| 0 | Cover A | cover | 1 | pencils: John K. Snyder III; inks: John K. Snyder III; colors: Jason Wright | |
| 1 | Infestation Update | recap | 1 | pencils: John K. Snyder III, Gabriel Rodriguez, Giovanni Timpano, Alejandro Germánico; inks: John K. Snyder III, Gabriel Rodriguez, Giovanni Timpano; colors: Jason Wright, J. Brown | |
| 2 | - | comic story | 22 | script: Mike Raicht; pencils: Giovanni Timpano; inks: Giovanni Timpano; colors: J. Brown; letters: Chris Mowry | G.I. Joe [Dolphin; Hound (death); Psyche Out [Kenneth D. Rich]]; Cobra [Baroness; Covert Eel Raid Team 1; Dr. Jacob Mitchell; Dr. Elizabeth Zych; Eel 3 (death); Interrogator; Vipers] (villains); Raptor |
| 3 | Cover Preview - G.I. Joe: Infestation #2 | promo (ad from the publisher) | 1 | pencils: Giovanni Timpano; inks: Giovanni Timpano; colors: J. Brown | Psyche Out [Kenneth D. Rich]; Baroness |
| 4 | Sneak Peak: Tranformers: Infestation #1 | promo (ad from the publisher) | 2 | script: Dan Abnett, Andy Lanning; pencils: Nick Roche; inks: Nick Roche; colors: Joana Lafuente; letters: Robbie Robbins; editing: Andy Schmidt, Bobby Curnow | Galvatron; Optimus Prime; Bumblebee; Kup; Prowl; Wheeljack; Major Spike Witwicky |
| 5 | Sneak Peek: Star Trek: Infestation #1 | promo (ad from the publisher) | 2 | script: Scott Tipton, David Tipton; pencils: Casey Maloney, Gary Erskine; inks: Gary Erskine; colors: Luis Antonio Delgado; letters: Chris Mowry; editing: Tom Waltz, Bobby Curnow | Admiral James T. Kirk; Mr. Spock; Bones [Dr. Leonard McCoy]; Barnes; Emigh; Padilla |
| 6 | Sneak Peek: Ghostbusters: Infestation #1 | promo (ad from the publisher) | 2 | script: Erik Burnham; pencils: Kyle Hotz; inks: Kyle Hotz; colors: Dan Brown; letters: Chris Mowry; editing: Tom Waltz, Bobby Curnow | Dr. Egon Spengler; Winston Zeddemore |
| 7 | Infestation Checklist | promo (ad from the publisher) | 1 | | |