| 0 | - | cover | 1 | pencils: David Williams; inks: David Williams; colors: Kelsey Shannon | Spider-Man; Iron Man |
| 1 | Credits | credits, title page | 1 | pencils: Ray Height; inks: Matthew Wiemann; colors: Lee Loughridge | |
| 2 | - | comic story | 22 | script: Kevin Grevioux; pencils: Ray Height; inks: Matthew Wiemann; colors: Lee Loughridge; letters: Blambot, Nate Piekos | Spider-Man; Iron Man (guest); Arsenal (villain) |
| 3 | With Friends Like These | comic story | 10 | script: Blambot's Nate Piekos; pencils: Zach Howard; inks: Carl Potts; colors: Brad Anderson; letters: Blambot, Nate Piekos | Spider-Man (feature); Iceman (guest); The Thing (guest); Gwen Stacy (guest) |
| 4 | Cover to Venom: Lethal Protector #2 | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Sam de la Rosa; editing: Danny Fingeroth | Venom [Eddie Brock] |
| 5 | Lethal Protector Part 2: War and Pieces | comic story | 23 | script: David Michelinie; pencils: Mark Bagley; inks: Sam de la Rosa, Al Milgrom; colors: Marie Javins; letters: Richard Starkings, Rick Parker; editing: Danny Fingeroth | Venom; Spider-Man (guest); Carl Brock (guest, Venom's Father); The Jury (villains); Diggers (villains) |
| 6 | Cover to Spider-Man: Death and Destiny #2 | cover reprint (on interior page) | 1 | pencils: Lee Weeks; inks: Lee Weeks; colors: Agustin Más; editing: Ralph Macchio | Spider-Man |
| 7 | Credits | credits, title page | 1 | pencils: Lee Weeks; inks: Richard Case; colors: Steve Buccellato | |
| 8 | Death and Destiny, Part Two: The Camera Doesn't Lie | comic story | 21 | script: Lee Weeks; pencils: Lee Weeks; inks: Richard Case; colors: Steve Buccellato; letters: Sharpefont, Paul Tutrone; editing: Ralph Macchio | Spider-Man; Aunt May; Mary Jane Watson; Flash Thompson; Gwen Stacy; Harry Osborn; Miles Warren; J. Jonah Jameson; Robbie Robertson; Dr. Octopus (villain); Captain George Stacy (cameo) |
| 9 | The Gravity of the Situation | comic story | 20 | script: Yamanaka Akira, Yuko Fukami, Marc Sumerak; pencils: Yamanaka Akira; inks: Yamanaka Akira; letters: Virtual Calligraphy, Joe Caramagna | Spider-Man J (feature); Detective Flynn (guest); Steel Scarab (villain); Lord Beastius (villain); General Wasperus (villain) |