| 0 | - | cover | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Spider-Man [Peter Parker]; Alpha [Andrew Maguire] |
| 1 | Big Time | credits, title page | 1 | pencils: Giuseppe Camuncoli; inks: Klaus Janson; colors: Frank D'Armata | The Lizard [Curt Connors] |
| 2 | - | credits, title page | 2 | letters: typeset | Spider-Man [Peter Parker]; Alpha [Andrew Maguire] |
| 3 | - | cover reprint (on interior page) | 1 | pencils: Giuseppe Camuncoli; inks: Klaus Janson; colors: Frank D'Armata | Lizard [Curt Connors] |
| 4 | Daily Bugle | recap | 1 | pencils: various; inks: various; colors: various; letters: typeset | Spider-Man [Peter Parker]; Doctor Octopus [Otto Octavius]; Morbius; Silver Sable |
| 5 | No Turning Back Part 1: The Win Column | comic story | 20 | script: Dan Slott; pencils: Giuseppe Camuncoli; inks: Klaus Janson; colors: Frank D'Armata; letters: Joe Caramagna | Spider-Man [Peter Parker]; Lizard [Curt Connors]; Horizon Labs [Max Modell; Grady Scraps; Uatu Jackson; Sajani Jaffrey; Bella Fishbach; Tiberius Stone]; Hector Baez; Betty Brant; Flash Thompson; Randy Robertson; Glory Grant; Mary Jane Watson; Carlie Cooper; Morbius; Jensen |
| 6 | - | cover reprint (on interior page) | 1 | pencils: Giuseppe Camuncoli; inks: Klaus Janson; colors: Frank D'Armata | Spider-Man [Peter Parker]; Curt Connors; Morbius |
| 7 | No Turning Back Part 2: Cold Blooded | comic story | 20 | script: Dan Slott; pencils: Giuseppe Camuncoli; inks: Klaus Janson; colors: Frank D'Armata; letters: Joe Caramagna | Curt Connors [Lizard]; Spider-Man [Peter Parker]; Horizon Labs [Max Modell; Morbius; Bella Fishbach; Uatu Jackson; Tiberius Stone; Sajani Jaffrey; Grady Scraps]; Hector; Carlie Cooper; Madame Web [Julia Carpenter]; Rachel Carpenter |
| 8 | - | cover reprint (on interior page) | 1 | pencils: Giuseppe Camuncoli; inks: Klaus Janson; colors: Frank D'Armata | Spider-Man [Peter Parker]; Morbius; Curt Connors [Lizard] |
| 9 | No Turning Back Part 3: Natural State | comic story | 20 | script: Dan Slott; pencils: Giuseppe Camuncoli; inks: Klaus Janson, Dan Green, Giuseppe Camuncoli; colors: Frank D'Armata; letters: VC, Chris Eliopoulos | Spider-Man [Peter Parker]; Lizard [Curt Connors]; Horizon Labs [Max Modell; Tiberius Stone; Bella Fishbach; Grady Scraps; Uatu Jackson; Sajani Jaffrey]; Morbius; Madame Web [Julia Carpenter]; Kingpin; Hobgoblin [Phil Urich]; The Hand; Carlie Cooper; Hector Baez |
| 10 | - | cover reprint (on interior page) | 1 | pencils: Esad Ribić; inks: Esad Ribić; colors: Esad Ribić | Spider-Man [Peter Parker]; Lizard [Curt Connors] |
| 11 | - | cover reprint (on interior page) | 1 | pencils: Giuseppe Camuncoli; colors: Frank D'Armata | Spider-Man [Peter Parker]; Lizard [Curt Connors] |
| 12 | No Turning Back Part 4: Human Error | comic story | 20 | script: Dan Slott; pencils: Giuseppe Camuncoli, Mario del Pennino; inks: Klaus Janson, Dan Green; colors: Frank D'Armata; letters: Chris Eliopoulos | Spider-Man [Peter Parker]; Sajani Jaffrey; Carlie Cooper; Bella Fishbach; Grady Scraps; Lizard [Curt Connors]; Uatu Jackson; Hector; Max Modell; Morbius; Poindexter Stone; Kingpin; Hobgoblin [Phil Urich]; Madame Web [Julia Carpenter]; Devil Spider [Roderick Kingsley] |
| 13 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; colors: Edgar Delgado | Spider-Man [Peter Parker] |
| 14 | - | comic story | 1 | script: Fred Van Lente; pencils: John Romita Jr.; inks: Klaus Janson; colors: Dean White | Spider-Man [Peter Parker]; May Parker; Ben Parker (dead) |
