| 0 | Cain | cover | 1 | pencils: Bernie Wrightson; inks: Bernie Wrightson; colors: Bernie Wrightson; letters: Todd Klein | Abel; Cain; Gregory (gargoyle) |
| 1 | Cain | foreword, introduction, preface, afterword | 1 | pencils: Bernie Wrightson; inks: Bernie Wrightson | Cain; Gregory (gargoyle) |
| 2 | Welcome Back to... The House of Mystery | comic story | 7 | script: Neil Gaiman; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Tom Ziuko; letters: Todd Klein | Abel; Cain; Gregory (gargoyle); Phantom Stranger |
| 3 | - | table of contents | 1 | pencils: Bernie Wrightson; inks: Bernie Wrightson; colors: Tom Ziuko; letters: Todd Klein | Abel; Cain |
| 4 | The Gourmet | comic story | 6 | script: Steve Skeates; pencils: Berni Wrightson; inks: Berni Wrightson; colors: Tom Ziuko | Abel; Cain (story host); Hormsley (servant); Vernon Glute |
| 5 | Sno' Fun! | comic story | 9 | script: Sergio Aragonés; pencils: Wally Wood; inks: Wally Wood; colors: Tom Ziuko | Cain (story host); Gregory (gargoyle); Dr. Wallace B. Peterson (scientist); Professor Strauss (scientist) |
| 6 | Nightmare | comic story | 12 | script: Jack Oleck; pencils: Neal Adams; inks: Dick Giordano; colors: Tom Ziuko | Cain (story host); Judy; Judy's father; Miss Winter (governess); Pan (statue brought to life) |
| 7 | The Secret of the Egyptian Cat | comic story | 10 | script: Robert Kanigher; pencils: Berni Wrightson; inks: Berni Wrightson; colors: Tom Ziuko | Cain (story host); Isha (priestess); Konassos (sorcerer); Ra-Na (cat) |
| 8 | The House of Endless Years | comic story | 6.5 | script: Gerard Conway; pencils: Bill Draut; inks: Bill Draut; colors: Tom Ziuko | Cain (story host); Judy (girl); Neal (Peggy's brother); old hag; Peggy (girl); Tippy (Peggy's dog) |
| 9 | Cain's True Things You Didn't Know About The House of Mystery!!!! | comic story | 0.5 | script: Neil Gaiman; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Tom Ziuko; letters: Todd Klein | Cain |
| 10 | The Demon Within! | comic story | 7 | script: Joe Orlando, John Albano; pencils: Jim Aparo; inks: Jim Aparo; colors: Tom Ziuko; letters: Jim Aparo | Cain (story host); Gary Winters (boy who can become a monster); Gary Winters (Gary's father); Kathy Winters (Gary's sister); Mildred Winters (Gary's mother) |
| 11 | The Burning! | comic story | 8 | script: Jack Oleck; pencils: Mike Sekowsky; inks: Tom Palmer; colors: Tom Ziuko | Adam Strat; Cain (story host); Meg Cooper (witch) |
| 12 | His Name Is... Kane | comic story | 6.5 | script: Mike Friedrich; pencils: Gil Kane; inks: Wally Wood; colors: Tom Ziuko | Abel; Carmine Infantino; Gil Kane; Joe Orlando |
| 13 | Your Handy Cut-Out-and-Keep Guide to The House of Mystery!! | comic story | 0.5 | script: Neil Gaiman; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Tom Ziuko; letters: Todd Klein | |
| 14 | Oh, Mom! Oh, Dad! You've Sent Me Away to Summer Camp... and I'm So Sad! | comic story | 8 | script: Michael Fleisher, Maxene Fabe; pencils: Alex Niño; inks: Alex Niño; colors: Tom Ziuko; letters: Alex Niño | camp kids [Richard ("Richie", boy in wheelchair); Timmy; Tony; and others]; counselor Bill; counselor Dave; counselor Larry; head counselor Ressler |
| 15 | Molded in Evil | comic story | 6 | script: Ed Noonchester, George Kashdan; pencils: Berni Wrightson; inks: Berni Wrightson; colors: Tom Ziuko | Cain (story host); Clothilde (Pierre Gouny's wife); Pierre Gouny (sculptor) |