| 0 | - | cover | 0 | pencils: Humberto Ramos; colors: Edgar Delgado | Peter Parker, Spider-Man |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; colors: Edgar Delgado | Spider-Man [Peter Parker] |
| 2 | Origin of Spider-Man | comic story | 1 | script: Fred Van Lente; pencils: John Romita Jr.; inks: Klaus Janson; colors: Dean White; letters: Nate Piekos | Spider-Man; May Parker; Ben Parker (dead) |
| 3 | Alpha Part I: Point of Origin | comic story | 25 | script: Dan Slott; pencils: Humberto Ramos; inks: Victor Olazaba; colors: Edgar Delgado; letters: Chris Eliopoulos | Andy Maguire (introduction); Alice Maguire; Ray Maguire; Chrissy Chen; Mark Hunsacker; Paula Lake; Horizon Labs [Peter Parker [Spider-Man]; Max Modell; Tiberius Stone; Hector Baez]; Ms. Conway; Iron Man [Tony Stark]; Beast; Giant-Man [Hank Pym]; Fantastic Four [Mr. Fantastic; Thing; Human Torch; Inv |
| 6 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Alpha |
| 7 | Alpha Part 2: That Something Special | comic story | 20 | script: Dan Slott; pencils: Humberto Ramos; inks: Victor Olazaba; colors: Edgar Delgado; letters: Chris Eliopoulos | Fantastic Four [Mr. Fantastic; Thing; Human Torch; Invisible Woman]; Spider-Man; Alpha; Giganto; Mary Jane Watson; Chrissy Chen; Ray Maguire; Alice Maguire; Joan Conway; Paula Lake; Jackal; Princess; Spiderzons [Queen Clones]; Frankie Kollins; Glory Grant; Max Modell; Hector Baez; May Parker; Jay Ja |
| 8 | The Amazing Spider-Man vs Alpha | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Spider-Man [Peter Parker]; Alpha |
| 9 | Alpha Part 3: Final Grade | comic story | 20 | script: Dan Slott; pencils: Humberto Ramos; inks: Victor Olazaba; colors: Edgar Delgado; letters: Chris Eliopoulos | Alpha [Andrew Maguire]; Ray Maguire; Alice Maguire; Jay Jameson; May Parker; Jonah Jameson; Glory Grant; Avengers [Thor; Iron Man; Captain America; Captain Marvel [Carol Danvers]; Vision]; Terminus; Hobgoblin [Roderick Kingsley] |
| 10 | - | cover reprint (on interior page) | 1 | pencils: Chris Samnee; inks: Chris Samnee; colors: Javier Rodríguez | Spider-Man [Peter Parker]; Aunt May Parker |
| 11 | - | comic story | 20 | script: Zeb Wells; pencils: Steve Dillon; inks: Steve Dillon; colors: Frank Martin Jr.; letters: VC, Joe Caramagna | Spider-Man [Peter Parker]; Copperhead; Aunt May Parker; Jay; Gwen Stacy (cameo flashback); Green Goblin [Norman Osborn] (cameo flashback); Punisher (cameo flashback) |
| 12 | - | cover reprint (on interior page) | 1 | pencils: Steve McNiven; inks: Steve McNiven | Spider-Man [Peter Parker]; Hobgoblin; Kingpin |
| 13 | Danger Zone Part One: Warning Signs | comic story | 20 | script: Dan Slott, Christos Gage; pencils: Giuseppe Camuncoli; inks: Dan Green; colors: Antonio Fabela; letters: Chris Eliopoulos | Hobgoblin [Phil Urich]; Spider-Man; Roderick Kingsley; Madame Web [Julia Carpenter]; Rachel Carpenter; Tiberius Stone; The Hand; Max Modell; Sally Floyd; Joe Robertson; Norah Winters; Kingpin |
| 14 | - | cover reprint (on interior page) | 1 | pencils: Steve McNiven; inks: Steve McNiven; colors: Simon West | Hobgoblin [Phil Urich]; Hobgoblin [Roderick Kingsley] |
| 15 | Danger Zone Part Two: Key to the Kingdom | comic story | 20 | script: Dan Slott, Christos Gage; pencils: Giuseppe Camuncoli; inks: Dan Green; colors: Antonio Fabela; letters: Chris Eliopoulos | Spider-Man; Madame Web [Julia Carpenter]; Tiberius Stone; Kingpin; Hobgoblin [Phil Urich]; The Hand; Hobgoblin [Roderick Kingsley]; Max Modell; Uatu Jackson |
| 16 | - | cover reprint (on interior page) | 1 | pencils: Steve McNiven; inks: Steve McNiven; colors: Simon West | Spider-Man [Peter Parker]; Hobgoblin |
| 17 | Danger Zone Part Three: Battle of the Goblins | comic story | 20 | script: Dan Slott; pencils: Giuseppe Camuncoli; inks: Dan Green, John Dell; colors: Antonio Fabela; letters: Chris Eliopoulos | Spider-Man; Max Modell; Hobgoblin [Phil Urich]; Hobgoblin [Roderick Kingsley]; Harry Osborn; Stanley Osborn; Kingpin; Tiberius Stone; Norah Winters; The Hand; Madame Web [Julia Carpenter]; Hitman (cameo); Blue Streak (cameo); Devil Spider (cameo); Blaze (cameo); Tumbler (cameo) |
| 18 | - | cover reprint (on interior page) | 0.5 | pencils: Marcos Martín; inks: Marcos Martín; colors: Marcos Martín | Peter Parker |
| 19 | - | cover reprint (on interior page) | 0.5 | pencils: Marcos Martín; inks: Marcos Martín; colors: Marcos Martín | Spider-Man [Peter Parker]; Gwen Stacy |
| 20 | - | cover reprint (on interior page) | 0.5 | pencils: Marcos Martín; inks: Marcos Martín; colors: Marcos Martín | Spider-Man [Peter Parker]; alien costume |
| 21 | - | cover reprint (on interior page) | 0.5 | pencils: Marcos Martín; inks: Marcos Martín; colors: Marcos Martín | Spider-Man [Peter Parker] |
| 22 | - | cover reprint (on interior page) | 0.5 | pencils: Marcos Martín; inks: Marcos Martín; colors: Marcos Martín | Avengers [Spider-Man [Peter Parker]; Wolverine [James Howlett]; Spider-Woman [Jessica Drew]; Iron Man [Tony Stark]; Captain America [Steve Rogers]] |
| 23 | - | cover reprint (on interior page) | 0.5 | pencils: J. Scott Campbell; inks: J. Scott Campbell; colors: Edgar Delgado | Black Cat [Felicia Hardy]; Stan Lee; Spider-Man [Peter Parker]; Mae Parker; Mary-Jane Parker; Gwen Stacy |
| 24 | Amazing Spider-Man #692 Letter Column | letters page | 1 | script: Steve Wacker, Dan Slott | |