| 0 | This Issue Will Make J.F.K. Mad | cover | 1 | pencils: Kelly Freas; inks: Kelly Freas; colors: Kelly Freas | Alfred E. Neuman |
| 1 | How To Find Things You Never Expected | illustration | 1 | pencils: Bob Clarke; inks: Bob Clarke | |
| 2 | Comedy Albums By Musical Artists | comic story | 5 | script: Arnie Kogen; pencils: Wally Wood; inks: Wally Wood | Lawrence Welk; Xavier Cugat; Abby Lane; Van Cliburn; Judy Garland; Leonard Bernstein |
| 3 | In the Psychiatrist's Office | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 4 | Modern Household Accidents | comic story | 3 | script: Jack Mendelsohn; pencils: Mort Drucker; inks: Mort Drucker | |
| 5 | Vengeance | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | |
| 6 | Celebrities' Wallets | comic story | 2 | script: Arnie Kogen; pencils: George Woodbridge; inks: George Woodbridge | Bobby Darin |
| 7 | The Lighter Side of the Television Set | comic story | 3 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 8 | At the Dentist | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 9 | Mad Visits Joe LeVenal | comic story | 4 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | Joe LeVenal |
| 10 | Little Known Medical Crusades | comic story | 4 | script: Sy Reit; pencils: Bob Clarke; inks: Bob Clarke | Jerry Lewis; Yul Brynner |
| 11 | A Mad Look at Nature | comic story | 2 | script: Dean Norman; pencils: Dave Berg; inks: Dave Berg | |
| 12 | The Little League Hall of Fame | comic story | 3 | script: Tom Koch; pencils: Joe Orlando; inks: Joe Orlando | |
| 13 | More Than Meets the Eye | comic story | 2 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | |
| 14 | The Mad Mythology Primer | comic story | 3 | script: Walter Farley; pencils: George Woodbridge; inks: George Woodbridge | |
| 15 | Future Telephone Triumphs | comic story | 3 | script: Al Jaffee; pencils: Bob Clarke; inks: Bob Clarke | |
| 16 | Scenes We'd Like to See | comic story | 1 | pencils: Joe Orlando; inks: Joe Orlando | |
| 17 | Practical Scout Handbook | comic story | 5 | script: Larry Siegel; pencils: Jack Rickard; inks: Jack Rickard | |
| 18 | The Biology Professor | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 19 | The Best Friend Your Dentist Ever Had | illustration | 1 | pencils: Bob Clarke; inks: Bob Clarke; colors: Bob Clarke | |