| 0 | The Beginning of the End | cover | 1 | pencils: Gerald Parel; inks: Gerald Parel; colors: Gerald Parel | Leonardo da Vinci |
| 1 | Recap, credits and indicia | recap | 1 | letters: Todd Klein | |
| 2 | Terribilità | comic story | 20 | script: Jonathan Hickman; pencils: Dustin Weaver; inks: Dustin Weaver; colors: Sonia Oback; letters: Todd Klein | Leonardo da Vinci (1502 flashback); Michelangelo (also in 1502 flashback, 1630 flashback, 1645 flashback); Newton (also in 1642 flashback); Leonid (also in 1630 flashback); Deviants (1630 flashback); Morda (dies in 1630 flashback); Galileo (dies in 1642 flashback); Nostradamus (1645 flashback); Niko |
| 3 | Galileo's Gift | illustration | 1 | script: Jonathan Hickman; pencils: Kevin Mellon; inks: Kevin Mellon | |
| 4 | The Key | illustration | 1 | script: Jonathan Hickman; pencils: Kevin Mellon; inks: Kevin Mellon | |
| 5 | The Death of Morda | illustration | 1 | script: Jonathan Hickman; pencils: Kevin Mellon; inks: Kevin Mellon | |
| 6 | The Forever Man | illustration | 1 | script: Jonathan Hickman; pencils: Kevin Mellon; inks: Kevin Mellon | |
| 7 | Leonardo da Vinci | character profile | 1 | script: Rob London, Jeff Christiansen, Mike O'Sullivan, Roger Ott; pencils: Dustin Weaver; inks: Dustin Weaver; colors: Christina Strain | |
| 8 | Isaac Newton | character profile | 1 | script: Rob London, Jeff Christiansen, Mike O'Sullivan, Roger Ott; pencils: Dustin Weaver; inks: Dustin Weaver; colors: Christina Strain | |
| 9 | Nostradamus | character profile | 1 | script: Rob London, Jeff Christiansen, Mike O'Sullivan, Roger Ott; pencils: Dustin Weaver; inks: Dustin Weaver; colors: Christina Strain | |
| 10 | Zhang Heng | character profile | 1 | script: Rob London, Jeff Christiansen, Mike O'Sullivan, Roger Ott; pencils: Dustin Weaver; inks: Dustin Weaver; colors: Christina Strain | |
| 11 | Nathaniel Richards & Howard Stark | character profile | 1 | script: Rob London, Jeff Christiansen, Mike O'Sullivan, Roger Ott; pencils: Dustin Weaver; inks: Dustin Weaver; colors: Christina Strain | |
| 12 | Nikola Tesla | character profile | 1 | script: Rob London, Jeff Christiansen, Mike O'Sullivan, Roger Ott; pencils: Dustin Weaver; inks: Dustin Weaver; colors: Christina Strain | |
| 13 | Next Issue | promo (ad from the publisher) | 1 | pencils: Gerald Parel; inks: Gerald Parel; colors: Gerald Parel | Leonid; Nikola Tesla; Isaac Newton |