| 0 | - | cover | 1 | pencils: John Byrne; inks: John Byrne | Fantastic Four [Mr. Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]]; Annihilus |
| 1 | - | blank page(s) | 3 | | |
| 2 | - | credits, title page | 3 | letters: typeset | |
| 3 | - | illustration | 1 | pencils: John Byrne; inks: John Byrne | |
| 4 | - | table of contents | 1 | letters: typeset | |
| 5 | Introduction | foreword, introduction, preface, afterword | 4 | script: Al Milgrom | |
| 6 | Into the Negative Zone! | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Fantastic Four [Mister Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]] |
| 7 | Into the Negative Zone! | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak; editing: Tom DeFalco, Jim Shooter | Fantastic Four [Mister Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]]; Julie D'Angelo; Sharon Selleck; Grey Landers; Rolf Brandis; Franklin Richards; Alicia Masters; Annihilus (villain); Blastaar (on monitor); Stygorr (on monitor); |
| 8 | - | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne; letters: Rick Parker | Fantastic Four [Mister Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]] |
| 9 | Cityscape | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak; editing: Tom DeFalco, Jim Shooter | Fantastic Four [Mister Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; Thing [Ben Grimm]]; Ootha; Franklin Richards; Alicia Masters; Annihilus (villain) |
| 10 | - | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne; colors: Glynis Oliver | Kestorians |
| 11 | Quest | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak; editing: Al Milgrom, Jim Shooter | Kestorians |
| 12 | The Minds of -- Mantracora! | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Fantastic Four [Mister Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]]; Taranith Gelstal |
| 13 | The Minds of Mantracora | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak; editing: Al Milgrom, Jim Shooter | Fantastic Four [Mister Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]]; She-Hulk [Jennifer Walters]; Wasp [Janet Van Dyne]; Annihilus (villain); Taranith Gelstal (villain) |
| 14 | - | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne; letters: Michael Higgins | Fantastic Four [Mr. Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]] |
| 15 | Trapped! | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak; editing: Al Milgrom, Jim Shooter | Fantastic Four [Mr. Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]]; Daredevil [Matt Murdock]; Alicia Masters; Franklin Richards; Annihilus (villain); Taranith Gelstal (villain) |
| 16 | The Avengers Up Against... The Barrier! | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: Joe Sinnott | the Avengers [Captain America [Steve Rogers]; Captain Marvel [Monica Rambeau]; the Scarlet Witch; She-Hulk; Starfox; Thor [Donald Blake]; the Vision; the Wasp] |
| 17 | The Annihilation Gambit! | comic story | 22 | script: Roger Stern, John Byrne; pencils: John Byrne, Joe Sinnott; inks: Joe Sinnott; colors: Christie Scheele; letters: Jim Novak; editing: Mark Gruenwald, Jim Shooter | Alicia Masters; Annihilus; the Avengers [Captain America [Steve Rogers]; Captain Marvel [Monica Rambeau]; Hawkeye; the Scarlet Witch; She-Hulk; Starfox; Thor [also as Dr. Donald Blake]; the Vision; the Wasp]; Bernie Rosenthal; the Fantastic Four [the Human Torch [Johnny Storm]; the Invisible Girl; M |
| 18 | - | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Fantastic Four [Mr. Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]]; Annihilus |
| 19 | The Annihilation Gambit! | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak; editing: Al Milgrom, Jim Shooter | Fantastic Four [Mr. Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]]; Alicia Masters; Franklin Richards; The Avengers [Captain America [Steve Rogers]; Thor; Captain Marvel [Monica Rambeau]; She-Hulk; Starfox; Scarlet Witch; Vision; Wa |
| 20 | - | cover reprint (on interior page) | 1 | pencils: Ron Wilson; inks: Joe Sinnott | Ben Grimm; Alynn Cambers |
| 21 | For Beauty Passed Away | comic story | 22 | script: John Byrne; pencils: Ron Wilson; inks: John Byrne; colors: Bob Sharen; letters: Rick Parker; editing: Milgrom, Nocenti, Jim Shooter | The Thing; Willie Lumpkin; Mr. Fantastic; The Invisible Girl; Jake Grimm; Alicia Masters; Alynn Cambers; Nan Freeman |
| 22 | - | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Fantastic Four [Mr. Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]]; Galactus; Nova [Frankie Raye]; Death |
| 23 | Fragments | comic story | 22 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak; editing: Al Milgrom, Jim Shooter | Fantastic Four [Mr. Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; the Thing [Ben Grimm]]; Nova [Frankie Raye]; Scarlet Witch; Vision; Galactus (villain); Death (villain); Skrulls (villains); Franklin Richards (cameo); H.E.R.B.I.E. (cameo) |
| 24 | - | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | |
| 25 | Legacy | comic story | 38 | script: John Byrne; pencils: John Byrne; inks: John Byrne; colors: Glynis Wein; letters: Jim Novak; editing: Carl Potts, Jim Shooter | Tiny (first appearance, resembles Li'l Abner); Emmett (first appearance); Chet Rollins (first appearance); Barney White (first appearance); Grey Landers; Skrulls (flashback) |
| 26 | - | character profile | 80 | script: Mark Gruenwald | |
| 27 | - | illustration | 1 | pencils: Brent Anderson; inks: Brent Anderson | |
| 28 | - | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Fantastic Four [Mr. Fantastic [Reed Richards]; Invisible Girl [Sue Storm Richards]; Human Torch [Johnny Storm]; The Thing [Ben Grimm]]; Annihilus |
| 29 | - | illustration | 2 | script: John Byrne; pencils: John Byrne; inks: John Byrne; letters: Jim Novak | |
| 30 | - | illustration | 1 | pencils: John Byrne; inks: John Byrne | |
| 31 | - | illustration | 1 | pencils: John Byrne; inks: Terry Austin; colors: Avalon's Andy Troy | |
| 32 | Biographies | text article | 2 | script: John Rhett Thomas | |
| 33 | Marvel Masterworks | promo (ad from the publisher) | 1 | letters: typeset | |
| 34 | - | blank page(s) | 3 | | |
| 35 | - | promo (ad from the publisher) | 1 | pencils: various; inks: various; colors: various | |