| 0 | Special 10th Anniversary Issue | cover | 1 | pencils: Kelly Freas; inks: Kelly Freas; colors: Kelly Freas | Alfred E. Neuman |
| 1 | Memo | illustration | 1 | letters: typeset | |
| 2 | Alfred's Poor Almanac | comic story | 1 | script: Frank Jacobs | |
| 3 | C-Men in Action | comic story | 4 | script: Earle Doud; pencils: Mort Drucker; inks: Mort Drucker | Caroline Kennedy; John Kennedy; Jacqueline Kennedy; Frank Sinatra; Dean Martin; Sammy Davis Jr.; Shirley MacLaine; Peter Lawford; Dennis the Menace |
| 4 | A Fisherman and His Wife | comic story | 2 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 5 | Friend of the Family | photo story | 1 | letters: typeset | |
| 6 | Celebrities' Wallets | comic story | 2 | script: Arnie Kogen; pencils: Jack Rickard; inks: Jack Rickard | |
| 7 | The Lighter Side of Smoking | comic story | 4 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 8 | Mother's Day Cards For Substitute Mothers | comic story | 2 | script: Phil Hahn; pencils: George Woodbridge; inks: George Woodbridge | |
| 9 | Mad Visits a Charity Organization Meeting | comic story | 3 | script: Larry Siegel; pencils: Joe Orlando; inks: Joe Orlando | |
| 10 | Spy Vs Spy | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy, The White Spy |
| 11 | A Mad Guide to Party Conversation | comic story | 2 | pencils: Jack Rickard; inks: Jack Rickard | |
| 12 | If Comic Strip Characters Were As Old As Their Strips | comic story | 4 | script: Earle Doud; pencils: Wally Wood; inks: Wally Wood | Superman; Dick Tracy; Junior; Popeye; Bluto; Sweetpea; J. Wellington Wimpy; Fearless Fosdick; Li'l Abner; Daisy Mae; Mandrake the Magician; Lothar; Narda; Tarzan; Jane Porter; Henry; Dennis Mitchell |
| 13 | Mad Mother's Day Gift Suggestions | comic story | 2 | script: Tom Koch; pencils: Bob Clarke; inks: Bob Clarke | |
| 14 | Spy Vs. Spy, Part 2 | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy, The White Spy |
| 15 | A Typical Old Time Prison Movie/A Typical Prison Movie of the Future | comic story | 4 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | James Cagney; J.D. Cannon; George Raft; Edward G. Robinson; Forrest Tucker; Peter Lorre; Pat O'Brien |
| 16 | On the Elevator | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 17 | A Mad Look at the Eating Habits of Animals | comic story | 2 | script: Dean Norman; pencils: Wally Wood; inks: Wally Wood | |
| 18 | Scenes We'd Like to See | comic story | 1 | script: Don Edwing; pencils: George Woodbridge; inks: George Woodbridge | |
| 19 | A Mad Guide to "Do-It-Yourself" TV Repairs | comic story | 7 | script: Al Jaffee; pencils: Bob Clarke; inks: Bob Clarke | |
| 20 | The Salesman | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 21 | World's Only Dog Food That Regulates Your Doggy | illustration | 1 | pencils: Kelly Freas; inks: Kelly Freas; colors: Kelly Freas | |