| 0 | - | cover | 1 | pencils: Jack Rickard; inks: Jack Rickard; colors: Jack Rickard | Alfred E. Neuman |
| 1 | Mad Super Special Fall 1980 | promo (ad from the publisher) | 1 | | |
| 2 | Departments | table of contents | 1 | pencils: various; inks: various; letters: typeset | |
| 3 | Letters Dept. | letters page | 1 | pencils: Marv Newton (photo); inks: Marv Newton (photo); letters: typeset | Ken Howard (photo) |
| 4 | Star Blecch, The (Gacck!) Motion Picture | comic story | 7 | script: Dick DeBartolo; pencils: Mort Drucker; inks: Mort Drucker | William Shatner [as Admiral Curt [Captain Curt]]; James Doohan [as Spotty]; Stephen Collins [as Drecker]; Persis Khambatta [as Lt. Ileer]; DeForest Kelly [as Doctor Becoy]; Leonard Nimoy [as Spook] |
| 5 | An Eye-Popping Scene on a Corner | comic story | 1 | script: Don Edwing; pencils: Don Edwing; inks: Don Edwing; letters: Don Edwing | |
| 6 | Election Year Jabberwocky | comic story | 2 | script: Frank Jacobs; pencils: Angelo Torres; inks: Angelo Torres | Alfred E. Neuman |
| 7 | Don Martin Looks at... The Lone Ranger | comic story | 4 | script: Don Martin; pencils: Don Martin; inks: Don Martin | The Lone Ranger, John Reid, Silver, Tonto |
| 8 | The Lighter Side of... Keeping in Touch | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 9 | The Big One That Got Away | comic story | 1 | script: Don Edwing; pencils: Don Edwing; inks: Don Edwing; letters: Don Edwing | |
| 10 | Mad's All-Inclusive Do-It-Yourself Energy Crisis Newspaper Story | text story | 2 | script: Frank Jacobs | |
| 11 | Mad's Plan to Make the Congressional TV Show More Entertaining | comic story | 4 | script: Lou Silverstone; pencils: Jack Davis; inks: Jack Davis | Senator Proxie; Senator Olden Lecherous; Fanny Foxylady; Howard Coolsell; Wink Porkbarrel; Congressman Frank; Senator Boondoggle |
| 12 | Mad Laws Second Edition | comic story | 2 | script: Frank Jacobs; pencils: Paul Coker; inks: Paul Coker | |
| 13 | A Mad Collection of Some Very Rare Famous Family Album Rejects | comic story | 3 | script: Paul Peter Porges; pencils: Harry North; inks: Harry North | John Wayne; Barbra Streisand; Jacques Cousteau; Idi Amin Dada; Arnold Schwartzenegger; Woody Allen; Kareem Abdul-Jabbar; Farrah-Fawcett Majors; Telly Savalas; Julia Child; Albert Einstein; Bert Lance; Ralph Nader; Henry Kissinger |
| 14 | A High School Yearbook for Average Clods | comic story | 6 | script: Lou Silverstone; pencils: George Woodbridge; inks: George Woodbridge | Millard Fillmore; Gus "Grumpy" Zucchini; Calvin Clone; Bernard Schlepp; Frederick Fribble; Mary Ann Hohum; Allen Porknoy; Wendell Weedy; Jennifer Puerile; Linda May Grits; Sybil Hoffelmeyer; Farrah Lipschitz; Brett Shmecklehoff; Harold Hersheybar; Glenda Glitch; John "Dink" Smith; Molly Finsternishe |
| 15 | An Al Jaffee Snappy Answers to Stupid Questions: Fishing Incident | comic story | 2 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |
| 16 | Bentson | comic story | 6 | script: Tom Koch; pencils: Angelo Torres; inks: Angelo Torres | Robert Guillaume [as Bentson]; Missy Gold [as Kutie]; Mickey Mouse (cameo); William F. Buckley (cameo); Inga Swenson [as Miss Krauseheimer]; James Noble [as the Governor]; Sheik of Rajput; Katherine Helmond [as Jessica Tate] (cameo); Robert Mandan [as Chester Tate] (cameo); Jimmy Baio [as Billy Tate |
| 17 | What New Way Are People Falling "Head Over Heels" These Days? | cartoon | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |
| 18 | Our Nation's Lowest Award... The Congressional Medal of Dishonor | illustration | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |
| 19 | Drawn-Out Dramas | comic story | 0 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; letters: Sergio Aragonés | |