| 0 | - | cover | 1 | pencils: Ron Lim; inks: Al Milgrom; colors: Thomas Mason | Peter Parker, Ben Reilly, Scarlet Spider, Spider-Man |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Steven Butler; inks: Steven Butler | Scarlet Spider |
| 2 | - | cover reprint (on interior page) | 1 | pencils: Sal Buscema; inks: Sal Buscema | Spider-Man; Ben Reilly; Doctor Judas Traveller |
| 3 | - | credits, title page | 1 | letters: typeset | |
| 4 | Birth of a Spider-Man, Part 1 | cover reprint (on interior page) | 1 | pencils: Steven Butler; inks: Steven Butler | Ben Reilly |
| 5 | The Double, Part 1 of 4: Born Again | comic story | 9 | script: J. M. DeMatteis; pencils: Liam Sharp; inks: Robin Riggs; colors: John Kalisz; letters: Bill Oakley | Ben Reilly (clone of Peter Parker); Professor Miles Warren [The Jackal] |
| 6 | Birth of a Spider-Man, Part 2 | cover reprint (on interior page) | 1 | pencils: Bags; inks: Larry Mahlstedt | Spider-Man; Jackal; Peter Parker Clone; Gwen Stacy Clone |
| 7 | The Double Part 2: No Escape | comic story | 10 | script: J. M. DeMatteis; pencils: Liam Sharp; inks: Robin Riggs; colors: John Kalisz; letters: Steve Dutro | Ben Reilly [Scarlet Spider]; Gwen Stacy clone; Jackal |
| 8 | Birth of a Spider-Man, Part 3 | cover reprint (on interior page) | 1 | pencils: Tom Lyle; inks: Tom Lyle | Spider-Man |
| 9 | The Double, Part 3: Who Am I? | comic story | 10 | script: J. M. DeMatteis; pencils: Liam Sharp; inks: Robin Riggs; colors: John Kalisz; letters: Steve Dutro | Spider-Man [Peter Parker]; Ben Reilly (clone of Peter Parker); The Jackal [Professor Miles Warren] (villain) |
| 10 | Birth of a Spider-Man, Finale [Part 4] | cover reprint (on interior page) | 1 | pencils: Sal Buscema; inks: Sal Buscema | Spider-Man |
| 11 | The Double, Part Four: The Burial | comic story | 10 | script: J. M. DeMatteis; pencils: Liam Sharp; inks: Robin Riggs; colors: John Kalisz; letters: Joe Rosen | Spider-Man [Peter Parker]; Ned Leeds; Mary Jane Watson; Ben Reilly (clone of Peter Parker); Gwen Stacy clone; The Jackal [Professor Miles Warren] (villain) |
| 12 | - | recap | 1 | letters: typeset | |
| 13 | The Parker Legacy, Part One of Three: A Shock to the System | comic story | 7 | script: J. M. DeMatteis; pencils: John Romita Jr.; inks: John Romita; colors: Paul Becton; letters: Ken Lopez | Ben Reilly (Peter Parker's clone) |
| 14 | The Parker Legacy, Part Two of Three: Whose Life Is It, Anyway? | comic story | 9 | script: J. M. DeMatteis; pencils: John Romita Jr.; inks: John Romita; colors: Paul Becton; letters: Joe Rosen | Ben Reilly (Peter Parker's clone); Clifford Gross; Aunt May Parker |
| 15 | The Parker Legacy, Part Three of Three: The Beginning | comic story | 10 | script: J. M. DeMatteis; pencils: John Romita Jr.; inks: Al Milgrom; colors: Paul Becton; letters: Bill Oakley | Ben Reilly (Peter Parker's clone); Clifford Gross |
| 16 | - | cover reprint (on interior page) | 1 | pencils: John Romita Jr.; inks: Klaus Janson | Ben Reilly |
