| 0 | We Destroy the Matrix | cover | 1 | script: Ray Alma; pencils: Mark Fredrickson; inks: Mark Fredrickson; colors: Mark Fredrickson | Alfred E. Neuman |
| 1 | Departments | table of contents | 1 | pencils: various; inks: various; colors: various; letters: typeset | |
| 2 | - | letters page | 3 | pencils: various; inks: various; colors: various; letters: typeset | |
| 3 | Is Our World Really All That Different from the Matrix? | comic story | 3 | script: Greg Leitman; pencils: Tom Richmond; inks: Tom Richmond | |
| 4 | Mad Readers Fondly Remember Their Favorite Dysfunctional Family Thanksgiving Moments | comic story | 3 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell; letters: John Caldwell | |
| 5 | 2-Letter Video Labels MTV Should Use | photo story | 3 | script: Desmond Devlin | |
| 6 | More Pleasant Little Thoughts That Might Help You Sleep Better at Night | comic story | 2 | script: David Shayne; pencils: Ray Alma; inks: Ray Alma | |
| 7 | Monroe and... the Matrix | comic story | 4 | script: Anthony Barbieri; pencils: Bill Wray; inks: Bill Wray; letters: Bill Wray | |
| 8 | A Series of Uneventful Misfortunes: The Similar Sequel | comic story | 8 | script: Dave Croatto; pencils: Gary Hallgren; inks: Gary Hallgren | |
| 9 | Spy vs Spy | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper; colors: Peter Kuper | The Black Spy, The White Spy |
| 10 | Sure Signs That Your School Is Under-Funded | comic story | 3 | script: Jacob Lambert; pencils: Hermann Mejía; inks: Hermann Mejía | |
| 11 | Absolute, Latest, Up-to-the-Minute Pick-Up Lines | comic story | 2 | script: Mike Snider; pencils: Tom Bunk; inks: Tom Bunk | |
| 12 | The On-Screen/Off-Screen Videogame Sound Effects Comparison Guide | comic story | 3 | script: Russ Cooper; pencils: Scott Bricher, Kevin Pope; inks: Scott Bricher, Kevin Pope; colors: Scott Bricher | |
| 13 | A Mad Look at Bars | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 14 | An Urgent Warning for All Internet Users from AOL | text story | 1 | script: Dick DeBartolo | |
| 15 | Mad's Unreal Outtakes from the Matrix Revolutions | photo story | 3 | script: Greg Leitman | |
| 16 | Norigami the Ancient Japanese Art of Paper Unfolding | comic story | 1 | script: Danno Sullivan; letters: typeset | |
| 17 | If 24 Really Depicted What Life Would Be Like for America's First Black President | comic story | 2 | script: Mike Mikula; pencils: Timothy Shamey; inks: Timothy Shamey | |
| 18 | What Has Turned Out to Be This Year's Biggest Work of Fiction? | cartoon | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | George W. Bush |