| 0 | - | cover | 1 | pencils: Taurin Clarke; inks: Taurin Clarke; colors: Taurin Clarke | Aaron Davis, Ganke Lee, Billie Morales, Miles Morales, Prowler, Spider-Man, Spider-Smasher |
| 1 | - | promo (ad from the publisher) | 1 | letters: typeset | |
| 2 | - | credits, title page | 3 | letters: typeset | |
| 3 | 37 | cover reprint (on interior page) | 1 | pencils: Taurin Clarke; inks: Taurin Clarke; colors: Taurin Clarke | Miles Morales, Spider-Man |
| 4 | - | comic story | 20 | script: Saladin Ahmed; pencils: Chris Allen; inks: Chris Allen; colors: David Curiel; letters: VC's Cory Petit | Billie Morales, Miles Morales, Miles Morales, Selim, Shift, Spider-Man, Ultimatum, Aaron Davis, Aaron Davis, Mindspinner, Mindspinner, Miles Morales Death, Prowler, Prowler |
| 5 | 38 | cover reprint (on interior page) | 1 | pencils: Taurin Clarke; inks: Taurin Clarke; colors: Taurin Clarke | Billie Morales, Miles Morales, Shift, Spider-Man, Ganke Lee, Selim |
| 6 | Empire of the Spider Part One | comic story | 20 | script: Saladin Ahmed; pencils: Chris Allen, Alberto Foche; inks: Alberto Foche, Oren Junior, José Marzán Jr.; colors: Brian Reber; letters: VC's Cory Petit | Billie Morales, Miles Morales, Peter Parker, Shift, Spider-Man, Ganke Lee, Shift |
| 7 | #37 Spider-Man 60th Anniversary Variant | cover reprint (on interior page) | 0.25 | pencils: Mike McKone; inks: Mike McKone; colors: Israel Silva | Miles Morales, Spider-Man |
| 8 | #37 Variant | cover reprint (on interior page) | 0.25 | pencils: Kael Ngu; inks: Kael Ngu; colors: Kael Ngu | Miles Morales, Spider-Man |
| 9 | #38 Variant | cover reprint (on interior page) | 0.5 | pencils: Sergio Dávila; inks: Sean Parsons; colors: David Curiel | Miles Morales, Spider-Man |
| 10 | 39 | cover reprint (on interior page) | 1 | pencils: Taurin Clarke; inks: Taurin Clarke; colors: Taurin Clarke | Peter Parker, Spider-Man, Selim |
| 11 | Empire of the Spider Part Two | comic story | 20 | script: Saladin Ahmed; pencils: Alberto Foche; inks: Alberto Foche; colors: David Curiel; letters: VC's Cory Petit | Aaron Davis, Billie Morales, Miles Morales, Peter Parker, Prowler, Shift, Spider-Man, Ganke Lee, Mindspinner |
| 12 | 40 | cover reprint (on interior page) | 1 | pencils: Taurin Clarke; inks: Taurin Clarke; colors: Taurin Clarke | Aaron Davis, Billie Morales, Miles Morales, Prowler, Spider-Man |
| 13 | Empire of the Spider Part Three | comic story | 20 | script: Saladin Ahmed; pencils: Alberto Foche; inks: Alberto Foche; colors: David Curiel; letters: VC's Travis Lanham | Aaron Davis, Billie Morales, Miles Morales, Prowler, Shift, Spider-Man, Ganke Lee, Selim |
| 14 | 41 | cover reprint (on interior page) | 1 | pencils: Taurin Clarke; inks: Taurin Clarke; colors: Taurin Clarke | Aaron Davis, Billie Morales, Miles Morales, Prowler, Spider-Man, Spider-Smasher, Ganke Lee |
| 15 | Empire of the Spider Part Four | comic story | 20 | script: Saladin Ahmed; pencils: Chris Allen; inks: Chris Allen; colors: David Curiel; letters: VC's Cory Petit | Aaron Davis, Billie Morales, Miles Morales, Prowler, Shift, Spider-Man, Spider-Smasher, Ganke Lee, Selim |
