| 0 | - | cover | 1 | pencils: Tom Richmond; inks: Tom Richmond; colors: Tom Richmond | |
| 1 | - | table of contents | 2 | script: Frank Jacobs; pencils: Bob Clarke, Norman Mingo; inks: Bob Clarke, Norman Mingo | |
| 2 | A Mad Look at Hospitals | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Tom Luth; letters: Sergio Aragonés | |
| 3 | Mad's Practical Joke Catalogue for Doctors | comic story | 2 | script: Beppe Sabatini; pencils: Al Jaffee; inks: Al Jaffee | |
| 4 | Schlubs | comic story | 5 | script: Charlie Kadau; pencils: Tom Richmond; inks: Tom Richmond | Zach Braff [as Dr. O.D.]; Ken Jenkins [as Dr. Throb Hellshow]; John C. McGinley [as Dr. Pill Box]; Judy Reyes [as Nurse Carlot]; Donald Faison [as Priss Jerk]; Sarah Chalke [as Dr. Smelliot Bleed]; Neil Flynn [as the Janitor]; Doc (cameo); Bugs Bunny (cameo); Dick Cheney (cameo); Noah Wylie (cameo); |
| 5 | This Issue's Proposed Mad Medals... to Be Presented to Deserving Doctors | comic story | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |
| 6 | - | comic story | 1 | script: Antonio Prohías; pencils: Antonio Prohías; inks: Antonio Prohías | The Black Spy; The White Spy; The Gray Spy |
| 7 | Great Moments in Medicine | comic story | 1 | pencils: Al Jaffee; inks: Al Jaffee | |
| 8 | The Bloodcurdling Blue-Cross Brouhaha | comic story | 1 | script: Duck Edwing; pencils: Don Edwing; inks: Don Edwing | |
| 9 | Dorky Housecall, M.D. | comic story | 5 | script: Dick DeBartolo; pencils: Angelo Torres; inks: Angelo Torres | Neil Patrick Harris [as Dorky Housecall, M.D.] |
| 10 | In the Doctor's Office | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 11 | Health Chairs | comic story | 2 | pencils: Bob Clarke; inks: Bob Clarke | |
| 12 | Get a New Psychiatrist If... | comic story | 3 | script: Desmond Devlin, Butch D'Ambrosio; pencils: Al Jaffee; inks: Al Jaffee | |
| 13 | Paging Dr. Jaffee... Dr. Al Jaffee | cover reprint (on interior page) | 1 | pencils: Sam Viviano, Al Jaffee; inks: Sam Viviano | |
| 14 | A Mad Look at Alternative Medicine | comic story | 4 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés; colors: Tom Luth; letters: Sergio Aragonés | |
| 15 | One Fine Day at the Chiropractors’ Convention | comic story | 2 | script: Duck Edwing; pencils: Tom Bunk; inks: Tom Bunk | |
| 16 | The Lighter Side of Minor Ailments | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 17 | One Balmy Morning in the Operation Room | comic story | 1 | script: Don Edwing; pencils: Don Martin; inks: Don Martin; colors: Don Martin | |
| 18 | A Mad Peek Behind the Scenes at a Hospital | comic story | 2 | script: Larry Siegel; pencils: Al Jaffee; inks: Al Jaffee | |
| 19 | What Have We Got Against Colds? | illustration | 1 | letters: typeset | |
| 20 | This Issue's Proposed Mad Medals... to be Presented to Deserving Medical Workers | comic story | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee | |
| 21 | Little-Known and Rarely Diagnosed Mad Ailments Contracted at ...Hospitals | comic story | 2 | script: Don Edwing; pencils: Don Edwing; inks: Don Edwing | |
| 22 | Groin's Monotony | comic story | 5 | script: Arnie Kogen; pencils: Tom Richmond; inks: Tom Richmond; colors: Tom Richmond | |
| 23 | Mad's Medical Mother Goose | comic story | 3 | script: Larry Siegel; pencils: Al Jaffee; inks: Al Jaffee | |
| 24 | Side Effects of Drug Side Effects | cartoon | 0.4 | pencils: Paul Coker; inks: Paul Coker | |
| 25 | Medical Shows Coming to TLC | comic story | 0.4 | pencils: Evan Dorkin; inks: Evan Dorkin; colors: Sarah Dyer | Barack Obama; Lady Gaga; Twisted Toaster; Sarah Palin; Geico Gecko; Flo; Dennis Haysbert; Jake Sully; Mark McGwire; Billy Mays; Glenn Beck; Garfield; Conan O'Brien; Jay Leno |
| 26 | What Food-Borne Illness are Millions of People Suffering From? | illustration | 1 | script: Johnny Sampson; pencils: Johnny Sampson; inks: Johnny Sampson; colors: Johnny Sampson | |
| 27 | Great Moments in Medicine | comic story | 1 | pencils: Kelly Freas; inks: Kelly Freas; colors: Kelly Freas | |