| 0 | Mad Is a Four-Letter Word | cover | 1 | | |
| 1 | Early One Morning in the Near Future | comic story | 1 | script: Sergio Aragonés; pencils: George Woodbridge; inks: George Woodbridge; colors: George Woodbridge | |
| 2 | - | table of contents | 1 | letters: typeset | |
| 3 | - | letters page | 2 | script: Jerry De Fuccio | |
| 4 | The Clods of '44 | comic story | 7 | script: Stan Hart; pencils: Mort Drucker; inks: Mort Drucker | Gary Grimes [as Wormy]; Jerry Houser [as Husky]; Oliver Conant [as Beanie]; Deborah Winters [as Jolly] |
| 5 | Drawn Out Dramas | cartoon | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 6 | One Fine Day on a Guided Tour of Mount Rushmore | comic story | 2 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 7 | A Mad Look at Two Grammar School Generations | comic story | 3 | script: Lou Silverstone; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 8 | The Lighter Side of Corruption | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 9 | One Fine Day During the Civil War | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 10 | Relevant Job Applications | text story | 2 | script: Dick DeBartolo, Donald K. Epstein | |
| 11 | A Mad Look at Karate | cartoon | 3 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 12 | Picket & Strike | comic story | 6 | script: Lou Silverstone; pencils: George Woodbridge; inks: George Woodbridge | |
| 13 | A Witch's Tale | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | |
| 14 | Graffiti Through History | cartoon | 3 | script: Paul Peter Porges; pencils: Bob Clarke; inks: Bob Clarke | |
| 15 | Interpreting the News | photo story | 1 | script: Gary Alexander | Walter Cronkite |
| 16 | Mad's Sure-Fire Sports Predictions | comic story | 2 | script: Paul Peter Porges; pencils: Jack Davis; inks: Jack Davis | |
| 17 | Malice in Wonderland, or Watergate - - Through the Looking Glass | comic story | 2 | script: Lou Silverstone; pencils: Bob Clarke; inks: Bob Clarke | Richard Nixon; Charles Colson; John Mitchell; John Dean; Ron Zieglar; H.R. Haldeman; John Erlichman; Jeb Magruder; Martha Mitchell; Ronald Reagan; Spiro Agnew |
| 18 | One Fine Day in the Life of Leonardo da Vinci | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 19 | Least Horizon | comic story | 6 | script: Arnie Kogen; pencils: Angelo Torres; inks: Angelo Torres | Peter Finch [as Richard Runaway]; Michael York [as George Runaway]; George Kennedy [as Sam Cornylines]; Liv Ullman [as Saccharine]; Bobby Van [as Hardy Harhar]; Sally Kellerman [as Silly Huge]; Olivia Hussey [as Mitsia]; John Gielgud [as Chong]; Charles Boyer [as the High Lama] |
| 20 | What Volatile System Is Now Heavily Fueled and Promises to Rocket to Unlimited Heights? | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |
| 21 | Can You Spot the Former Cancel Smoker? | illustration | 1 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | |