, Joshua Middleton | Poison Ivy |
| 33 | ii.e. Poison Ivy #4 Variants | cover reprint (on interior page) | 1 | pencils: Jenny Frison, Sozomaika, Amy Reeder, Matías Bergara; inks: Jenny Frison, Sozomaika, Amy Reeder, Matías Bergara; colors: Jenny Frison, Sozomaika, Amy Reeder, Matías Bergara | Poison Ivy |
| 34 | ii.f. Poison Ivy #5 Variants | cover reprint (on interior page) | 1 | pencils: Stjepan Šejić, David Talaski; inks: Stjepan Šejić, David Talaski; colors: Stjepan Šejić, David Talaski | Poison Ivy |
| 35 | ii.g. Poison Ivy #6 Variants | cover reprint (on interior page) | 1 | pencils: Jenny Frison, Warren Louw, Janaina Medeiros; inks: Jenny Frison, Warren Louw, Janaina Medeiros; colors: Jenny Frison, Warren Louw, Janaina Medeiros | Poison Ivy |
| 36 | iii. {Conception} Character Designs, Cover Sketches, and Commentary | credits, title page | 1 | letters: typeset | |
| 37 | Character Designs | illustration | 3 | pencils: Marcio Takara; inks: Marcio Takara; colors: Marcio Takara | |
| 38 | {Villain Era} Commentary | text article | 3.75 | script: G. Willow Wilson, Marcio Takara, Arif Prianto, Hassan Otsmane-Elhaou, Jessica Fong, Arianna Turturro | |
| 39 | Cover Sketches by Jessica Fong | illustration | 6.25 | pencils: Jessica Fong; inks: Jessica Fong; colors: Jessica Fong | |
| 40 | iv. {Fruiting Bodies} Biographies | text article | 2 | letters: typeset | |
| 41 | Humanity Had Its Chance | illustration | 1 | pencils: Nick Robles; inks: Nick Robles; colors: Nick Robles | Poison Ivy |