| 0 | - | cover | 1 | pencils: Marko Djurdjević; inks: Marko Djurdjević; colors: Marko Djurdjević | Quentin Beck, Black Cat, Chameleon, Carlie Cooper, Max Dillon, Electro, Felicia Hardy, J. Jonah Jameson, Jay Jameson, Mysterio, Harry Osborn, May Parker, Peter Parker, Robbie Robertson |
| 1 | - | promo (ad from the publisher) | 1 | letters: typeset | |
| 2 | - | credits, title page | 3 | letters: typeset | |
| 3 | Amazing Spider-Man #642 | cover reprint (on interior page) | 1 | pencils: Marko Djurdjević; inks: Marko Djurdjević; colors: Marko Djurdjević | Anti-Venom, Eddie Brock, Mac Gargan, Morbius, Michael Morbius, Peter Parker, Rhino, Scorpion, Spider-Man, Aleksei Sytsevich, Venom, Vermin, Edward Whelan |
| 4 | Origin of the Species Part 1 | comic story | 23 | script: Mark Waid; pencils: Paul Azaceta; inks: Paul Azaceta; colors: Javier Rodríguez; letters: VC's Joe Caramagna | Quentin Beck, James Beverley, Betty Brant, Carlie Cooper, Esteban Corazón de Ablo, Diablo, Max Dillon, Doctor Octopus, Electro, Michele Gonzales, Hammerhead, Hippo, Lily Hollister, Martin Li |
| 5 | Amazing Spider-Man #643 | cover reprint (on interior page) | 1 | pencils: Marko Djurdjević; inks: Marko Djurdjević; colors: Marko Djurdjević | Esteban Corazón de Ablo, Piper Dali, Diablo, Kraven the Hunter, Anastasia Kravinoff, Sergei Kravinoff, Flint Marko, Molten Man, Paper Doll, Mark Raxton, Rhino, Sandman, Herman Schultz, Shocker |
| 6 | Origin of the Species Part 2 | comic story | 22 | script: Mark Waid; pencils: Paul Azaceta; inks: Paul Azaceta; colors: Javier Rodríguez; letters: VC's Joe Caramagna | Carlie Cooper, Max Dillon, Doctor Octopus, Electro, Lily Hollister, J. Jonah Jameson, Lonnie Lincoln, Flint Marko, Menace, Otto Octavius, Harry Osborn, Stanley Osborn, Peter Parker, Sandman |
| 7 | Amazing Spider-Man #644 | cover reprint (on interior page) | 1 | pencils: Marko Djurdjević; inks: Marko Djurdjević; colors: Marko Djurdjević | Curt Connors, Freak, Vin Gonzales, Lily Hollister, Martin Li, Lizard, Menace, Mister Negative, Norman Osborn |
| 8 | Origin of the Species Part 3 | comic story | 22 | script: Mark Waid; pencils: Paul Azaceta; inks: Paul Azaceta; colors: Javier Rodríguez; letters: VC's Joe Caramagna | Quentin Beck, Chameleon, Carlie Cooper, Doctor Octopus, Freak, Lily Hollister, Lonnie Lincoln, Mysterio, James Natale, Otto Octavius, Harry Osborn, Stanley Osborn, Peter Parker, Rhino |
| 9 | Amazing Spider-Man #645 | cover reprint (on interior page) | 1 | pencils: Marko Djurdjević; inks: Marko Djurdjević; colors: Marko Djurdjević | Black Cat, Felicia Hardy, J. Jonah Jameson, Jay Jameson, Harry Osborn, May Parker, Peter Parker, Robbie Robertson, Spider-Man, Flash Thompson, Ben Urich, Mary Jane Watson, Norah Winters |
| 10 | Origin of the Species Part Four | comic story | 22 | script: Mark Waid; pencils: Paul Azaceta, Matthew Southworth; inks: Paul Azaceta, Matthew Southworth; colors: Javier Rodríguez; letters: VC's Joe Caramagna | James Beverley, Ronald Bloch, Jackson Brice, Daniel Brito, Chameleon, Curt Connors, Carlie Cooper, Antoine Delsoin, Max Dillon, Doctor Octopus, Electro, Fancy Dan, Norton Fester, Lily Hollister |
