| 0 | The Man of Steel's Deadliest Enemies! | cover | 1 | pencils: Dan Jurgens; inks: Norm Rapmund; colors: Patrick Martin | Lex Luthor; Doomsday; Brainiac; Cyborg Superman; Atomic Skull; Metallo; Toyman; Silver Banshee; Parasite |
| 1 | Superman Villains Secret Files and Origins | credits, title page | 1 | pencils: Stuart Immonen; inks: José Marzán Jr.; colors: Tom McCraw | |
| 2 | A Child’s Garden of Villainy | comic story | 22 | script: Stuart Immonen; pencils: Stuart Immonen; inks: José Marzán Jr.; colors: Tom McCraw, Digital Chameleon; letters: Gaspar; editing: Joey Cavalieri, Maureen McTigue | Lex Luthor; Superman [Kal-El; a.k.a. Clark Kent]; Mr. Newton; Ms. Branche; Lena Luthor; Metallo; Brainiac; Doomsday; The Cyborg Superman; The Toyman |
| 3 | Metallo, Transforming Terror | character profile | 1 | script: Roger Stern; pencils: Phil Jimenez; inks: Phil Jimenez; colors: Tom McCraw, Digital Chameleon | Metallo |
| 4 | Lex Luthor, Never-Ending Evil | character profile | 1 | script: Roger Stern; pencils: John Byrne; inks: John Byrne; colors: Tom McCraw, Digital Chameleon | Lex Luthor |
| 5 | Atomic Skull and Cross Purposes | text article | 3 | script: Kevin Dooley; pencils: Curt Swan; inks: Dennis Janke | Atomic Skull |
| 6 | Crime & Merriment | text article | 5 | script: Evan Dorkin; pencils: Stephen DeStefano; inks: Stephen DeStefano; colors: Tom McCraw, Digital Chameleon | |
| 7 | Silver Banshee, Wayward Soul | character profile | 1 | script: Roger Stern; pencils: Joyce Chin; inks: Andy Lanning; colors: Tom McCraw, Digital Chameleon | Silver Banshee |
| 8 | Cyborg, Metallic Mass Murderer | character profile | 1 | script: Roger Stern; pencils: Dan Jurgens; inks: Norm Rapmund; colors: Tom McCraw, Digital Chameleon | The Cyborg Superman |
| 9 | Monsters in the Making | comic story | 2 | script: Dan Brereton; pencils: John McCrea; inks: John McCrea; colors: Tom McCraw, Digital Chameleon; letters: Kurt Hathaway | Simyan; Mokkari |
| 10 | My Dinner with the Lex | text article | 2 | script: Matt Brady | Lex Luthor |
| 11 | Brainiac, Terror from Space | character profile | 1 | script: Roger Stern; pencils: Dave Johnson; inks: Dave Johnson; colors: Digital Chameleon, Dave Johnson | Brainiac |
| 12 | Obsession, Love Hurts | character profile | 1 | script: Roger Stern; pencils: Stuart Immonen; inks: José Marzán Jr.; colors: Tom McCraw, Digital Chameleon | Obsession |
| 13 | Super Obsession | text article | 3 | script: Scott Sonneborn | |
| 14 | Rock, Stone-Cold Revenge | character profile | 1 | script: Roger Stern; pencils: Paul Ryan; inks: Jimmy Palmiotti; colors: Tom McCraw, Digital Chameleon | Rock |
| 15 | Mister Mxyzptlk, Interdimensional Irritant | character profile | 1 | script: Roger Stern; pencils: Evan Dorkin; inks: Evan Dorkin; colors: Tom McCraw, Digital Chameleon | Mister Mxyzptlk |
| 16 | Mainframe, Group Cyber-Mind | character profile | 1 | script: Roger Stern; pencils: Scot Eaton; inks: Jimmy Palmiotti; colors: Tom McCraw, Digital Chameleon | Mainframe |
| 17 | Maxima, Arrogant Aristocrat | character profile | 1 | script: Roger Stern; pencils: Amanda Conner; inks: Jimmy Palmiotti; colors: Tom McCraw, Digital Chameleon | Maxima |
| 18 | Atomic Skull, Radioactive Rampager | character profile | 1 | script: Roger Stern; pencils: Paul Ryan; inks: Jimmy Palmiotti; colors: Tom McCraw, Digital Chameleon | Atomic Skull |
| 19 | Riot, Mob Mentality | character profile | 1 | script: Roger Stern; pencils: Georges Jeanty; inks: Dexter Vines; colors: Tom McCraw, Digital Chameleon | Riot |
| 20 | Parasite, Your Power Is His | character profile | 1 | script: Roger Stern; pencils: Cully Hamner; inks: Cully Hamner; colors: Tom McCraw, Digital Chameleon | Parasite |
| 21 | Toyman, Craftsman of Death | character profile | 1 | script: Roger Stern; pencils: Ron Frenz; inks: Joe Rubinstein; colors: Tom McCraw, Digital Chameleon | Toyman |
| 22 | Super-Villains Time Line | text article | 2 | script: Roger Stern | |
| 23 | Doomsday, Irresistible Force | character profile | 1 | script: Roger Stern; pencils: Dan Jurgens; inks: Norm Rapmund; colors: Tom McCraw, Digital Chameleon | Doomsday |