| 0 | - | cover | 1 | pencils: Michael Turner; inks: Mark Roslan; colors: Peter Steigerwald | Supergirl [Kara Zor-El] |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Aaron Lopresti; inks: Aaron Lopresti; colors: Hi-Fi | Codename: Assassin; General Sam Lane; Steel; Superboy [Kon-El]; Supergirl [Kara Zor-El]; Superman; Mon-El; Captain Atom; The Guardian [Jim Harper (clone)]; Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; General Zod; Atlas |
| 2 | Blood-Sisters: A Tale of Old Krypton | comic story | 12 | script: Sterling Gates, Greg Rucka; pencils: Fernando Dagnino; inks: Raúl Fernández; colors: Blond; letters: John J. Hill | Supergirl [Kara Zor-El]; Thara Ak-Var; Alura (cameo) |
| 3 | - | cover reprint (on interior page) | 1 | pencils: Fernando Dagnino; inks: Raúl Fernández; colors: Mazi | Supergirl; Mirabai |
| 4 | Codename: Patriot, Part 3 | comic story | 22 | script: Sterling Gates; pencils: Jamal Igle; inks: Jon Sibal; colors: Nei Ruffino; letters: Jared K. Fletcher | Supergirl; Ral-Dar; General Sam Lane; Atlas; Superman; Lois Lane; Guardian; Mon-El; Flamebird [Thara Ak-Var]; Nightwing [Chris Kent]; Perry White; Cat Grant; Mirabai; Reactron |
| 5 | - | cover reprint (on interior page) | 1 | pencils: Pere Pérez; inks: Pere Pérez; colors: Javier Mena | Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; Supergirl [Kara Zor-El] |
| 6 | The Hunt for Reactron, Part 1 | comic story | 22 | script: Greg Rucka, Sterling Gates; pencils: Pere Pérez; inks: Pere Pérez; colors: Javier Mena; letters: Rob Leigh | Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; Supergirl [Kara Zor-El]; Mon-El (on video screen); Guardian [Jim Harper clone]; The Science Police; Reactron; Metallo; Morgan Edge (on video screen); Lois Lane; Perry White; Catherine Grant; Squad K (cameo) |
| 7 | - | cover reprint (on interior page) | 1 | pencils: Joshua Middleton; inks: Joshua Middleton; colors: Joshua Middleton | Supergirl; Flamebird [Thara Ak-Var] |
| 8 | The Hunt for Reactron, Part 2 | comic story | 22 | script: Sterling Gates, Greg Rucka; pencils: Jamal Igle; inks: Jon Sibal; colors: Nei Ruffino; letters: Jared K. Fletcher | Supergirl [Kara Zor-El]; Cat Grant; Morgan Edge; Flamebird [Thara Ak-Var]; Nightwing [Chris Kent]; Squad K; Lois Lane; Lana Lang; Reactron; General Sam Lane |
| 9 | - | cover reprint (on interior page) | 1 | pencils: Cafu; inks: Cafu; colors: Santiago Arcas | Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; Supergirl [Kara Zor-El]; Reactron |
| 10 | The Hunt for Reactron, Part 3 | comic story | 22 | script: Greg Rucka, Sterling Gates; pencils: Pere Pérez; inks: Pere Pérez; colors: Javier Mena; letters: Rob Leigh | Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; Supergirl [Kara Zor-El]; Squad K [Colonel Percy Hazard (death); others]; General Sam Lane; Reactron; Lieutenant Hollister; Lois Lane; Lana Lang |
| 11 | - | cover reprint (on interior page) | 1 | pencils: Joshua Middleton; inks: Joshua Middleton; colors: Joshua Middleton | Supergirl [Kara Zor-El]; Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; Reactron |
| 12 | The Hunt for Reactron, Conclusion | comic story | 23 | script: Sterling Gates, Greg Rucka; pencils: Jamal Igle, Eduardo Pansica; inks: Jon Sibal, Júlio Ferreira; colors: Nei Ruffino, Pete Pantazis; letters: Jared K. Fletcher | Supergirl [Kara Zor-El]; Flamebird [Thara Ak-Var]; Nightwing [Chris Kent]; Reactron; Lana Lang; Lois Lane |
| 13 | Metallo & Reactron | character profile | 1 | script: James Robinson; pencils: Renato Guedes; inks: Jose W. Magalhaes; colors: David Curiel | Metallo; Reactron; Zor-El (inset) |
| 14 | - | cover reprint (on interior page) | 1 | pencils: Joshua Middleton; inks: Joshua Middleton; colors: Joshua Middleton | Supergirl [Kara Zor-El]; Alura |
| 15 | Pain and Responsibility | comic story | 23 | script: Sterling Gates; pencils: Matt Camp; inks: Matt Camp; colors: Nei Ruffino; letters: Jared K. Fletcher | Alura; Supergirl [Kara Zor-El]; Zor-El (flashback); Reactron; Tal-Ox; Dor-Ox; Lyra; Dyn-Xe; Superman (cameo, flashback); Brainiac (cameo, flashback); Commander Gor |
| 16 | - | cover reprint (on interior page) | 1 | pencils: Renato Guedes; inks: Renato Guedes; colors: Renato Guedes | Supergirl [Linda Lang]; Superwoman [Lucy Lane]; General Sam Lane |
| 17 | Secret Identities | comic story | 20 | script: Sterling Gates; pencils: Fernando Dagnino; inks: Raúl Fernández; colors: Blond; letters: Travis Lanham | Supergirl [Kara Zor-El; Linda Lang]; Squad K; Guardian; Lana Lang; Jessica Lowther; David Lowther |
| 18 | Second Born: The Secret Origin of Superwoman | comic story | 20 | script: Sterling Gates; pencils: Fernando Dagnino; inks: Raúl Fernández; colors: Blond; letters: Travis Lanham | Superwoman [Lucy Lane]; General Sam Lane; Lois Lane; Clark Kent (cameo); Ella Lane; Codename: Assassin (cameo) |
| 19 | - | cover reprint (on interior page) | 1 | pencils: Joshua Middleton; inks: Joshua Middleton; colors: Joshua Middleton | Supergirl [Linda Lang; Kara Zor-El]; Silver Banshee [Siobhan McDougal] |
| 20 | Song of the Silver Banshee | comic story | 20 | script: Sterling Gates; pencils: Fernando Dagnino; inks: Raúl Fernández; colors: Nei Ruffino, Ulises Arreola, Pete Pantazis; letters: Jared K. Fletcher | Supergirl [Linda Lang; Kara Zor-El]; Lana Lang; Inspector Mike Henderson; Silver Banshee [Siobhan McDougal] |
| 21 | - | cover reprint (on interior page) | 1 | pencils: Joshua Middleton; inks: Joshua Middleton; colors: Joshua Middleton | Supergirl [Kara Zor-El] |
| 22 | Death and the Family | comic story | 22 | script: Sterling Gates; pencils: Matt Camp; inks: Matt Camp; colors: Nei Ruffino; letters: Jared K. Fletcher | Supergirl [Kara Zor-El]; Silver Banshee; Lana Lang; Inspector Henderson |
| 23 | - | cover reprint (on interior page) | 1 | pencils: Michael Turner; inks: Mark Roslan; colors: Peter Steigerwald | Supergirl [Kara Zor-El] |
| 24 | Queen | comic story | 40 | script: Sterling Gates; pencils: Jamal Igle; inks: Jon Sibal, Mark McKenna; colors: Nei Ruffino, Pete Pantazis; letters: Jared K. Fletcher | Supergirl [Kara Zor-El]; General Sam Lane; Superwoman [Major Lucy Lane]; Mirabai; Codename: Assassin; Gangbuster; Insect Queen [Lana Lang]; Dr. Light [Kimiyo Hoshi] |
| 25 | A Hero's Journey | comic story | 6 | script: Jake Black, Helen Slater; pencils: Cliff Chiang; inks: Cliff Chiang; colors: Dave McCaig; letters: Jared K. Fletcher | Supergirl [Kara Zor-El]; Ron Troupe; Justice Society of America [Flash [Jay Garrick]; Green Lantern [Alan Scott]; Power Girl; Stargirl] (cameo); Teen Titans [Robin [Tim Drake]; Ravager; Wonder Girl [Cassandra Sandsmark]; Miss Martian; Blue Beetle [Jaime Reyes]; Kid Devil] (cameo); Cat Grant; Superwo |