| 0 | - | cover | 1 | pencils: José Luis García-López; inks: José Luis García-López; colors: Alex Sinclair | Superman; Lex Luthor |
| 1 | Superman vs. Lex Luthor | illustration | 1 | pencils: José Luis García-López | |
| 2 | - | credits, title page | 1 | pencils: Curt Swan; inks: Murphy Anderson | Lex Luthor |
| 3 | Contents | table of contents | 2 | letters: typeset | |
| 4 | Every Great Hero Needs an Equally Powerful Nemesis | foreword, introduction, preface, afterword | 2 | letters: typeset | |
| 5 | America at War | comic story | 13 | script: Jerry Siegel; pencils: Joe Shuster; inks: Paul Cassidy | Superman [Clark Kent]; Lois Lane; George Taylor; Luthor; General Lupo |
| 6 | The Titanic Thefts! | comic story | 10 | script: Bill Finger; pencils: Wayne Boring; inks: Stan Kaye | Superman [Clark Kent]; Lois Lane; Lex Luthor; Perry White |
| 7 | How Luthor Met Superboy! | comic story | 13 | script: Jerry Siegel; pencils: Al Plastino; inks: Al Plastino | Lex Luthor; Jonathan Kent [Pa Kent]; Martha Kent [Ma Kent]; Krypto; Lana Lang |
| 8 | The Army of Living Kryptonite Men! | comic story | 8 | script: Jerry Siegel; pencils: George Papp; inks: George Papp; letters: Joe Letterese | Superboy; Lex Luthor; Lana Lang; Jonathan Kent; Krypto; Lightning Lad; Cosmic Boy (cameo); Saturn Girl (cameo) |
| 9 | Part I: The Showdown Between Luthor and Superman! | comic story | 8 | script: Edmond Hamilton; pencils: Curt Swan; inks: George Klein | Superman; Lex Luthor; Lois Lane; Jimmy Olsen; Jor-El (flashback) |
| 10 | Part II: The Super-Duel! | comic story | 8.67 | script: Edmond Hamilton; pencils: Curt Swan; inks: George Klein | Superman; Lex Luthor; Jor-El (hallucination); Lara (hallucination) |
| 11 | The Luthor Nobody Knows! | comic story | 13 | script: Elliot S! Maggin; pencils: Curt Swan; inks: Bob Oksner | Lex Luthor; Superman; Clark Kent; Roy Raymond; Perry White; Superboy; Smallville Police Chief Douglas Parker |
| 12 | Luthor Unleashed! | comic story | 28 | script: Cary Bates; pencils: Curt Swan; inks: Murphy Anderson; colors: Tony Tollin; letters: Ben Oda | Superman; Lex Luthor; Ardora; Lex Luthor, Jr. |
| 13 | The New Luthor | illustration | 1 | pencils: George Pérez; inks: George Pérez; colors: Drew R. Moore | Lex Luthor |
| 14 | The Einstein Connection! | comic story | 16 | script: Elliot S! Maggin; pencils: Curt Swan; inks: Al Williamson; colors: Gene D'Angelo; letters: Ed King | Superman; Lex Luthor; Perry White |
| 15 | Enemy Mine... | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: Dick Giordano; colors: Tom Ziuko; letters: John Costanza | Superman [Clark Kent; Kal-El]; Lois Lane; Mayor Frank Berkowitz; Yvette; Lex Luthor |
| 16 | Metropolis 900 Mi | comic story | 7 | script: John Byrne; pencils: John Byrne; inks: Karl Kesel; colors: Tom Ziuko; letters: John Costanza | Jenny Hubbard; Aggie; Pam; Lex Luthor; Cynthia |
| 17 | Checkmate | comic story | 22 | script: Dan Jurgens; pencils: Ron Frenz; inks: Joe Rubinstein; colors: Glenn Whitmore, Digital Chameleon; letters: John Costanza | Superman Blue [Clark Kent; Kal-El]; Lois Lane; Perry White; Lex Luthor; Lena Luthor; Contessa Erica Alexandra del Portenza; Doctor Cordova; Lionel Luthor; Lillian Luthor; Casey Griggs; Elaine Griggs; Lena Griggs; Mayor Frank Berkowitz |
| 18 | Triumph Over Tragedy | comic story | 12 | script: Jeph Loeb; pencils: Tony Harris; inks: Ray Snyder; colors: Tanya Horie, Richard Horie; letters: Comicraft | Lex Luthor; Cat Grant; Superman; Perry White; Brainiac 13 |
| 19 | Lex Luthor | character profile | 1 | script: Frank Pittarese; pencils: Lee Bermejo; inks: Lee Bermejo; colors: Tom McCraw, Digital Chameleon | Lex Luthor |
| 20 | - | illustration | 1 | pencils: Ron Frenz; inks: Joe Rubinstein; colors: Glenn Whitmore, Digital Chameleon | Lex Luthor |
| 21 | Mad Scientist. Armored Criminal. Ruthless Businessman. Corrupt President. | promo (ad from the publisher) | 1 | pencils: José Luis García-López | Superman |