| 0 | - | cover | 1 | pencils: Phil Moy; inks: Phil Moy; colors: Jason Lewis | |
| 1 | - | blank page(s) | 1 | | |
| 2 | The Powerpuff Girls Classics Volume 1 | credits, title page | 1 | letters: typeset | |
| 3 | - | credits, title page | 1 | letters: typeset | |
| 4 | Go, Girls, Go! | cover reprint (on interior page) | 1 | pencils: Craig McCracken; inks: Mike DeCarlo | |
| 5 | Snack in the Face | comic story | 22 | script: Craig McCracken, Genndy Tartakovsky; pencils: Craig McCracken; inks: Mike DeCarlo; colors: Dave Tanguay, Harvey Richards; letters: Phil Felix | |
| 6 | - | cover reprint (on interior page) | 1 | pencils: Craig McCracken; inks: Jeff Albrecht; colors: Dave Tanguay; letters: Todd Klein | |
| 7 | Black and Blue Period | comic story | 22 | script: Craig McCracken; pencils: Paul Rudish, Cindy Morrow; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Phil Felix | Blossom, Bubbles, Buttercup |
| 8 | Go, Squirrel, Go! | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; letters: Todd Klein | Blossom; Buttercup; Bubbles; Twitchy |
| 9 | Squirrelly Burly | comic story | 22 | script: Jennifer Moore, Sean Carolan; pencils: Phil Moy; inks: Phil Moy; colors: Dave Tanguay; letters: Janice Chiang | Blossom; Buttercup; Bubbles; Twitchy; Mojo Jojo; The Mayor; Professor Utonium; Sara Bellum (cameo) |
| 10 | Where Did the Love Go? | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; letters: Todd Klein | Blossom; Buttercup; Bubbles |
| 11 | Buttercup's Boyfriend | comic story | 22 | script: Abby Denson; pencils: Dan Fraga; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Ryan Cline | Buttercup; Blossom; Bubbles; Miss Keane; Tommy; HIM |
| 12 | - | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; letters: Todd Klein | Buttercup; Blossom; Bubbles; Professor Utonium; Mayor; Miss Keane |
| 13 | Power Play | comic story | 22 | script: Sean Carolan, Jennifer Moore; pencils: Phil Moy; inks: Phil Moy; colors: Dave Tanguay; letters: Ryan Cline | Buttercup; Bubbles; Blossom; Professor Utonium; Mayor; Sara Bellum; Miss Keane |
| 14 | Bigger Than Ever! | cover reprint (on interior page) | 1 | pencils: Phil Moy; inks: Phil Moy; letters: Todd Klein | Blossom; Bubbles; Buttercup |
| 15 | Video Maim | comic story | 22 | script: Abby Denson; pencils: Stephanie Gladden; inks: Mike DeCarlo; colors: Dave Tanguay; letters: Ryan Cline | Buttercup; Bubbles; Blossom; Professor Utonium; Mayor; Sara Bellum; HIM |
| 16 | - | blank page(s) | 1 | | |
| 17 | - | illustration | 1 | letters: typeset | |