| 15 | Alpha Part I: Point of Origin | comic story | 25 | script: Dan Slott; pencils: Humberto Ramos; inks: Victor Olazaba; colors: Edgar Delgado; letters: Chris Eliopoulos | Andy Maguire (introduction); Alice Maguire; Ray Maguire; Chrissy Chen; Mark Hunsacker; Paula Lake; Horizon Labs [Peter Parker [Spider-Man]; Max Modell; Tiberius Stone; Hector Baez]; Ms. Conway; Iron Man [Tony Stark]; Beast; Giant-Man [Hank Pym]; Fantastic Four [Mr. Fantastic; Thing; Human Torch; Inv |
| 16 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Alpha [Andrew Maguire] |
| 17 | Alpha Part 2: That Something Special | comic story | 20 | script: Dan Slott; pencils: Humberto Ramos; inks: Victor Olazaba; colors: Edgar Delgado; letters: Chris Eliopoulos | Fantastic Four [Mr. Fantastic [Reed Richards]; Thing [Ben Grimm]; Human Torch [Johnny Storm]; Invisible Woman[Susan Storm]]; Spider-Man [Peter Parker]; Alpha [Andrew Maguire]; Giganto; Mary Jane Watson; Chrissy Chen; Ray Maguire; Alice Maguire; Joan Conway; Paula Lake; Jackal; Princess; Spiderzons [ |
| 18 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Spider-Man [Peter Parker]; Alpha [Andrew Maguire] |
| 19 | Alpha Part 3: Final Grade | comic story | 20 | script: Dan Slott; pencils: Humberto Ramos; inks: Victor Olazaba; colors: Edgar Delgado; letters: Chris Eliopoulos | Alpha [Andrew Maguire]; Spider-Man [Peter Parker]; Ray Maguire; Alice Maguire; Jay Jameson; May Parker; Jonah Jameson; Glory Grant; Avengers [Thor; Iron Man [Tony Stark]; Captain America [Steve Rogers]; Captain Marvel [Carol Danvers]; Vision]; Terminus; Hobgoblin [Roderick Kingsley] |
| 20 | - | cover reprint (on interior page) | 1 | pencils: Chris Samnee; inks: Chris Samnee; colors: Javier Rodríguez | Spider-Man [Peter Parker]; Aunt May Parker |
| 21 | Previously... | recap | 1 | pencils: Steve Ditko | Peter Parker; Aunt May; Uncle Ben |
| 22 | - | comic story | 20 | script: Zeb Wells; pencils: Steve Dillon; inks: Steve Dillon; colors: Frank Martin; letters: VC, Joe Caramagna | Spider-Man [Peter Parker]; Copperhead; Aunt May Parker; Jay; Gwen Stacy (cameo flashback); Green Goblin [Norman Osborn] (cameo flashback); Punisher [Frank Castle] (cameo flashback) |
| 23 | - | cover reprint (on interior page) | 1 | pencils: Steve McNiven; inks: Steve McNiven | Spider-Man [Peter Parker]; Hobgoblin [Phil Urich]; Kingpin [Wilson Fisk] |
| 24 | Danger Zone Part One: Warning Signs | comic story | 20 | script: Dan Slott, Christos Gage; pencils: Giuseppe Camuncoli; inks: Dan Green; colors: Antonio Fabela; letters: Chris Eliopoulos | Hobgoblin [Phil Urich]; Spider-Man [Peter Parker]; Roderick Kingsley; Madame Web [Julia Carpenter]; Rachel Carpenter; Tiberius Stone; The Hand; Max Modell; Sally Floyd; Joe Robertson; Norah Winters; Kingpin [Wilson Fisk] |
| 25 | - | cover reprint (on interior page) | 1 | pencils: Steve McNiven; inks: Steve McNiven; colors: Simon West | Hobgoblin [Phil Urich] |
| 26 | Danger Zone Part Two: Key to the Kingdom | comic story | 20 | script: Dan Slott, Christos Gage; pencils: Giuseppe Camuncoli; inks: Dan Green; colors: Antonio Fabela; letters: Chris Eliopoulos | Spider-Man [Peter Parker]; Madame Web [Julia Carpenter]; Tiberius Stone; Kingpin [Wilson Fisk]; Hobgoblin [Phil Urich]; The Hand; Hobgoblin [Roderick Kingsley]; Max Modell; Uatu Jackson |
| 27 | - | cover reprint (on interior page) | 1 | pencils: Steve McNiven; inks: Steve McNiven; colors: Simon West | Spicer-Man [Peter Parker]; Hobgoblin [Phil Urich] |
| 28 | Danger Zone Part Three: War of the Goblins | comic story | 20 | script: Dan Slott; pencils: Giuseppe Camuncoli; inks: Dan Green, John Dell; colors: Antonio Fabela; letters: Chris Eliopoulos | Spider-Man [Peter Parker]; Max Modell; Hobgoblin [Phil Urich]; Hobgoblin [Roderick Kingsley]; Harry Osborn; Stanley Osborn; Kingpin [Wilson Fisk]; Tiberius Stone; Norah Winters; The Hand; Madame Web [Julia Carpenter]; Hitman (cameo); Blue Streak (cameo); Devil Spider (cameo); Blaze (cameo); Tumbler |
