| 0 | - | cover | 1 | pencils: Mark Bagley; inks: Randy Emberlin | Spider-Man [Peter Parker] |
| 1 | Epic Collection | promo (ad from the publisher) | 1 | letters: typeset | |
| 2 | - | credits, title page | 2 | letters: typeset | |
| 3 | - | table of contents | 1 | letters: typeset | |
| 4 | - | cover reprint (on interior page) | 2 | pencils: Michael Bair; inks: Michael Bair; colors: Michael Bair | |
| 5 | - | credits, title page | 1 | letters: typeset | |
| 6 | The Way to Dusty Death | comic story | 62 | script: Roy Thomas, Gerry Conway; pencils: Michael Bair; inks: Mark Beachum, Mark Texeira, Michael Bair; colors: Bob Sharen; letters: Joe Rosen, Rick Parker | |
| 7 | - | credits, title page | 1 | letters: typeset | |
| 8 | The Trial of Venom | cover reprint (on interior page) | 1 | pencils: Jim Craig; inks: Dan Day | Venom [Eddie Brock]; Spider-Man [Peter Parker]; Daredevil [Matthew Murdock] |
| 9 | The Trial of Venom | comic story | 22 | script: Peter David; pencils: Jim Craig; inks: Dan Day, David Day; colors: Tom Smith; letters: Ken Lopez | Spider-Man [Peter Parker]; Daredevil [Matthew Murdock]; Ms. Brewster; Brent Nagle; Moonstone [Karla Sofen] (cameo); Venom [Eddie Brock] (villain) |
| 10 | Spider-Man Special Edition: the Trial of Venom Bound-in Poster | illustration | 1 | pencils: Jim Craig; inks: Nelson; colors: Chris Sotomayor | |
| 11 | Invasion of the Spider-Slayers, Part One of Six! | cover reprint (on interior page) | 1 | pencils: Bags; inks: Randy Emberlin | Spider-Man [Peter Parker]; Spider-Slayer robot; Mary Parker; Richard Parker |
| 12 | Invasion of the Spider-Slayers, Part One of Six: On Razored Wings | comic story | 16 | script: David Michelinie; pencils: Mark Bagley; inks: Randy Emberlin; colors: Bob Sharen; letters: Rick Parker | Spider-Man [Peter Parker]; Mary Jane Watson-Parker; Richard Parker; Mary Parker; Aunt May Parker; J. Jonah Jameson; Ben Urich; Felicia Hardy [Black Cat]; Agent Charlie Shaddock; Spider-Slayer [Alistair Alphonso Smythe] (villain); Spider-Slayer robot (villain) |
| 13 | Cashing In | comic story | 6 | script: J. M. DeMatteis; pencils: Aaron Lopresti; inks: Aaron Lopresti; colors: Bob Sharen; letters: Steve Dutro | Peter Parker [Spider-Man]; J. Jonah Jameson; Robbie Robertson |
| 14 | Invasion of the Spider-Slayers Part Two of Six! | cover reprint (on interior page) | 1 | pencils: Bags; inks: Randy Emberlin | Spider-Man [Peter Parker]; Electro; Spider-Slayer Robot |
| 15 | Invasion of the Spider-Slayers Part 2: Electric Doom | comic story | 16 | script: David Michelinie; pencils: Mark Bagley; inks: Randy Emberlin; colors: Bob Sharen; letters: Dave Sharpe | Spider-Man [Peter Parker]; Mary Jane Parker; Flash Thompson; Felicia Hardy [Black Cat]; Richard Parker; Mary Parker; Electro (villain); Spider-Slayer (villain); Spider-Slayer Robot (villain); Tinkerer (cameo) |
| 16 | More Bad News | comic story | 6 | script: J. M. DeMatteis; pencils: Tod Smith; inks: Don Hudson; colors: Bob Sharen; letters: Steve Dutro | Harry Osborn [Green Goblin]; Guardsmen; Liz Osborn |