| 11 | Amazing Spider-Man #646 | cover reprint (on interior page) | 1 | pencils: Marko Djurdjević; inks: Marko Djurdjević; colors: Marko Djurdjević | Quentin Beck, Chameleon, Carlie Cooper, Max Dillon, Electro, Mysterio, Dmitri Smerdyakov, Adrian Toomes, The Vulture |
| 12 | Origin of the Species Part Five | comic story | 22 | script: Mark Waid; pencils: Paul Azaceta, Matthew Southworth; inks: Paul Azaceta, Matthew Southworth; colors: Javier Rodríguez; letters: VC's Joe Caramagna | Curt Connors, Carlie Cooper, Doctor Octopus, Lily Hollister, Lizard, Otto Octavius, Harry Osborn, Stanley Osborn, Peter Parker, Spider-Man, Mary Jane Watson |
| 13 | Web of Spider-Man #12 | cover reprint (on interior page) | 1 | pencils: Jelena Kevic Djurdjevic; inks: Jelena Kevic Djurdjevic; colors: Jelena Kevic Djurdjevic | Doctor Octopus, Otto Octavius |
| 14 | Arms Against a Sea of Troubles | comic story | 11 | script: Roger Stern; pencils: Philippe Briones; inks: Philippe Briones; colors: Chris Sotomayor; letters: Dave Sharpe; editing: Tom Brennan | Doctor Octopus, Mary Octavius, Otto Octavius, Torbert Octavius, Peter Parker, Spider-Man |
| 15 | Amazing Spider-Man #647 | cover reprint (on interior page) | 1 | pencils: Marko Djurdjević; inks: Marko Djurdjević; colors: Marko Djurdjević | Bookie, Carrion, Doctor Octopus, Mac Gargan, Hammerhead, Hobgoblin, Jackal, Juggernaut, Roderick Kingsley, John Ladue, Cain Marko, Malcolm McBride, Otto Octavius, Scorpion |
| 16 | - | recap | 1 | letters: typeset | |
| 17 | - | credits, title page | 1 | letters: typeset | |
| 18 | Another Door | comic story | 24 | script: Fred Van Lente; pencils: Max Fiumara; inks: Max Fiumara; colors: Morry Hollowell; letters: VC's Joe Caramagna | James Beverley, Betty Brant, Carlie Cooper, Michele Gonzales, Vin Gonzales, Jay Jameson, Harry Osborn, Stanley Osborn, Overdrive, May Parker, Peter Parker, Spider-Man, Flash Thompson, Mary Jane Watson |
| 19 | Honor Thy Father | comic story | 5 | script: Zeb Wells; pencils: Michael Del Mundo; inks: Michael Del Mundo; colors: Michael Del Mundo; letters: VC's Joe Caramagna | Vin Gonzales, Harry Osborn, May Parker |
| 20 | Stand Off | comic story | 6 | script: Bob Gale; pencils: Karl Kesel; inks: Karl Kesel; colors: Antonio Fabela; letters: VC's Joe Caramagna | J. Jonah Jameson, Peter Parker, Spider-Man, Norah Winters |
| 21 | Norah's Last Night in NYC | comic story | 5 | script: Joe Kelly; pencils: J. M. Ken Niimura; inks: J. M. Ken Niimura; colors: J. M. Ken Niimura; letters: J. M. Ken Niimura | Peter Parker, Spider-Man, Norah Winters |
| 22 | J. Jonah Jameson - The Musical | comic story | 1 | script: Mark Waid; pencils: Paul Azaceta; inks: Paul Azaceta; colors: Morry Hollowell; letters: VC's Joe Caramagna | J. Jonah Jameson |
| 23 | American Hero | comic story | 5 | script: Marc Guggenheim; pencils: Graham Nolan; inks: Mark Pennington; colors: Antonio Fabela; letters: VC's Joe Caramagna | Flash Thompson |