| 16 | 42 | cover reprint (on interior page) | 1 | pencils: Taurin Clarke; inks: Taurin Clarke; colors: Taurin Clarke | Assessor, Aaron Davis, Ganke Lee, Billie Morales, Jefferson Morales, Miles Morales, Rio Morales, Prowler, Rhino, Spider-Man, Starling, Aleksei Sytsevich, Tiana Toomes |
| 17 | Empire of the Spider Part Five | comic story | 30 | script: Saladin Ahmed; pencils: Carmen Carnero, Paris Alleyne, Ig Guara, Paco Medina, Alitha E. Martinez, Natacha Bustos; inks: Carmen Carnero, Paris Alleyne, Ig Guara, Walden Wong, Alitha E. Martinez, Natacha Bustos; colors: David Curiel; letters: VC's Cory Petit | Aaron Davis, Jefferson Morales, Ganke Lee, Billie Morales, Miles Morales, Rio Morales, Rhino, Barbara Rodriguez, Shift, Spider-Man, Starling, Aleksei Sytsevich, Tiana Toomes, Judge |
| 18 | Afterword | foreword, introduction, preface, afterword | 1 | script: Saladin Ahmed, Tom Groneman | |
| 19 | #38 Skrull Variant | cover reprint (on interior page) | 0.25 | pencils: Ernanda Souza; inks: Ernanda Souza; colors: Ernanda Souza | Miles Morales, Spider-Man |
| 20 | #38 Variant | cover reprint (on interior page) | 0.25 | pencils: Jen Bartel; inks: Jen Bartel; colors: Jen Bartel | |
| 21 | #38 Spoiler Variant | cover reprint (on interior page) | 0.25 | pencils: Skan; inks: Skan; colors: Skan | |
| 22 | #38 Design Variant | cover reprint (on interior page) | 0.25 | pencils: Chris Allen; inks: Chris Allen; colors: Chris Allen | |
| 23 | #39 Hellfire Gala Variant | cover reprint (on interior page) | 0.25 | pencils: Russell Dauterman; inks: Russell Dauterman; colors: Russell Dauterman | |
| 24 | #39 Variant | cover reprint (on interior page) | 0.25 | pencils: Paco Medina; inks: Paco Medina; colors: Rachelle Rosenberg | Miles Morales, Peter Parker, Spider-Man, Spider-Man |
| 25 | #40 Variant | cover reprint (on interior page) | 0.25 | pencils: Stephen Segovia; inks: Stephen Segovia; colors: Rachelle Rosenberg | Miles Morales, Spider-Man |
| 26 | #41 Beyond Amazing Variant | cover reprint (on interior page) | 0.25 | pencils: Javier Rodríguez; inks: Javier Rodríguez; colors: Javier Rodríguez | Peter Parker, Mary Jane Watson |
| 27 | #42 Variant | cover reprint (on interior page) | 0.25 | pencils: Chris Allen; inks: Chris Allen; colors: Marte Gracia | Miles Morales, Spider-Man |
| 28 | #42 Miracleman Variant | cover reprint (on interior page) | 0.25 | pencils: Brian Stelfreeze; inks: Brian Stelfreeze; colors: Laura Martin | Miracleman, Miles Morales, Michael Moran, Spider-Man |
| 29 | #42 Community Variant | cover reprint (on interior page) | 0.5 | pencils: Leonardo Romero; inks: Leonardo Romero; colors: Leonardo Romero | Miles Morales, Spider-Man |
| 30 | - | promo (ad from the publisher) | 1 | letters: typeset | |
| 31 | - | promo (ad from the publisher) | 1 | pencils: Taurin Clarke; inks: Taurin Clarke; colors: Taurin Clarke | Ganke Lee, Billie Morales, Miles Morales, Selim, Shift, Spider-Man |