| 17 | Strangers | comic story | 27 | script: J. M. DeMatteis; pencils: John Romita Jr.; inks: Klaus Janson; colors: Christie Scheele; letters: Richard Starkings, Comicraft | Janine Godbe, Kaine, Ben Reilly |
| 18 | - | promo (ad from the publisher) | 1 | pencils: John Romita Jr.; inks: Klaus Janson | Ben Reilly |
| 19 | - | cover reprint (on interior page) | 1 | pencils: John Romita Jr.; inks: Klaus Janson | Spider-Man; Kaine; Ben Reilly |
| 20 | Intimacies | comic story | 27 | script: J. M. DeMatteis; pencils: John Romita Jr.; inks: Klaus Janson; colors: Christie Scheele, Heroic Age; letters: Richard Starkings, Comicraft | Ben Reilly; Kaine; Jacob Raven; Louise Kennedy |
| 21 | - | promo (ad from the publisher) | 1 | pencils: John Romita Jr.; inks: Klaus Janson | |
| 22 | - | cover reprint (on interior page) | 1 | pencils: John Romita Jr.; inks: Klaus Janson | Spider-Man; Ben Reilly; Louise Kennedy |
| 23 | The Truth | comic story | 32 | script: J. M. DeMatteis; pencils: John Romita Jr.; inks: Klaus Janson; colors: Christie Scheele, Heroic Age; letters: Richard Starkings, Comicraft | Ben Reilly; Kaine; Jacob Raven; Louise Kennedy |
| 24 | - | promo (ad from the publisher) | 1 | pencils: John Romita Jr.; inks: Klaus Janson | |
| 25 | Previously... | recap | 1 | letters: typeset | |
| 26 | - | comic story | 2 | script: Terry Kavanagh; pencils: Alex Saviuk; inks: Fred Fredericks; colors: Kevin Tinsley; letters: Steve Dutro | Aunt May; Ben Reilly |
| 27 | - | comic story | 3 | script: J. M. DeMatteis; pencils: Mark Bagley; inks: Randy Emberlin; colors: Bob Sharen; letters: Jim Novak | Aunt May; Mary Jane Watson |
| 28 | - | comic story | 1 | script: Howard Mackie; pencils: Tom Lyle; inks: Scott Hanna; colors: Kevin Tinsley; letters: Richard Starkings, Comicraft | |
| 29 | - | comic story | 2 | script: Terry Kavanagh; pencils: Alex Saviuk; inks: Don Hudson; colors: Kevin Tinsley; letters: Steve Dutro | |
| 30 | - | comic story | 1 | script: Howard Mackie; pencils: Tom Lyle; inks: Joe Rubinstein; colors: Kevin Tinsley; letters: Richard Starkings, Comicraft | Ben Reilly |
| 31 | - | comic story | 2 | script: Tom DeFalco, Mike Lackey; pencils: Sal Buscema; inks: Sal Buscema; colors: Glynis Oliver; letters: Clem Robins | Ben Reilly; Spider-Man |
| 32 | - | comic story | 4 | script: Terry Kavanagh; pencils: Alex Saviuk; inks: Don Hudson; colors: Kevin Tinsley; letters: Steve Dutro | |
| 33 | - | comic story | 7 | script: J. M. DeMatteis; pencils: Mark Bagley; inks: Randy Emberlin; colors: Bob Sharen; letters: Joe Rosen | Ben Reilly |
| 34 | - | comic story | 5 | script: Howard Mackie; pencils: Tom Lyle; inks: Scott Hanna; colors: Kevin Tinsley; letters: Richard Starkings, Comicraft | Ben Reilly; Spider-Man |
| 35 | - | comic story | 6 | script: Tom DeFalco, Todd DeZago; pencils: Sal Buscema; inks: Sal Buscema; colors: Joe Andreani; letters: Chris Eliopoulos, Clem Robins, Ken Lopez | |
| 36 | Power and Responsibility, Part 1 | cover reprint (on interior page) | 1 | pencils: Steven Butler; inks: Randy Emberlin; letters: Todd Klein | Spider-Man; Ben Reilly |
