| 0 | - | cover | 1 | pencils: Patrick Scherberger; inks: Norman Lee; colors: Guru eFX | Spider-Man; Grey Gargoyle |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Patrick Scherberger; inks: Norman Lee; colors: Guru eFX | Spider-Man; Grey Gargoyle |
| 2 | Rock and Roll | comic story | 22 | script: Peter David; pencils: Pop Mhan; inks: Norman Lee; colors: Guru eFX; letters: Dave Sharpe | Spider-Man; Liz Allen; Flash Thompson; Grey Gargoyle (villain) |
| 3 | Next Month in Marvel Two-In-One #4 | preview (from the publisher) | 0.5 | pencils: Eric Nguyen; inks: Eric Nguyen; colors: Eric Nguyen | Beast; Iceman |
| 4 | Next Month Marvel Adventures Two-In-One #4 | preview (from the publisher) | 0.5 | pencils: Patrick Scherberger; inks: Norman Lee; colors: Guru eFX | Spider-Man; Whirlwind |
| 5 | Centerfold Poster | illustration | 2 | | Spider-Man |
| 6 | Marvel Two-In-One - Who's Who? | character profile | 1 | pencils: Patrick Scherberger; inks: Norman Lee; colors: Guru eFX | Grey Gargoyle |
| 7 | - | cover reprint (on interior page) | 1 | pencils: Paul Smith; inks: Paul Smith; colors: Christina Strain | Fantastic Four [Thing [Ben Grimm]; Human Torch [Johnny Storm]; Invisible Girl [Susan Storm]; Mister Fantastic [Reed Richards]] |
| 8 | What If...? | comic story | 22 | script: Fred Van Lente, Crystal Skillman; pencils: Cory Hamscher; inks: Cory Hamscher; colors: Lee Loughridge; letters: Dave Sharpe | Fantastic Four [Human Torch [Johnny Storm]; Thing [Ben Grimm]; Mister Fantastic [Reed Richards]; Invisible Girl [Susan Storm]]; Uatu the Watcher; Doc Iron [Victor von Doom]; Frightful Four [Monsterman [Ben Grimm]; Unstoppable Woman [Susan Storm]; Human Pyre [Johnny Storm]; Mister Devious [Reed Richa |
| 9 | Hulk Date | comic story | 4 | script: Chris Giarrusso; pencils: Chris Giarrusso; inks: Chris Giarrusso; colors: Chris Giarrusso; letters: Chris Giarrusso | Storm; Hulk; Thing; Hawkeye; Captain America; Thor; Iron Man; General Thaddeus "Thunderbolt" Ross; Betty Ross |