| 29 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Alpha [Andrew Maguire] |
| 30 | - | recap | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Alpha [Andrew Maguire] |
| 31 | I Used to Be Big Time | comic story | 20 | script: Joshua Fialkov; pencils: Nuno Plati; inks: Nuno Plati; colors: Nuno Plati; letters: Joe Sabino | Alpha [Andy Maguire]; Susan Rice; Duncan Kilgore; Markazenie; Peter Parker [Otto Octavius] |
| 32 | - | cover reprint (on interior page) | 1 | pencils: J. Scott Campbell; inks: J. Scott Campbell; colors: Edgar Delgado | Lizard [Curt Connors] |
| 33 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Alpha [Andrew Maguire] |
| 34 | Big Time Part Two | comic story | 20 | script: Joshua Fialkov; pencils: Nuno Plati; inks: Nuno Plati; colors: Nuno Plati; letters: Joe Sabino | Alpha [Andrew Maguire]; Susan Rice; Mrs. Maguire; Mona; Duncan Kilgore; Spider-Man [Otto Octavius] |
| 35 | - | cover reprint (on interior page) | 0.5 | pencils: Matthew Clark; inks: Tom Palmer; colors: Frank Martin | Lizard [Curt Connors] |
| 36 | - | cover reprint (on interior page) | 0.5 | pencils: Shane Davis; inks: Mark Morales; colors: Justin Ponsor | Lizard [Curt Connors] |
| 37 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Alpha [Andrew Maguire] |
| 38 | - | comic story | 20 | script: Joshua Fialkov; pencils: Nuno Plati; inks: Nuno Plati; colors: Nuno Plati; letters: Joe Sabino | Alpha [Andrew Maguire]; Spider-Man; Mrs. Maguire; Soupcan |
| 39 | - | cover reprint (on interior page) | 1 | pencils: Adam Kubert; inks: Joe Kubert; colors: Dean White | Lizard [Curt Connors] |
| 40 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Alpha [Andrew Maguire]; Thor |
| 41 | Big Time Part Four of Five | comic story | 20 | script: Joshua Fialkov; pencils: Nuno Plati; inks: Nuno Plati; colors: Nuno Plati; letters: Joe Sabino | Alpha [Andrew Maguire]; Thor; The Miller |
| 42 | - | cover reprint (on interior page) | 1 | pencils: Joe Quinones; inks: Joe Quinones; colors: Kelsey Shannon | Alpha [Andrew Maguire]; Spider-Man |
| 43 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Alpha [Andrew Maguire]; Spider-Man |
| 44 | Big Time! | comic story | 20 | script: Joshua Fialkov; pencils: Nuno Plati; inks: Nuno Plati; colors: Nuno Plati; letters: Joe Sabino | Alpha [Andrew Maguire]; Spider-Man |
| 45 | - | cover reprint (on interior page) | 1 | pencils: Marcos Martín; inks: Marcos Martín; colors: Marcos Martín | Peter Parker |
| 46 | - | cover reprint (on interior page) | 1 | pencils: Marcos Martín; inks: Marcos Martín; colors: Marcos Martín | Spider-Man [Peter Parker]; Gwen Stacy |
| 47 | - | cover reprint (on interior page) | 1 | pencils: Marcos Martín; inks: Marcos Martín; colors: Marcos Martín | Spider-Man [Peter Parker] |
| 48 | - | cover reprint (on interior page) | 1 | pencils: Marcos Martín; inks: Marcos Martín; colors: Marcos Martín | Spider-Man [Peter Parker] |
| 49 | - | cover reprint (on interior page) | 1 | pencils: Marcos Martín; inks: Marcos Martín; colors: Marcos Martín | Spider-Man [Peter Parker]; Spider-Woman [Jessica Drew]; Captain America [Steve Rogers]; Iron Man [Tony Starl]; Wolverine [Logan] |
| 50 | - | cover reprint (on interior page) | 1 | pencils: J. Scott Campbell; inks: J. Scott Campbell; colors: Edgar Delgado | Black Cat [Felicia Hardy]; Stan Lee; Spider-Man [Peter Parker]; May Parker; Mary-Jane Parker; Gwen Stacy |