| 0 | Sherlock Holmes | cover | 1 | pencils: John Cassaday; inks: John Cassaday | Sherlock Holmes; Dr. Watson |
| 1 | Title Page and Credits | credits, title page | 3 | pencils: Aaron Campbell; inks: Aaron Campbell | |
| 2 | Sherlock Holmes | cover reprint (on interior page) | 1 | pencils: John Cassaday; inks: John Cassaday | Sherlock Holmes; Dr. Watson |
| 3 | The Trial of Sherlock Holmes Chapter One: A Smoking Gun | comic story | 22 | script: Leah Moore, John Reppion; pencils: Aaron Campbell; inks: Aaron Campbell; colors: Tony Aviña; letters: Simon Bowland | Sherlock Holmes |
| 4 | Sherlock Holmes | cover reprint (on interior page) | 1 | pencils: John Cassaday; inks: John Cassaday | Sherlock Holmes |
| 5 | The Trial of Sherlock Holmes Chapter Two: A Locked Room | comic story | 22 | script: Leah Moore, John Reppion; pencils: Aaron Campbell; inks: Aaron Campbell; colors: Tony Aviña; letters: Simon Bowland | Sherlock Holmes |
| 6 | Sherlock Holmes | cover reprint (on interior page) | 1 | pencils: John Cassaday; inks: John Cassaday | |
| 7 | The Trial of Sherlock Holmes Chapter Three: A Killer on the Loose | comic story | 22 | script: Leah Moore, John Reppion; pencils: Aaron Campbell; inks: Aaron Campbell; colors: Tony Aviña; letters: Simon Bowland | Sherlock Holmes |
| 8 | Sherlock Holmes | cover reprint (on interior page) | 1 | pencils: John Cassaday; inks: John Cassaday | Sherlock Holmes |
| 9 | The Trial of Sherlock Holmes Chapter Four: Brough to Justice | comic story | 22 | script: Leah Moore, John Reppion; pencils: Aaron Campbell; inks: Aaron Campbell; colors: Tony Aviña; letters: Simon Bowland | Sherlock Holmes |
| 10 | Sherlock Holmes | cover reprint (on interior page) | 1 | pencils: John Cassaday; inks: John Cassaday | Sherlock Holmes; Dr. Watson |
| 11 | The Trial of Sherlock Holmes Chapter Five: Endgame | comic story | 22 | script: Leah Moore, John Reppion; pencils: Aaron Campbell; inks: Aaron Campbell; colors: Tony Aviña; letters: Simon Bowland | Sherlock Holmes |
| 12 | Afterword: Sherlock Holmes in the Funny Papers | foreword, introduction, preface, afterword | 2 | script: Leslie S. Klinger | |
| 13 | From the Author | foreword, introduction, preface, afterword | 2 | script: Leah Moore | |
| 14 | Character Designs | illustration | 1 | pencils: Aaron Campbell; inks: Aaron Campbell | Sherlock Holmes |
| 15 | The Trial of Sherlock Holmes Part One: Smoking Gun | text article | 12 | script: Leah Moore, John Reppion; pencils: Aaron Campbell; inks: Aaron Campbell | |
| 16 | The Adventure of the Devil's Foot | text story | 20 | script: Sir Arthur Conan Doyle; pencils: Aaron Campbell; inks: Aaron Campbell | Sherlock Holmes; Dr. Watson |