| 0 | - | cover | 1 | pencils: Federico Vicentini; inks: Federico Vicentini; colors: Alejandro Sánchez | Hobgoblin, Roderick Kingsley, Miles Morales, Peter Parker, Spider-Man, Spider-Man |
| 1 | - | promo (ad from the publisher) | 1 | pencils: Dike Ruan; inks: Dike Ruan; colors: Alejandro Sánchez | |
| 2 | - | credits, title page | 1 | letters: typeset | |
| 3 | Giant-Size Spider-Man 1 | cover reprint (on interior page) | 1 | pencils: Bryan Hitch; inks: Bryan Hitch; colors: Alex Sinclair | Dylan Brock, Miles Morales, Spider-Man, Venom |
| 4 | Lethal Protection | comic story | 20 | script: Cody Ziglar; pencils: Iban Coello; inks: Iban Coello; colors: Guru-eFX; letters: VC's Joe Caramagna | Dylan Brock, Hobgoblin, Roderick Kingsley, Misty Knight, Miles Morales, Rabble, Raneem Rashad, Spider-Man, Venom |
| 5 | 13 | cover reprint (on interior page) | 1 | pencils: Federico Vicentini; inks: Federico Vicentini; colors: Alejandro Sánchez | Hobgoblin, Roderick Kingsley, Miles Morales, Peter Parker, Spider-Man, Spider-Man |
| 6 | - | recap | 1 | letters: typeset | |
| 7 | Gang War Territories | illustration | 1 | letters: typeset | |
| 8 | - | comic story | 20 | script: Cody Ziglar; pencils: Federico Vicentini; inks: Federico Vicentini; colors: Bryan Valenza; letters: VC's Cory Petit | Aaron Davis, Frost Pharoah, Julia Gao, Mac Gargan, Gust, Hightail, Hobgoblin, Jade Jackson, Roderick Kingsley, Misty Knight, Miles Morales, Peter Parker, Sandra Santos, Scorpion |
| 9 | 14 | cover reprint (on interior page) | 1 | pencils: Federico Vicentini; inks: Federico Vicentini; colors: Alejandro Sánchez | Aaron Davis, Miles Morales, Prowler, Spider-Man |
| 10 | - | comic story | 20 | script: Cody Ziglar; pencils: Federico Vicentini; inks: Federico Vicentini; colors: Bryan Valenza; letters: VC's Cory Petit | Raymond Bloch, Jackson Brice, Daniel Brito, Aaron Davis, Fancy Dan, Julia Gao, Mac Gargan, Gust, Hightail, Hobgoblin, Jade Jackson, Kamala Khan, Roderick Kingsley, Misty Knight |
| 11 | 15 | cover reprint (on interior page) | 1 | pencils: Federico Vicentini; inks: Federico Vicentini; colors: Richard Isanove | Kamala Khan, Miles Morales, Ms. Marvel, Spider-Man |
| 12 | - | comic story | 20 | script: Cody Ziglar; pencils: Federico Vicentini, Federica Mancin; inks: Federico Vicentini, Federica Mancin; colors: Bryan Valenza; letters: VC's Cory Petit | Hobie Brown, Aaron Davis, Hobgoblin, Hornet, Kamala Khan, Roderick Kingsley, Lady Stilt-Man, Man-Bull, Miles Morales, Mister Fish, Ms. Marvel, Mortimer Norris, Prowler, Rabble |
| 13 | 16 | cover reprint (on interior page) | 1 | pencils: Federico Vicentini; inks: Federico Vicentini; colors: Richard Isanove | Hobgoblin, Roderick Kingsley, Luke Cage, Miles Morales, Peter Parker, She-Hulk, Spider-Man, Spider-Man, Jennifer Walters |
| 14 | Gang War Territories | illustration | 1 | letters: typeset | |
| 15 | - | comic story | 20 | script: Cody Ziglar; pencils: Federico Vicentini, Federica Mancin; inks: Federico Vicentini, Federica Mancin; colors: Bryan Valenza; letters: VC's Cory Petit | Julia Gao, Mac Gargan, Gust, Hobgoblin, Jade Jackson, Kamala Khan, Roderick Kingsley, Lady Stilt-Man, Man-Bull, Miles Morales, Mister Fish, Ms. Marvel, Mortimer Norris, Rabble |
| 16 | Giant-Size Spider-Man Variant | cover reprint (on interior page) | 0.25 | pencils: Alexander Lozano; inks: Alexander Lozano; colors: Romulo Fajardo Jr. | |
| 17 | Giant-Size Spider-Man Variant | cover reprint (on interior page) | 0.25 | pencils: Jeehyung Lee; inks: Jeehyung Lee; colors: Jeehyung Lee | |
| 18 | Giant-Size Spider-Man Deadly Foes Variant | cover reprint (on interior page) | 0.25 | pencils: Dave Bardin; inks: Dave Bardin; colors: Dave Bardin | |
| 19 | #13 Marvel's Spider-Man 2 Agimat Suit Variant | cover reprint (on interior page) | 0.25 | pencils: Anthony Francisco; inks: Anthony Francisco; colors: Anthony Francisco | |
| 20 | #13 Nightmare Variant | cover reprint (on interior page) | 0.25 | pencils: Peach Momoko; inks: Peach Momoko; colors: Peach Momoko | |
| 21 | #13 Variant | cover reprint (on interior page) | 0.25 | pencils: Dustin Nguyen; inks: Dustin Nguyen; colors: Dustin Nguyen | |
| 22 | #14 Variant | cover reprint (on interior page) | 0.25 | pencils: InHyuk Lee; inks: InHyuk Lee; colors: InHyuk Lee | |
| 23 | #15 Variant | cover reprint (on interior page) | 0.25 | pencils: Alan Quah; inks: Alan Quah; colors: Alan Quah | |
| 24 | #15 Wolverine Wolverine Wolverine Variant | cover reprint (on interior page) | 0.25 | pencils: Ken Lashley; inks: Ken Lashley; colors: Juan Fernandez | |
| 25 | #16 Variant | cover reprint (on interior page) | 0.25 | pencils: David Baldeón; inks: David Baldeón; colors: Jesus Aburtov | |
| 26 | #16 Black History Month Variant | cover reprint (on interior page) | 0.25 | pencils: Taurin Clarke; inks: Taurin Clarke; colors: Taurin Clarke | |
| 27 | #16 Stormbreakers Variant | cover reprint (on interior page) | 0.25 | pencils: Nic Klein; inks: Nic Klein; colors: Nic Klein | |
| 28 | - | promo (ad from the publisher) | 1 | pencils: Federico Vicentini; inks: Federico Vicentini; colors: Richard Isanove | |
| 29 | - | promo (ad from the publisher) | 1 | letters: typeset | |