| 0 | Who Needs You? | cover | 1 | pencils: Norman Mingo; inks: Norman Mingo; colors: Norman Mingo; letters: Norman Mingo | Alfred E. Neuman [as Uncle Sam] |
| 1 | Mad's Color Puzzle Page | cartoon | 1 | script: Al Jaffee; pencils: Bob Clarke; inks: Bob Clarke; colors: Bob Clarke | |
| 2 | Why Not Have the Next Issue Sent Directly to Your Home? | promo (ad from the publisher) | 0.67 | script: Nick Meglin; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 3 | A Mad Look at the Diseases of Our Sick Society | photo story | 3 | script: Max Brandel | |
| 4 | Familiar Affair | comic story | 4 | script: Stan Hart; pencils: Mort Drucker; inks: Mort Drucker | Brian Keith [as Uncle Bilge]; Sebastian Cabot [as Mr. Stench]; Kathy Garver [as Sassy]; Anissa Jones [as Boffy]; Johnny Whitaker [as Jokey] |
| 5 | A Mad Look at Hugh vs. Helen | text story | 1 | script: Ronnie Nathan; pencils: Jack Rickard; inks: Jack Rickard | Hugh Hefner; Helen Gurley Brown |
| 6 | Outside a Novelty Shop | comic story | 3 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 7 | Mad's 1968-'69 Football Low Lights | comic story | 4 | script: Al Jaffee; pencils: Jack Davis; inks: Jack Davis | |
| 8 | Drawn Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 9 | Spy vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 10 | If Comic Strips Covered the Burning Issues of the Day | comic story | 3 | script: Frank Ridgeway; pencils: Bob Clarke; inks: Bob Clarke | Superman; Dick Tracy; Pat Patton; Beetle Bailey; Sgt. Orville Snorkel; Capt. Scabbard; Snoopy; Mandrake the Magician; Lothar; Popeye; Olive Oyl; Wellington J. Wimpy; Archie Andrews; Jughead Jones |
| 11 | Mad's "Late Show" Cliche Movie Scripts: The "Opera" Movie | text story | 1 | script: Harry Purvis; pencils: Bruce Stark; inks: Bruce Stark | |
| 12 | A Mad Peek Behind the Scenes at an Airport | comic story | 2 | script: Larry Siegel; pencils: Jack Rickard; inks: Jack Rickard | |
| 13 | You're in Trouble...When They Smile | comic story | 3 | script: Stan Hart, Chris Hart; pencils: George Woodbridge; inks: George Woodbridge | Charles DeGaulle; Mao-tse Tung; Stokely Carmichael; George Wallace |
| 14 | In an Italian Restaurant | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 15 | The Mad Plan to Beautify America | illustration | 4 | script: Dick DeBartolo; pencils: Bob Clarke; inks: Bob Clarke | |
| 16 | The Lighter Side of American Tourists | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 17 | Spy vs. Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy |
| 18 | A Mad Look at...Frustration | comic story | 3 | script: Jack Kent; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 19 | Games People Play | text story | 1 | script: Ronnie Nathan; pencils: Bob Clarke; inks: Bob Clarke | |
| 20 | The Typical "Success Story" | comic story | 5 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | John Garfield [as Joey]; Lee J. Cobb [as Pop]; Shirley Booth [as Shirley]; Dustin Hoffman [as Ricky]; David Niven [as Dad]; Mia Farrow [as the Hippie Chick]; Candace Bergen [as Samantha] |
| 21 | Which Modern Artist Is Most Successfully Communicating with His Audience? | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |
| 22 | The Beat Generation | comic story | 1 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Sergio Aragonés | |