| 17 | Invasion of the Spider-Slayers, Part Three of Six! | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Randy Emberlin | Spider-Man [Peter Parker]; Black Cat [Felicia Hardy]; Scorpion [MacDonald Gargan] |
| 18 | Invasion of the Spider-Slayers, Part Three of Six: Life Stings! | comic story | 16 | script: David Michelinie; pencils: Mark Bagley; inks: Randy Emberlin; colors: Bob Sharen; letters: David Sharpe | Spider-Man [Peter Parker]; Mary Jane Watson-Parker; Richard Parker; Mary Parker; Felicia Hardy [Black Cat]; Agent Charlie Shaddock; Scorpion [Mac Gargan]; Tinkerer [Phineas Mason]; Amoeboid robot |
| 19 | The Web | comic story | 6 | script: J. M. DeMatteis; pencils: Aaron Lopresti; inks: Aaron Lopresti; colors: Bob Sharen; letters: Joe Rosen | Aunt May Parker; Uncle Ben Parker (flashback); Richard Parker (flashback); Mary Parker (flashback); Peter Parker [Spider-Man] (flashback); Mary Jane Watson-Parker (flashback) |
| 20 | Invasion of the Spider-Slayers Part Four of Six! | cover reprint (on interior page) | 1 | pencils: Bags; inks: Randy Emberlin | Spider-Man [Peter Parker]; Black Cat [Felicia Hardy]; Spider-Slayer |
| 21 | Invasion of the Spider-Slayers Part 4: One Clue Over the Cuckoo's Nest | comic story | 16 | script: David Michelinie; pencils: Mark Bagley; inks: Randy Emberlin; colors: Bob Sharen; letters: Richard Starkings | Spider-Man [Peter Parker]; Black Cat [Felicia Hardy] (new costume); Mary Jane Parker; Richard Parker; Mary Parker; Spider-Slayer Robot (villain) |
| 22 | Strained Relations | comic story | 6 | script: Al Milgrom; pencils: Aaron Lopresti; inks: Don Hudson; colors: Marie Javins; letters: Jon Babcock | Mary Jane Parker |
| 23 | Invasion of the Spider-Slayers Part Five of Six! | cover reprint (on interior page) | 1 | pencils: Bags; inks: Randy Emberlin | Spider-Man [Peter Parker]; Black Cat [Felicia Hardy]; Spider-Slayer robots |
| 24 | Invasion of the Spider-Slayers Part 5 Arachnophobia Too! | comic story | 17 | script: David Michelinie; pencils: Mark Bagley; inks: Randy Emberlin; colors: Bob Sharen; letters: Richard Starkings | Spider-Man [Peter Parker]; Aunt May Parker; Richard Parker; Mary Parker; Felicia Hardy [Black Cat]; Agent Charlie Shaddock; Spider-Slayer [Alistair Smythe] (villain); Spider-Slayer robot (villain) |
| 25 | Punch... Counter-Punch | comic story | 6 | script: Al Milgrom; pencils: Aaron Lopresti; inks: Mark Stegbauer; colors: Bob Sharen; letters: Steve Dutro | Peter Parker [Spider-Man]; Flash Thompson |
| 26 | Invasion of the Spider-Slayers Conclusion! | cover reprint (on interior page) | 1 | pencils: Bags; inks: Randy Emberlin | Spider-Man [Peter Parker] |
| 27 | Invasion of the Spider-Slayers Part 6: The Bedlam Perspective | comic story | 16 | script: David Michelinie; pencils: Mark Bagley; inks: Randy Emberlin; colors: Bob Sharen; letters: Richard Starkings | Spider-Man [Peter Parker]; Mary Jane Parker; Aunt May Parker; Richard Parker; Mary Parker; Ultimate Spider-Slayer [Alistair Smythe] (villain) |