| 24 | You Again | comic story | 6 | script: Fred Van Lente, Dan Slott; pencils: Adam Archer; inks: Adam Archer; colors: Antonio Fabela; letters: VC's Joe Caramagna | Ares, Betty Brant, Chameleon, Carlie Cooper, Piper Dali, Mac Gargan, Michele Gonzales, Gloria Grant, Hawkeye, Lily Hollister, Lester, Ms. Marvel, Harry Osborn, Stanley Osborn |
| 25 | Spider-Man Saga | cover reprint (on interior page) | 1 | pencils: J. Scott Campbell; inks: J. Scott Campbell; colors: Edgar Delgado | Anya Corazon, Peter Parker, Spider-Girl, Spider-Man |
| 26 | - | credits, title page | 1 | letters: typeset | |
| 27 | The Amazing Spider-Man | text article | 32 | script: Mike Fichera, Rob London, JD Korejko | |
| 28 | Amazing Spider-Man #642 Spidey vs. Variant | cover reprint (on interior page) | 1 | pencils: John Romita; inks: John Romita; colors: Laura Martin | Quentin Beck, Max Dillon, Doctor Octopus, Electro, Kraven the Hunter, Sergei Kravinoff, Flint Marko, Mysterio, Otto Octavius, Peter Parker, Sandman, Spider-Man, Adrian Toomes, The Vulture |
| 29 | Amazing Spider-Man #642 New York Comic Con Variant | cover reprint (on interior page) | 1 | pencils: John Romita, John Romita Jr.; inks: John Romita, John Romita Jr.; colors: Sonia Oback | |
| 30 | Amazing Spider-Man #643 Variant | cover reprint (on interior page) | 1 | pencils: Phil Jimenez; inks: Phil Jimenez; colors: Frank D'Armata | Peter Parker |
| 31 | Amazing Spider-Man #644 Variant | cover reprint (on interior page) | 1 | pencils: Chris Bachalo; inks: Tim Townsend | |
| 32 | Amazing Spider-Man #646 Variant | cover reprint (on interior page) | 1 | pencils: Paolo Rivera; inks: Paolo Rivera; colors: Paolo Rivera | Spider-Man [Peter Parker] |
| 33 | Amazing Spider-Man #645 Spidey vs. Variant | cover reprint (on interior page) | 2 | pencils: Bryan Hitch; inks: Bryan Hitch; colors: Paul Mounts | Quentin Beck, Max Dillon, Doctor Octopus, Electro, Green Goblin, Kraven the Hunter, Sergei Kravinoff, Flint Marko, Mysterio, Otto Octavius, Norman Osborn, Peter Parker, Sandman, Spider-Man |
| 34 | Amazing Spider-Man #645 Spidey vs. Variant | cover reprint (on interior page) | 2 | pencils: Bryan Hitch; inks: Bryan Hitch | Quentin Beck, Max Dillon, Doctor Octopus, Electro, Green Goblin, Kraven the Hunter, Sergei Kravinoff, Flint Marko, Mysterio, Otto Octavius, Norman Osborn, Peter Parker, Sandman, Spider-Man |
| 35 | Amazing Spider-Man #647 Variant | cover reprint (on interior page) | 1 | pencils: Steve McNiven; inks: Dexter Vines; colors: Justin Ponsor | Peter Parker, Spider-Man |
| 36 | Amazing Spider-Man #646 Vampire Variant | cover reprint (on interior page) | 1 | pencils: Mike Mayhew; inks: Mike Mayhew | |
| 37 | Amazing Spider-Man #643 Super Hero Squad Variant | cover reprint (on interior page) | 1 | pencils: Leonel Castellani; inks: Leonel Castellani; colors: Chris Sotomayor | Devil Dinosaur; Moon Boy; Wolverine |
| 38 | - | promo (ad from the publisher) | 1 | letters: typeset | |
| 39 | - | promo (ad from the publisher) | 1 | letters: typeset | |