| 37 | Power and Responsibility, Part 1 of 4: Shadow Rising | comic story | 22 | script: Terry Kavanagh; pencils: Steven Butler; inks: Randy Emberlin; colors: Kevin Tinsley; letters: Steve Dutro | Spider-Man [Peter Parker]; Ben Reilly; Mary Jane Watson-Parker; Aunt May Parker; Anna Watson; Colonel John Jameson; Doctor Ashley Kafka; Doctor Judas Traveller (villain); Chakra (villain); Boone (villain); Mr. Nacht (villain); Medea (villain); Chameleon [Dmitri Smerdyakov] (villain); Shriek [Frances |
| 38 | Power and Responsibility Part 2 | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Larry Mahlstedt; letters: Todd Klein | Spider-Man [Peter Parker]; Judas Traveller; Ben Reilly |
| 39 | Power and Responsibility, Part 2: Breakdown! | comic story | 23 | script: J. M. DeMatteis; pencils: Mark Bagley; inks: Larry Mahlstedt; colors: Bob Sharen; letters: Joe Rosen | Spider-Man [Peter Parker]; Ben Reilly; Traveller; Mr. Nacht; Scrier; Chakra; Mary Jane Parker; Aunt May Parker; Chameleon (villain); Vermin (villain); Carnage (villain) |
| 40 | Power and Responsibility, Part 3 | cover reprint (on interior page) | 1 | pencils: Tom Lyle; inks: Tom Lyle; letters: Todd Klein | Spider-Man |
| 41 | Power and Responsibility, Part 3 of 4: A Heart Beat Away! | comic story | 22 | script: Howard Mackie; pencils: Tom Lyle; inks: Scott Hanna; colors: Kevin Tinsley; letters: Richard Starkings, Comicraft | Spider-Man [Peter Parker]; Ben Reilly [Scarlet Spider]; Aunt May Parker; John Jameson [Man-Wolf]; Doctor Caputo; Doctor Judas Traveller (villain); Mr. Boone (villain); Mr. Nacht (villain); Medea (villain) |
| 42 | Power and Responsibility, Finale [Part 4] | cover reprint (on interior page) | 1 | pencils: Sal Buscema; inks: Sal Buscema; letters: Todd Klein | Spider-Man; Ben Reilly; Doctor Judas Traveller |
| 43 | Power and Responsibility, Part 4 of 4: Higher Ground! | comic story | 22 | script: Tom DeFalco; pencils: Sal Buscema; inks: Sal Buscema; colors: Kevin Tinsley; letters: Clem Robins | Spider-Man [Peter Parker]; Ben Reilly [Scarlet Spider]; Mary Jane Watson-Parker; John Jameson [Man-Wolf]; Doctor Ashley Kafka; Edward Whelan [Vermin]; Doctor Judas Traveller (villain); Scrier (villain); Chakra (villain); Mr. Boone (villain); Mr. Nacht (villain); Medea (villain); Carnage [Cletus Kasa |
| 44 | The Exile Returns Part 1 of 4 | cover reprint (on interior page) | 1 | pencils: Steven Butler; inks: Steven Butler; letters: Todd Klein | Scarlet Spider |
| 45 | The Exile Returns, Part 1 of 4: Memories | comic story | 22 | script: Terry Kavanagh; pencils: Steven Butler; inks: Randy Emberlin; colors: Kevin Tinsley; letters: Steve Dutro | Scarlet Spider (first appearance) [Ben Reilly]; Aunt May Parker; Betty Brant; Anna Watson; Ken Ellis; Venom [Eddie Brock] (villain) |
| 46 | - | cover reprint (on interior page) | 1 | pencils: Ron Lim; inks: Al Milgrom; letters: Todd Klein | Spider-Man; Scarlet Spider |
| 47 | Second Rate Choices | comic story | 24 | script: Tom Lyle; pencils: Ron Lim, Tom Palmer, Phil Gosier; inks: Tom Palmer; colors: John Kalisz; letters: Joe Rosen | Scarlet Spider [Ben Reilly]; Peter Parker [Spider-Man]; Aunt May Parker; Rich Gannon |
