| 0 | The 20 Dumbest People, Events and Things 2010 | cover | 1 | pencils: Mark Fredrickson; inks: Mark Fredrickson; colors: Mark Fredrickson | Alfred E. Neuman |
| 1 | Subscribe to MAD and Own a Piece of MAD History! | promo (ad from the publisher) | 1 | pencils: Norman Mingo; inks: Norman Mingo | Alfred E. Neuman |
| 2 | Departments | table of contents | 1 | pencils: various; inks: various; letters: typeset | Alfred E. Neuman; Glenn Beck; Snooki; Barack Obama; Lord Druckermort |
| 3 | Random Samplings of Reader Mail | letters page | 2.59 | script: John Ficarra, Steve Brown; pencils: Antonio Prohías; inks: Antonio Prohías; colors: Antonio Prohías | The Black Spy, Alfred E. Neuman, The White Spy |
| 4 | Statement of the Ownership, Management, Circulation, Etc. | statement of ownership | 0.16 | script: Dan DiDio | |
| 5 | - | credits, title page | 0.25 | letters: typeset | |
| 6 | On Sale Now Wherever Books Are Still Sold! | promo (ad from the publisher) | 1 | pencils: Sergio Aragonés; inks: Sergio Aragonés | Sergio Aragones |
| 7 | The Fundalini Pages | comic story | 4 | script: J. C. Duffy, Nate Fakes, P. C. Vey, Tom Cheney, Jeff Kruse, Darren Johnson; pencils: J. C. Duffy, Nate Fakes, P. C. Vey, Tom Cheney, Tom Bunk, Bob Staake; inks: J. C. Duffy, Nate Fakes, P. C. Vey, Tom Cheney, Tom Bunk, Bob Staake; letters: Nate Fakes, P. C. Vey, Tom Cheney, Eric Scott | Katy Perry; Conan O'Brien; Andy Richter; Barack Obama; Clarence Thomas; Virginia Thomas; Ernest Borgnine; Waldo; Donnie The Douche |
| 8 | Haunted by the Ghost of Christmas Presents? | promo (ad from the publisher) | 1 | pencils: George Woodbridge; inks: George Woodbridge | Alfred E. Neuman (as Jacob Marley); Ebenezer Scrooge |
| 9 | For All Your Spying Needs! | promo (ad from the publisher) | 1 | pencils: ? (photo); inks: ? (photo); colors: ? (photo); letters: typeset | Black Spy; White Spy |
| 10 | Harry Plodder and It's Dreadful What Follows | comic story | 6 | script: Desmond Devlin; pencils: Tom Richmond; inks: Tom Richmond | Lord Druckermort; Drano Malformed; Mr. Malformed; Mrs. Malformed; Alfred E. Neuman (cameo); Mickey Mouse (cameo); Harry Plodder; Herwhiny; Headcheese (owl); Wendy The Good Little Witch (cameo); Ironman (cameo); Bad-Eye Moody; Grisly Spacklebreath; Runt; Slobby; Dolores MMMBop; Frosty The Snowman (ca |
| 11 | Spy vs. Spy | comic story | 2 | script: Peter Kuper; pencils: Peter Kuper; inks: Peter Kuper | Black Spy; White Spy |
| 12 | The Strip Club | comic story | 3 | script: Jacob Lambert, Kit Lively, Scott Nickel, Jason Yungbluth, Feggo, Joey Alison Sayers; pencils: Jacob Lambert, Kit Lively, Scott Nickel, Jason Yungbluth, Feggo, Joey Alison Sayers; inks: Jacob Lambert, Kit Lively, Scott Nickel, Jason Yungbluth, Feggo, Joey Alison Sayers; letters: Jacob Lambert, Kit Lively, Scott Nickel, Jason Yungbluth, Joey Alison Sayers, Tom Bland | |
| 13 | The MAD 20 Dumbest 2010 | comic story | 25 | script: Anthony Barbieri, Barry Liebmann, Dick DeBartolo, Matt Lassen, Jeff Kruse, Desmond Devlin; pencils: Jack Syracuse, Sam Viviano, Scott Bricher, Drew Friedman, Hermann Mejía, Roberto Parada; inks: Jack Syracuse, Sam Viviano, Scott Bricher, Drew Friedman, Hermann Mejía, Roberto Parada; colors: Al Jaffee, Richard Williams, AP/Wide World, Siloto / Dreamstime.com, Martin Tanubrata / Dreamstime.com, Rafael Lagillo / Dreamstime.com | Barack Obama; Mel Gibson; Minions; Lindsay Lohan; Shirley Sherrod; Bill O'Reilly; Andrew Breitbart; Sean Hannity; Tom Vilsack; Ben Jealous; LeBron James; Jim Gray; The Situation; Pauly D; Snooki; Jenni "JWOWW"; Jay Leno; Conan O'Brien; Pope Benedict XVI; Steven Slater; Lady Gaga; Jennifer Aniston; H |
| 14 | Spy vs. Spy 50th Anniversary 2011 Calendar | illustration | 2 | pencils: Antonio Prohías; inks: Antonio Prohías | Black Spy; White Spy; Grey Spy |
| 15 | A MAD Look At Twins, Triplets & Beyond | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Tom Luth | |
| 16 | The Upsides to a Nationwide Bedbug Infestation | comic story | 2 | script: John Caldwell; pencils: John Caldwell; inks: John Caldwell | |
| 17 | The MAD Guide To Man Boobs Volume 2 | illustration | 1 | script: Ryan Pagelow; pencils: Drew Friedman; inks: Drew Friedman | |