| 0 | - | cover | 1 | pencils: Joshua Middleton; inks: Joshua Middleton; colors: Joshua Middleton | Supergirl; Flamebird [Thara Ak-Var] |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Aaron Lopresti; inks: Aaron Lopresti; colors: Hi-Fi | Codename: Assassin; General Sam Lane; Steel; Superboy [Kon-El]; Supergirl [Kara Zor-El]; Superman; Mon-El; Captain Atom; The Guardian [Jim Harper (clone)]; Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; General Zod; Atlas |
| 2 | Blood Sisters: A Tale of Old Krypton | comic story | 12 | script: Sterling Gates, Greg Rucka; pencils: Fernando Dagnino; inks: Raúl Fernández; colors: Blond; letters: John J. Hill | Supergirl [Kara Zor-El]; Thara Ak-Var; Alura (cameo) |
| 3 | - | cover reprint (on interior page) | 1 | pencils: Joshua Middleton; inks: Joshua Middleton; colors: Joshua Middleton | Supergirl |
| 4 | Guilding Day | comic story | 22 | script: Sterling Gates; pencils: Jamal Igle; inks: Jon Sibal; colors: Pete Pantazis; letters: Jared K. Fletcher | Supergirl [Kara Zor-El]; Zor-El (flashback); Alura; Lyra; Kal-El [Superman]; Jeq-Vay; Zal-Tel |
| 5 | - | cover reprint (on interior page) | 1 | pencils: Pere Pérez; inks: Pere Pérez; colors: Javier Mena | Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; Supergirl [Kara Zor-El] |
| 6 | The Hunt for Reactron, Part 1 | comic story | 22 | script: Greg Rucka, Sterling Gates; pencils: Pere Pérez; inks: Pere Pérez; colors: Javier Mena; letters: Rob Leigh | Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; Supergirl [Kara Zor-El]; Mon-El (on video screen); Guardian [Jim Harper clone]; The Science Police; Reactron; Metallo; Morgan Edge (on video screen); Lois Lane; Perry White; Catherine Grant; Squad K (cameo) |
| 7 | - | cover reprint (on interior page) | 1 | pencils: Joshua Middleton; inks: Joshua Middleton; colors: Joshua Middleton | Supergirl; Flamebird [Thara Ak-Var] |
| 8 | The Hunt for Reactron, Part 2 | comic story | 22 | script: Sterling Gates, Greg Rucka; pencils: Jamal Igle; inks: Jon Sibal; colors: Nei Ruffino; letters: Jared K. Fletcher | Supergirl [Kara Zor-El]; Cat Grant; Morgan Edge; Flamebird [Thara Ak-Var]; Nightwing [Chris Kent]; Squad K; Lois Lane; Lana Lang; Reactron; General Sam Lane |
| 9 | - | cover reprint (on interior page) | 1 | pencils: Cafu; inks: Cafu; colors: Santiago Arcas | Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; Supergirl [Kara Zor-El]; Reactron |
| 10 | The Hunt for Reactron, Part 3 | comic story | 22 | script: Greg Rucka, Sterling Gates; pencils: Pere Pérez; inks: Pere Pérez; colors: Javier Mena; letters: Rob Leigh | Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; Supergirl [Kara Zor-El]; Squad K [Colonel Percy Hazard (death); others]; General Sam Lane; Reactron; Lieutenant Hollister; Lois Lane; Lana Lang |
| 11 | - | cover reprint (on interior page) | 1 | pencils: Joshua Middleton; inks: Joshua Middleton; colors: Joshua Middleton | Supergirl [Kara Zor-El]; Nightwing [Chris Kent]; Flamebird [Thara Ak-Var]; Reactron |
| 12 | The Hunt for Reactron, Conclusion | comic story | 23 | script: Sterling Gates, Greg Rucka; pencils: Jamal Igle, Eduardo Pansica; inks: Jon Sibal, Júlio Ferreira; colors: Nei Ruffino, Pete Pantazis; letters: Jared K. Fletcher | Supergirl [Kara Zor-El]; Flamebird [Thara Ak-Var]; Nightwing [Chris Kent]; Reactron; Lana Lang; Lois Lane |
| 13 | - | cover reprint (on interior page) | 1 | pencils: Joshua Middleton; inks: Joshua Middleton; colors: Joshua Middleton | Supergirl [Kara Zor-El]; Alura |
| 14 | Pain and Responsibility | comic story | 23 | script: Sterling Gates; pencils: Matt Camp; inks: Matt Camp; colors: Nei Ruffino; letters: Jared K. Fletcher | Alura; Supergirl [Kara Zor-El]; Zor-El (flashback); Reactron; Tal-Ox; Dor-Ox; Lyra; Dyn-Xe; Superman (cameo, flashback); Brainiac (cameo, flashback); Commander Gor |
| 15 | Supergirl | character profile | 1 | script: Sterling Gates; pencils: Jamal Igle; inks: Jon Sibal; colors: Nei Ruffino | Supergirl [Kara Zor-El; Linda Lang]; Zor-El (inset); Alura (inset); Brainiac (inset); Lana Lang (inset) |
| 16 | Alura and the Guilds of New Krypton | character profile | 1 | script: James Robinson; pencils: Jamal Igle; inks: Jon Sibal; colors: Nei Ruffino | Alura Zor-El; Lara (inset); Jor-El (inset); Superman (inset) |
| 17 | Metallo & Reactron | character profile | 1 | script: Sterling Gates; pencils: Fernando Dagnino; inks: Raúl Fernández; colors: Pete Pantazis | Metallo; Reactron; Zor-El (inset) |