| 0 | untitled | cover | 1 | pencils: John Byrne; inks: John Byrne; colors: Avalon's Matt Milla | Human Torch; Invisible Girl; Mister Fantastic; The Thing |
| 1 | House Advertisement | promo (ad from the publisher) | 1 | | |
| 2 | Credits | credits, title page | 1 | pencils: John Byrne; inks: Terry Austin; colors: Jerron Quality Color | Human Torch; The Thing; Invisible Girl; Mister Fantastic |
| 3 | Cover - Fantastic Four #251 | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Thing; Mister Fantastic; Human Torch; Invisible Girl |
| 4 | Into the Negative Zone! | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak | Mister Fantastic; The Thing; Annihilus; Blastaar (flashback); Stygorr (flashback); Galactus (flashback); Invisible Girl; Human Torch; Julie Angel; Sharon Selleck; Grey Landers; Rolf Brandis; Franklin Richards; Alicia Masters |
| 5 | Cover - Fantastic Four #252 | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne; letters: Rick Parker | Thing; Mister Fantastic; Invisible Girl; Human Torch |
| 6 | Cityscape | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak | Taiya; Tannar; Human Torch; The Thing; Mister Fantastic; Invisible Girl; Mama Shonti; Franklin Richards; Annihilus; Ootah |
| 7 | Cover - Fantastic Four #253 | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Human Torch; Thing; Mister Fantastic; Invisible Girl; Captain [Kestorian] |
| 8 | Quest | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak | Kestorians [race]; Captain [Kestorian]; Mister Fantastic; Human Torch; The Thing; Invisible Girl; Julie Angel; Sharon Selleck; Annihilus |
| 9 | Cover - Fantastic Four #254 | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Mister Fantastic; Human Torch; Thing; Invisible Girl; Taranith Gelstal |
| 10 | The Minds of Matracora | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak | Taranith Gelstal [Ruler of Mantracora]; The Thing; Mister Fantastic; Human Torch; Invisible Girl; Annihilus; The Wasp; She-Hulk |
| 11 | Cover - Fantastic Four #255 | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne; letters: Michael Higgins | Invisible Girl; Mister Fantastic; Thing; Human Torch |
| 12 | Trapped! | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak | Daredevil; Annihilus; Alicia Masters; Franklin Richards; The Thing; Mister Fantastic; Human Torch; Invisible Girl; Taranith Gelstal [Ruler of Mantracora] |
| 13 | Cover - Avengers #233 | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: Joe Sinnott | Vision; She-Hulk; Scarlet Witch; Thor; Captain Marvel [Monica Rambeau]; Captain America; The Wasp; Starfox |
| 14 | The Annihilation Gambit! | comic story | 22 | script: Roger Stern, John Byrne; pencils: John Byrne; inks: Joe Sinnott; colors: Christie Scheele; letters: Jim Novak | Captain Marvel [Monica Rambeau]; The Wasp; Bernie Rosenthal; Captain America [Steve Rogers]; Annihilus; Alicia Masters; She-Hulk; Thor [Dr. Donald Blake]; Starfox; Haweye; Jorge; Scarlet Witch; Vision; Fantastic Four; Mister Fantastic; Human Torch; Invisible Girl; Franklin Richards |
| 15 | Cover - Fantastic Four #256 | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Annihilus; Invisible Girl; Mister Fantastic; The Thing; Human Torch |
| 16 | The Annihilation Gambit! | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak | The Thing; Mister Fantastic; Invisible Girl; Human Torch; Julie Angel; Sharon Selleck; The Skrulls; Nova [Frankie Raye]; Galactus; Annihilus; Captain Marvel [Monica Rambeau]; Alicia Masters; Avengers; The Wasp; Scarlet Witch; Thor; Captain America; She-Hulk; Starfox; Vision |
| 17 | Cover - The Thing #2 | cover reprint (on interior page) | 1 | pencils: Ron Wilson; inks: Joe Sinnott | Ben Grimm; Alynn Cambers; The Thing [background image] |
| 18 | For Beauty Passed Away | comic story | 22 | script: John Byrne; pencils: Ron Wilson; inks: John Byrne; colors: Bob Sharen; letters: Rick Parker | The Thing; Willie Lumpkin; Mister Fantastic; Invisible Girl; Jake Grimm; Alicia Masters; Alynn Cambers; Nan Freeman (flashback) |
| 19 | Cover - Fantastic Four #257 | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Mister Fantastic; Invisible Girl; The Thing; Human Torch; Nova [Frankie Raye]; Galactus; Death |
| 20 | Fragments | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak | Galactus; Death; Nova [Frankie Raye]; The Skrulls; Empress R'Klll; Princess Anelle; Human Torch; Julie Angel; Sharon Selleck; Norm Tobin; Jake Grimm; Mister Fantastic; Invisible Girl; The Thing; Franklin Richards; H.U.B.E.R.T.; Scarlet Witch; Vision |
| 21 | Cover - Fantastic Four Annual #17 | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Thing; Mister Fantastic; Invisible Girl; Human Torch |
| 22 | Legacy | comic story | 38 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak | Sharon Selleck; Barney White; Emmett; Chet Rollins (police chief); The Skrulls; Julie Angel; Roberta the Receptionist; Human Torch; Mister Fantastic; Invisible Girl; The Thing |
| 23 | House Advertisement | promo (ad from the publisher) | 1 | | |
| 24 | Marvel Subscription Form | promo (ad from the publisher) | 1 | | |
| 25 | Backcover | promo (ad from the publisher) | 1 | pencils: John Byrne; inks: John Byrne | Human Torch; Thing; Mister Fantastic; Invisible Girl; Captain [Kestorian] |