| 28 | The Getaway Scream! | comic story | 6 | script: David Michelinie; pencils: Tod Smith; inks: Tod Smith; colors: Bob Sharen; letters: Rich S. | Venom [Eddie Brock]; Peter Parker [Spider-Man] (cameo); Mary Parker (cameo); Richard Parker (cameo) |
| 29 | Venom Attacks! | cover reprint (on interior page) | 1 | pencils: Bags; inks: Randy Emberlin | Spider-Man [Peter Parker]; Venom [Eddie Brock]; Richard Parker; Mary Parker |
| 30 | Murder on Parade | comic story | 22 | script: David Michelinie; pencils: Mark Bagley; inks: Randy Emberlin; colors: Bob Sharen; letters: Steve Dutro | Spider-Man [Peter Parker]; Mary Jane Parker; Aunt May Parker; Ben Urich; J. Jonah Jameson; Richard Parker; Mary Parker; Venom [Eddie Brock] (villain) |
| 31 | Spidey vs. Venom: The Final Confrontation | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Randy Emberlin | Spider-Man [Peter Parker]; Venom [Eddie Brock] |
| 32 | - | credits, title page | 1 | letters: typeset | |
| 33 | The Bride of Venom | comic story | 28 | script: David Michelinie; pencils: Mark Bagley; inks: Randy Emberlin; colors: Bob Sharen; letters: Richard Starkings, Rick Parker | Spider-Man [Peter Parker]; Richard Parker; Mary Parker; Silver Sable; Wild Pack; Battlestar; J. Jonah Jameson; Anne Weying (Venom's Ex-Wife); Lance Bannon; Mary Jane Parker; Venom [Eddie Brock] (villain) |
| 34 | True Friends! | comic story | 7 | script: Tom DeFalco; pencils: Pat Olliffe; inks: Mark McKenna; colors: Renee Witterstaetter; letters: Dave Sharpe | Spider-Man [Peter Parker]; Fantastic Four [Human Torch [Johnny Storm]; Thing; Mr. Fantastic; Invisible Woman]; Silver Sable; Wild Pack; Battlestar; Dr. Octopus (villain); Sandman (villain); Venom [Eddie Brock] (villain) |
| 35 | The Monster Within | comic story | 8 | script: Eric Fein; pencils: Dan Panosian; inks: Dan Panosian; colors: Tom Smith; letters: Joe Rosen | John Jameson; J. Jonah Jameson; Man-Wolf; Spider-Man [Peter Parker] (cameo) |
| 36 | Echoes... | comic story | 8 | script: Terry Kavanagh; pencils: Aaron Lopresti; inks: Don Hudson; colors: Renee Witterstaetter; letters: Jon Babcock | Chameleon; Spider-Man [Chameleon]; Kraven [Chameleon] (villain) |
| 37 | It's a Bad Day to Be Spider-Man! | cover reprint (on interior page) | 1 | pencils: Bags; inks: Randy Emberlin | Spider-Man [Peter Parker]; Cardiac; Styx; Stone |
| 38 | Guilt by Association | comic story | 22 | script: David Michelinie, Steven Grant; pencils: Jeff Johnson; inks: Dan Panosian, Al Milgrom; colors: Bob Sharen, Kevin Tinsley; letters: Rick Parker | Spider-Man [Peter Parker]; Cardiac; Styx; Stone; William Gant; Mary Jane Parker; Richard Parker; Mary Parker; Kevin |
| 39 | The Fury of Cardiac! | cover reprint (on interior page) | 1 | pencils: Bags; inks: Randy Emberlin | Spider-Man [Peter Parker]; Cardiac |
| 40 | Dust to Dust | comic story | 22 | script: David Michelinie, Steven Grant; pencils: Jeff Johnson; inks: Randy Emberlin; colors: Bob Sharen; letters: Rick Parker | Spider-Man [Peter Parker]; Cardiac; Styx; Stone; J. Jonah Jameson; Richard Parker; Mary Parker; Robbie Robertson |
