| 0 | 50 Worst Things About Video Games | cover | 1 | pencils: Greg Horn; inks: Greg Horn | |
| 1 | The Fundalini Pages | comic story | 3 | script: various; pencils: various; inks: various; letters: typeset | 50 Cent; Tom Cruise; Katie Holmes; George Bush; Dave Chappelle |
| 2 | Mad's 50 Worst Things About Video Games | comic story | 8 | script: Kenny Byerly, Jacob Lambert, David Shayne; pencils: Peter Bagge, Scott Bricher, Hermann Mejía, Francis Mao; inks: Peter Bagge, Scott Bricher, Hermann Mejía, Francis Mao | |
| 3 | Spy vs Spy | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper; colors: Peter Kuper | |
| 4 | 12 Ways to Make Divorce Easier on Kids | comic story | 2 | script: Teresa Burns Parkhurst; pencils: Teresa Burns Parkhurst; inks: Teresa Burns Parkhurst | |
| 5 | A Mad Look at Pets | comic story | 3 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 6 | The Strip Club | comic story | 3 | script: Paul Gilligan, Rob Harrell, Mo Willems, Ted Rall; pencils: Paul Gilligan, Rob Harrell, Mo Willems, Ted Rall; inks: Paul Gilligan, Rob Harrell, Mo Willems, Ted Rall; letters: Paul Gilligan, Rob Harrell, Mo Willems, Ted Rall | |
| 7 | John Caldwell's Telltale Signs That the Street Gang You're Joining Ain't All That Tough | comic story | 2 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell; letters: John Caldwell | |
| 8 | What's in Your Living Will? | comic story | 1 | script: Teresa Burns Parkhurst; pencils: Tom Bunk; inks: Tom Bunk | Roz Slocumberg;Lady Musafah;Dom "The Meat" Cappicola;Bud Festerd;Denny Bohnar;Ace Wilcot;Butchie McTague;Mavis Crampanato;Betty Wright;Jessica Lerpit;Tito Bondi;Patty-Anne Smeltz |
| 9 | Pre-Movie Screens We'd Like to See | comic story | 2 | script: Jeff Kruse; pencils: Al Jaffee; inks: Al Jaffee | |
| 10 | The MAD World of Dating | comic story | 3 | script: Stan Sinberg; pencils: Marc Hempel; inks: Marc Hempel | |
| 11 | Monroe and… Summer School! | comic story | 4 | script: Anthony Barbieri; pencils: Bill Wray; inks: Bill Wray | |
| 12 | Go Fetch! | text article | 3 | | |
| 13 | Duke Bissell's Tales of Undisputed Interest | comic story | 1 | script: P. C. Vey; pencils: P. C. Vey; inks: P. C. Vey; letters: P. C. Vey | |
| 14 | What Celebrities Laugh At | comic story | 2 | pencils: Sam Sisco; inks: Sam Sisco | |
| 15 | What's the Hot New Way Many Are Getting Their Music? | cartoon | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |