| 0 | - | cover | 1 | pencils: Terry Dodson; inks: Rachel Dodson | Doctor Strange, Iron Fist, Namor, Norrin Radd, Danny Rand, Red She-Hulk, Betty Ross, Silver Surfer, Stephen Strange, Sub-Mariner |
| 1 | - | cover | 1 | pencils: Adam Kubert; colors: Morry Hollowell | Uatu the Watcher; Doctor Strange; Spider-Man [Peter Parker]; Nova [Sam Alexander]; Hawkeye [Clint Barton]; Red Prophet; Scarlet Spider [Kaine]; Phoenix Force; Ultron |
| 2 | The Shaman of Greenwich Village | comic story | 8 | script: Matt Fraction; pencils: Terry Dodson; inks: Rachel Dodson; colors: Sonia Oback; letters: Clayton Cowles; editing: Alejandro Arbona, Tom Brevoort, John Denning | Doctor Strange; Notebooks Joe Mitchell; Abby; Wong |
| 3 | Epilogue 4 | comic story | 4 | script: Matt Fraction; pencils: Terry Dodson; inks: Rachel Dodson; colors: Sonia Oback; letters: Clayton Cowles; editing: Alejandro Arbona, Tom Brevoort | Nul; Hulk; Doctor Strange; Wong |
| 4 | - | cover reprint (on interior page) | 1 | pencils: Terry Dodson; inks: Rachel Dodson | Defenders [Doctor Strange; Namor the Sub-Mariner; Silver Surfer; Red She-Hulk [Betty Ross]; Iron Fist] |
| 5 | Breaker of Worlds Part 1: I Hate Myself and Want to Die | comic story | 20 | script: Matt Fraction; pencils: Terry Dodson; inks: Rachel Dodson; colors: Sonia Oback; letters: Clayton Cowles | Nul; Defenders [Doctor Strange; Namor; Hulk; Silver Surfer; She-Hulk [Betty Ross]; Iron Fist]; Knights of Wundagore; Tagar; Prester John |
| 6 | - | cover reprint (on interior page) | 1 | pencils: Terry Dodson; inks: Rachel Dodson | Defenders [Doctor Strange; Iron Fist; Red She-Hulk [Betty Ross]] |
| 7 | Breaker of Worlds Part 2: The Prize of New Avalon | comic story | 20 | script: Matt Fraction; pencils: Terry Dodson; inks: Rachel Dodson; colors: Sonia Oback; letters: Clayton Cowles | Defenders [Iron Fist; Red She-Hulk [Betty Ross]; Doctor Strange; Silver Surfer; Namor the Sub-Mariner]; Knights of Wundagore; Count Tagar; Prester John; Nul |
| 8 | - | cover reprint (on interior page) | 1 | pencils: Terry Dodson; inks: Rachel Dodson | Nul; Defenders [Doctor Strange; Iron Fist; Silver Surfer; Namor the Sub-Mariner; Red She-Hulk [Betty Ross]] |
| 9 | Breaker of Worlds Part 3: The Man with Omega on His Palms | comic story | 20 | script: Matt Fraction; pencils: Terry Dodson; inks: Rachel Dodson; colors: Sonia Oback; letters: Clayton Cowles | Prester John; Nul; Knights of Wundagore; Defenders [Silver Surfer; Red She-Hulk [Betty Ross]; Iron Fist; Namor the Sub-Mariner; Dr. Strange] |
| 10 | - | cover reprint (on interior page) | 1 | pencils: Terry Dodson; inks: Rachel Dodson; colors: Sonia Oback | Doctor Strange |
| 11 | Misfits 1: Strange/The French Drop | comic story | 20 | script: Matt Fraction; pencils: Michael Lark; inks: Stefano Gaudiano; colors: Matt Hollingsworth; letters: Clayton Cowles | Defenders [Doctor Strange; Red She-Hulk [Betty Ross]; Iron Fist; Namor the Sub-Mariner]; Wong; Prester John; Molly; Martha |
| 12 | - | cover reprint (on interior page) | 1 | pencils: Terry Dodson; inks: Rachel Dodson | Defenders [Iron Fist; Silver Surfer; Namor the Sub-Mariner; Red She-Hulk [Betty Ross]] |