| 48 | The Exile Returns, Part 2 of 4 | cover reprint (on interior page) | 1 | pencils: Tom Lyle; inks: Tom Lyle; letters: Todd Klein | Scarlet Spider [Ben Reilly]; Venom [Eddie Brock] |
| 49 | [The Exile Returns, Part 2 of 4]: Deadline | comic story | 22 | script: Howard Mackie; pencils: Tom Lyle; inks: Scott Hanna; colors: Kevin Tinsley; letters: Richard Starkings, Comicraft | Scarlet Spider [Ben Reilly]; Ken Ellis; Venom [Eddie Brock] (villain); Scream [Donna] (villain) |
| 50 | The Exile Returns Part 3 of 4 | cover reprint (on interior page) | 1 | pencils: Steven Butler; letters: Todd Klein | Eddie Brock, Ben Reilly, Scarlet Spider, Venom |
| 51 | The Exile Returns, Part 3 of 4: Echoes of Silence | comic story | 22 | script: Terry Kavanagh; pencils: Steven Butler, Randy Emberlin; inks: Randy Emberlin; colors: Kevin Tinsley; letters: Steve Dutro | Eddie Brock, Donna Diego, Kaine, Ben Reilly, Scarlet Spider, Scream, Venom |
| 52 | The Exile Returns, Part 4 of 4 | cover reprint (on interior page) | 1 | pencils: Tom Lyle; inks: Tom Lyle; letters: Todd Klein | Scarlet Spider; Venom |
| 53 | [The Exile Returns, Part 4 of 4]: Gathering Storms | comic story | 22 | script: Howard Mackie; pencils: Tom Lyle; inks: Scott Hanna; colors: Kevin Tinsley; letters: Richard Starkings, Comicraft | Scarlet Spider [Ben Reilly]; J. Jonah Jameson; Ken Ellis; Jacob Raven; Mr. Thorpe; Venom [Eddie Brock] (villain); Scream [Donna] (villain); Grim Hunter [Vladimir Kravinoff] (villain); Kaine (villain) |
| 54 | Power and Responsibility Part 1 | cover reprint (on interior page) | 1 | pencils: Steven Butler; inks: Steven Butler | Ben Reilly |
| 55 | Power and Responsibility Part 2 | cover reprint (on interior page) | 1 | pencils: Bags; inks: Larry Mahlstedt | Spider-Man; Jackal; Peter Parker Clone; Gwen Stacy Clone |
| 56 | Power and Responsibility Part 3 | cover reprint (on interior page) | 1 | pencils: Tom Lyle; inks: Tom Lyle | Spider-Man |
| 57 | Power and Responsibility, Finale [Part 4] | cover reprint (on interior page) | 1 | pencils: Sal Buscema; inks: Sal Buscema; letters: Todd Klein | Spider-Man; Ben Reilly; Doctor Judas Traveller |
| 58 | - | cover reprint (on interior page) | 2 | pencils: John Romita Jr.; inks: Klaus Janson | |
| 59 | - | cover reprint (on interior page) | 1 | pencils: John Romita Jr.; inks: John Romita; colors: Atomic Paintbrush | Spider-Man |
| 60 | Spider-Man Sketch File | illustration | 1 | pencils: Tom Lyle, Mark Bagley | Boone; Mr. Nacht |
| 61 | Carnage | character profile | 1 | pencils: Shawn McManus; inks: Shawn McManus | Carnage [Cletus Kasady] |
| 62 | Chameleon | character profile | 1 | pencils: Steven Butler; inks: Steven Butler; colors: José Villarrubia | Chameleon [Dmitri Smerdyakov] |
| 63 | Edward Whelan [Vermin] | character profile | 1 | letters: typeset | Vermin [Edward Whelan] |
| 64 | - | foreword, introduction, preface, afterword | 2 | script: J. M. DeMatteis | |
| 65 | - | promo (ad from the publisher) | 1 | pencils: Steven Butler; inks: Randy Emberlin; letters: Todd Klein | Spider-Man; Ben Reilly |