| 41 | Annex Just Hit Town! | cover reprint (on interior page) | 1 | pencils: Tom Lyle; inks: Tom Lyle | Annex |
| 42 | Table of Contents | table of contents | 1 | pencils: Tom Lyle; inks: Scott Hanna | Spider-Man [Peter Parker] |
| 43 | Prepare Yourself For...Annex | comic story | 25 | script: Jack C. Harris; pencils: Tom Lyle; inks: Scott Hanna; colors: Bob Sharen; letters: Dave Sharpe | Annex [Alex Ellis] (introduction, origin); Dr. Hillman Barto; Davey Dunson; Abner Dunson (villain); General Colan Powell (cameo) |
| 44 | Dead Reckoning | comic story | 8 | script: Eric Fein; pencils: Scott Kolins; inks: Bud LaRosa; colors: John Kalisz; letters: Richard Starkings | Solo; Death-Storm (villain) |
| 45 | The Lizard Must Be Destroyed | comic story | 8 | script: Mike Lackey; pencils: Aaron Lopresti; inks: Andy Mushynsky; colors: Renee Witterstaetter; letters: Dave Sharpe | Guardsmen; Bud Jacobs; Dave Hopkins; Steven Bunche; Stegron (cameo) |
| 46 | Estrangements and Reunions | comic story | 8 | script: Eric Fein; pencils: Larry Alexander; inks: Bud LaRosa; colors: Rob Tokar; letters: Joe Rosen | Hector; Manuel Rourke; Samson Rourke (villain) |
| 47 | Maximum Carnage Cover Gallery | illustration | 5 | pencils: Ron Lim, Mark Bagley, Sal Buscema, Tom Lyle, Alex Saviuk; inks: Jim Sanders III, Randy Emberlin, Sal Buscema, Tom Lyle, Alex Saviuk | Spider-Man [Peter Parker]; Venom [Eddie Brock]; Carnage; Spider-Doppelganger; Deathlok; Demogoblin; J. Jonah Jameson; Black Cat [Felicia Hardy]; Shriek; Morbius |
| 48 | Amazing Spider-Man Annual #27 Trading Card | illustration | 1 | pencils: Tom Lyle; inks: Tom Lyle; colors: Paul Mounts | |
| 49 | Spider-Man: Invasion of the Spider-Slayers TPB Cover | cover reprint (on interior page) | 1 | | |
| 50 | Spider-Man: Invasion of the Spider-Slayers TPB Introduction | foreword, introduction, preface, afterword | 1 | script: David Michelinie | |
| 51 | The History of the Spider-Slayers | text article | 4 | script: Peter Sanderson | |
| 52 | Marvel Swimsuit Special #2 Pinup | illustration | 1 | script: Dan Slott; pencils: Kirk Jarvinen; inks: Kirk Jarvinen; colors: Brad Vancata | |
| 53 | Marvel Swimsuit Special #2 Pinup | illustration | 1 | script: Dan Slott; pencils: Lee Weeks; inks: Lee Weeks; colors: Tom Smith | |
| 54 | Best Wishes from Everyone at Mighty Marvel! | illustration | 1 | pencils: Steve Lightle; inks: Steve Lightle | Spider-Man [Peter Parker]; Mary Jane Watson |
| 55 | Amazing Spider-Man #372 Cover Art | illustration | 1 | pencils: Mark Bagley; inks: Randy Emberlin | |
| 56 | Amazing Spider-Man #373 Page 17 Art | illustration | 1 | pencils: Tod Smith; inks: Tod Smith | |
| 57 | Amazing Spider-Man #374 Page 10 Art | illustration | 1 | pencils: Mark Bagley; inks: Randy Emberlin | |
| 58 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Randy Emberlin; colors: Richard Isanove | |
| 59 | Epic Collection | promo (ad from the publisher) | 1 | letters: typeset | |
| 60 | The Spider-Slayers Are Back! | promo (ad from the publisher) | 1 | letters: typeset | |