| 13 | The 99 Daughters of Pontus | comic story | 20 | script: Matt Fraction; pencils: Mitch Breitweiser; inks: Mitch Breitweiser; colors: Bettie Breitweiser, Mitch Breitweiser; letters: Clayton Cowles | Captain Nemo (flashback); Defenders [Namor the Sub-Mariner; Doctor Strange; Silver Surfer; She-Hulk [Betty Ross]]; Fen (flashback); Iron Fist; Jeryn Hogarth; Misty Knight; Fat Cobra |
| 14 | - | cover reprint (on interior page) | 1 | pencils: Terry Dodson; inks: Rachel Dodson; colors: Terry Dodson | Iron Fist; Misty Knight; Prince of Orphans; Fat Cobra |
| 15 | - | comic story | 20 | script: Matt Fraction; pencils: Victor Ibáñez; inks: Tom Palmer, Terry Pallot; colors: Chris Sotomayor; letters: Clayton Cowles | Fat Cobra; Misty Knight; Iron Fist [Daniel Rand]; Dog Brother Number One (dead); Tiger's Beautiful Daughter (dead); Bride of Nine Spiders (dead); John Aman; Captain America (flashback); Prester John; Silver Surfer; Iron Fist [Orson Randall]; Contessa (flashback); Shadu the Shady (flashback); Lucky P |
| 16 | - | cover reprint (on interior page) | 1 | pencils: Stuart Immonen; inks: Stuart Immonen; colors: Marte Gracia | Dr Strange |
| 17 | - | cover reprint (on interior page) | 1 | pencils: Neal Adams; inks: Nelson Dániel; colors: Paul Mounts | Defenders [Doctor Strange; Silver Surfer; Namor the Sub-Mariner; Red She-Hulk [Betty Ross]]; Hulk [Bruce Banner] |
| 18 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Mark Farmer; colors: Laura Martin | Red She-Hulk [Betty Ross] |
| 19 | - | cover reprint (on interior page) | 1 | pencils: Chris Stevens; inks: Chris Stevens; colors: José Villarrubia | Defenders [Doctor Strange; Iron Fist; Red She-Hulk [Betty Ross]] |
| 20 | - | cover reprint (on interior page) | 1 | pencils: Adam Kubert; inks: Adam Kubert; colors: Laura Martin | Silver Surfer; Galactus |
| 21 | - | cover reprint (on interior page) | 1 | pencils: Dale Keown; inks: Dale Keown; colors: Edgar Delgado | Iron Fist |
| 22 | - | cover reprint (on interior page) | 1 | pencils: Walter Simonson; inks: Walter Simonson; colors: Laura Martin | Namor the Sub-Mariner |
| 23 | - | cover reprint (on interior page) | 1 | | Iron Fist |
| 24 | - | cover reprint (on interior page) | 1 | | Doctor Strange |
| 25 | - | cover reprint (on interior page) | 1 | | Red She-Hulk [Betty Ross] |
| 26 | - | cover reprint (on interior page) | 1 | | Silver Surfer |
| 27 | - | cover reprint (on interior page) | 1 | | Hulk [Bruce Banner] |
| 28 | Matt Fraction Talks Defenders! | text article | 1 | script: Matt Fraction; pencils: Terry Dodson; inks: Rachel Dodson | |
| 29 | Terry Dodson Talks the Art of Defenders! | text article | 1 | script: Terry Dodson; pencils: Terry Dodson; inks: Rachel Dodson | |
| 30 | Who Are the Defenders | text article | 2 | script: Matt Fraction, Terry Dodson; pencils: Terry Dodson; inks: Rachel Dodson; colors: Sonia Oback | |
| 31 | Art of the Defenders | illustration | 2 | pencils: Terry Dodson; colors: Terry Dodson | Nul; Doctor Strange; Red She-Hulk [Betty Ross]; Iron Fist; Silver Surfer; Namor the Sub-Mariner |
| 32 | Meet Nul | text article | 1 | script: Matt Fraction, Terry Dodson; pencils: Terry Dodson; inks: Rachel Dodson; colors: Sonia Oback | Nul |