| 0 | Mad Super Special | cover | 1 | pencils: Bill Elder, Wally Wood, Jack Davis | Shermlock Shomes; Dr. Whatsit; Marlon Branflakes; Lone Stranger; Bottleneck; Starchie |
| 1 | The Nostalgic Mad No. 4 | cover reprint (on interior page) | 1 | pencils: Harvey Kurtzman; inks: Harvey Kurtzman; letters: Harvey Kurtzman | Shermlock Shomes; Dr. Whatsit |
| 2 | Shermlock Shomes! | comic story | 8 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Dr. Whatsit; Shermlock Shomes |
| 3 | Wild 1/2 | comic story | 8 | script: Harvey Kurtzman; pencils: Wally Wood; inks: Wally Wood; colors: Marie Severin | Marlon Branflakes |
| 4 | Lone Stranger Rides Again! | comic story | 7 | script: Harvey Kurtzman; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin | Lone Stranger; Pronto |
| 5 | William M. Gaines (Alias Melvin) | text article | 1 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder | William M. Gaines |
| 6 | Starchie | comic story | 8 | script: Harvey Kurtzman; pencils: Bill Elder; inks: Bill Elder; colors: Marie Severin | Starchie; Bottleneck; Mr. Weathernot; Salonica; Biddy; Wedgie Van Smelt |
| 7 | Tales Calculated to Drive You Mad | cover reprint (on interior page) | 1 | | |
| 8 | Table of Contents | foreword, introduction, preface, afterword | 1 | pencils: Bill Elder, Wally Wood, Jack Davis | Dr. Whatsit; Shermlock Shomes; Bottleneck; Starchie; Marlon Branflakes; Lone Stranger |
| 9 | Mad Final Episodes of Some Long-Running TV Shows | comic story | 6 | script: Lou Silverstone; pencils: Angelo Torres; inks: Angelo Torres | Major Frank Burns; Major Hoolihan; Cpl. Max Klinger; Radar O’Reilly; Columbo; Matt Dillon; Festus; Doc; Kwai Chang Caine; Archie Bunker; Edith Bunker; Mike Stivic; Gloria Stivic; George Jefferson |
| 10 | How Today's "Special Interest" Pressure Groups Would Rewrite the Constitution | text article | 2 | script: William Garvin | |
| 11 | A Portfolio of Mad Good News-Bad News Photo Silhouettes | photo story | 4 | script: Arnoldo Franchioni; pencils: Arnoldo Franchioni | Marlon Brando; Beatles; Charlie Chaplin; Jerry Lewis |
| 12 | The Marvelous Mad De-Coding Machine | comic story | 3 | script: Stan Hart; pencils: Jack Rickard; inks: Jack Rickard | |
| 13 | Spell It Like It Is | text story | 1 | script: Norman Miller | |
| 14 | Shmoe | comic story | 6 | script: Larry Siegel; pencils: Mort Drucker; inks: Mort Drucker | Melistless Compost; Hank; Bull Compost; Shmoe; Spiro Agnew (cameo) |
| 15 | Recruiting Posters Through History | comic story | 3 | script: Paul Peter Porges; pencils: George Woodbridge; inks: George Woodbridge | |
| 16 | The Very First Musical Instrument | comic story | 2 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 17 | What They Say ... and What It Really Means | comic story | 3 | script: George Hart; pencils: Bob Clarke; inks: Bob Clarke | |
| 18 | Answers to Children's Letters--From Santa | photo story | 2 | script: Dick DeBartolo, Donald K. Epstein; pencils: UPI; inks: UPI | |
| 19 | The Lighter Side of ... Love | comic story | 4 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 20 | Condolence Cards for Business and Professional Tragedies | comic story | 3 | script: Frank Jacobs; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 21 | One Hot Summer Morning | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 22 | A Mad Look at Pet Owners | comic story | 2 | script: Stan Hart; pencils: Bob Clarke; inks: Bob Clarke | |
| 23 | Meet Sudhir Dar | comic story | 3 | script: Sudhir Dar; pencils: Sudhir Dar; inks: Sudhir Dar | |
| 24 | Mad's Reality Street | comic story | 6 | script: Dick DeBartolo; pencils: Jack Davis; inks: Jack Davis | Dirty Bird; Curt; Ornery; Cake Monster; Scary |
| 25 | Modern Art | photo story | 1 | script: Max Brandel; pencils: Irving Schild; inks: Irving Schild | |
| 26 | The Psychology of Snoring | comic story | 2 | script: Frank Jacobs | |
| 27 | One Morning on Main Street | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 28 | Excuses, Excuses! | comic story | 3 | script: Dick DeBartolo, Donald K. Epstein; pencils: George Woodbridge; inks: George Woodbridge | |
| 29 | A Collection of Mad X-Rayvings | cartoon | 2 | script: Don Edwing; pencils: Bob Clarke; inks: Bob Clarke | |
| 30 | The Lighter Side of ... Living Space | comic story | 5 | script: Dave Berg; pencils: Dave Berg; inks: Dave Berg | |
| 31 | Future Shock | comic story | 2 | script: Sergio Aragonés; pencils: Sergio Aragonés; inks: Sergio Aragonés | |
| 32 | The Mad Orthodontia Primer | comic story | 3 | script: Larry Siegel; pencils: Paul Coker Jr.; inks: Paul Coker Jr. | |
| 33 | Spy vs. Spy | comic story | 1 | script: Anthony Prohías; pencils: Anthony Prohías; inks: Anthony Prohías | The Black Spy; The White Spy |
| 34 | The New Army | comic story | 4 | script: Frank Jacobs; pencils: Jack Davis; inks: Jack Davis | |
| 35 | Congressional Off-the-Record | photo story | 5 | script: Lou Silverstone; pencils: Irving Schild; inks: Irving Schild | |
| 36 | A Mad Peek Behind the Scenes at a Recording Studio | comic story | 2 | script: Earle Doud; pencils: Jack Davis; inks: Jack Davis | |
| 37 | If the Characters in "Peanuts" Aged Like Ordinary People | comic story | 4 | script: Frank Jacobs; pencils: Bob Clarke; inks: Bob Clarke | Charlie Brown; Schroeder; Lucy Van Pelt; Pigpen; Linus Van Pelt; Violet; Snoopy; Woodstock |
| 38 | A Mad Look at Water Beds | comic story | 2 | script: Paul Peter Porges; pencils: Paul Peter Porges; inks: Paul Peter Porges | |
| 39 | An Italian Robin Catching a Worm | comic story | 1 | script: Don Martin; pencils: Don Martin; inks: Don Martin | |
| 40 | The Trauma of '42 | comic story | 6 | script: Stan Hart; pencils: Mort Drucker; inks: Mort Drucker | Wormy; Mrs. Pushover |
| 41 | What Is Fast Becoming the Only Place to See Rare Vanishing Animal Species? | cartoon | 1 | script: Al Jaffee; pencils: Al Jaffee; inks: Al Jaffee; colors: Al Jaffee | |
| 42 | The Four Horsemen of the Metropolis | illustration | 1 | script: Frank Jacobs; pencils: Jack Thurston; inks: Jack Thurston | Drugs; Graft; Pollution; Slums |