| 0 | - | cover | 1 | pencils: John Romita Jr.; inks: Scott Hanna | Eddie Brock, J. Jonah Jameson, Peter Parker, Spider-Man, Venom |
| 1 | - | promo (ad from the publisher) | 1 | letters: typeset | |
| 2 | - | credits, title page | 1 | letters: typeset | |
| 3 | Brave New World! | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne; colors: Liquid! | Spider-Man, Flash Thompson |
| 4 | Heroes & Villains | comic story | 22 | script: Howard Mackie; pencils: John Byrne; inks: Scott Hanna; colors: Gregory Wright; letters: RS, Comicraft's Liz Agraphiotis | Annihilus, Blastaar, Betty Brant, Doctor Doom, Victor Von Doom, Ben Grimm, Human Torch, Invisible Woman, Iron Man, J. Jonah Jameson, Mister Fantastic, Norman Osborn, May Parker, Ben Parker |
| 5 | - | illustration | 1 | letters: typeset | |
| 6 | You Won't Believe Who Kills Spider-Man This Issue! | cover reprint (on interior page) | 1 | pencils: John Romita Jr.; inks: John Romita Jr.; colors: Liquid! | J. Jonah Jameson, Harry Osborn, May Parker, Ben Parker, Peter Parker, Robbie Robertson, Spider-Man, Mary Jane Watson |
| 7 | The Man Behind the Curtain! | comic story | 22 | script: Howard Mackie; pencils: John Byrne; inks: Scott Hanna; colors: Joe Rosas; letters: RS, Comicraft's Liz Agraphiotis | Beetle, Morrie Bench, Daniel Berkhart, Eddie Brock, Carrion, Chameleon, Max Dillon, Doctor Octopus, Electro, Robert Farrell, Wilson Fisk, Mac Gargan, Green Goblin, Hammerhead |
| 8 | - | illustration | 1 | letters: typeset | |
| 9 | - | illustration | 1 | letters: typeset | |
| 10 | The Hunger and the Hunter! | cover reprint (on interior page) | 1 | pencils: John Romita Jr.; inks: Scott Hanna | Blade, Eric Brooks, Loxias Crown, Hunger, Peter Parker, Spider-Man |
| 11 | Creatures of the night | comic story | 23 | script: Howard Mackie; pencils: John Romita Jr.; inks: Scott Hanna; colors: Mark Bernardo; letters: Richard Starkings, Comicraft | Blade, Eric Brooks, Loxias Crown, Wilson Fisk, Giacomo Fortunato, Hunger, Jimmy-Six, Kingpin, Peter Parker, Spider-Man, Jill Stacy |
| 12 | - | illustration | 1 | letters: typeset | |
| 13 | A Secret Revealed! A Demon Unleashed! | cover reprint (on interior page) | 1 | pencils: John Romita Jr.; inks: Scott Hanna | Blade, Eric Brooks, Wilson Fisk, Kingpin, Morbius, Michael Morbius, Peter Parker, Spider-Man |
| 14 | Blood Feud | comic story | 22 | script: Howard Mackie; pencils: John Romita Jr.; inks: Scott Hanna; colors: Gregory Wright; letters: Liz Agraphiotis, Comicraft, RS | Blade, Betty Brant, Eddie Brock, Eric Brooks, Wilson Fisk, Giacomo Fortunato, Jimmy-Six, Kingpin, Morbius, Michael Morbius, Peter Parker, Robbie Robertson, Spider-Man, Jill Stacy |
| 15 | - | illustration | 1 | letters: typeset | |
| 16 | Song of the Man-Thing | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones | Man-Thing, Peter Parker, Ted Sallis, Spider-Man |
| 17 | Song of the Man-Thing | comic story | 38 | script: J. M. DeMatteis; pencils: Al Rio, Liam Sharp; inks: Dan Schaefer; colors: John Kalisz, Liam Sharp; letters: Richard Starkings, Comicraft | Charles Bates, Man-Thing, May Parker, Ben Parker, Peter Parker, Ted Sallis, Scrier, Scrier, Spider-Man, Gwen Stacy, Flash Thompson, Mary Jane Watson |
| 18 | - | illustration | 1 | letters: typeset | |
| 19 | To Save a Life-- Spidey Must Plunge-- --Into the Inferno! | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne; colors: Liquid! | Peter Parker, Spider-Man |
| 20 | The List | comic story | 22 | script: Howard Mackie; pencils: John Byrne; inks: Ray Kryssing; colors: Gregory Wright; letters: Richard Starkings, Comicraft | Doctor Octopus, Gloria Grant, Otto Octavius, Peter Parker, Spider-Man, Arthur Stacy, Jill Stacy, Paul Stacy, Mary Jane Watson |
| 21 | - | illustration | 1 | letters: typeset | |
| 22 | The Good, the Bad, and ... the Survivor! | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Captain Power, Chris Carr, Doctor Octopus, Otto Octavius, Peter Parker, Spider-Man |
| 23 | And Then There Were ... | comic story | 22 | script: Howard Mackie; pencils: John Byrne; inks: Scott Hanna; colors: Gregory Wright; letters: Comicraft's Liz Agraphiotis, RS | Captain Power, Chris Carr, Doctor Octopus, Otto Octavius, May Parker, Peter Parker, Spider-Man, Jill Stacy, Paul Stacy, Mary Jane Watson |
| 24 | The Horror Returns! Venom Is Back! | cover reprint (on interior page) | 1 | pencils: John Romita Jr.; inks: Scott Hanna; colors: Cojo Art.com | Eddie Brock, Peter Parker, Spider-Man, Venom |
| 25 | Shadows of the Past | comic story | 22 | script: Howard Mackie; pencils: John Romita Jr.; inks: Scott Hanna; colors: Gregory Wright; letters: Comicraft | Eddie Brock, May Parker, Peter Parker, Spider-Man, Arthur Stacy, Jill Stacy, Paul Stacy, Venom |
| 26 | - | illustration | 1 | letters: typeset | |
| 27 | Cry Venom! Cry Vengeance! | cover reprint (on interior page) | 1 | pencils: John Romita Jr.; inks: Scott Hanna | Eddie Brock, J. Jonah Jameson, Peter Parker, Spider-Man, Venom |
| 28 | Venom Triumphant! | comic story | 23 | script: Howard Mackie; pencils: John Romita Jr.; inks: Scott Hanna; colors: Joe Rosas; letters: Comicraft | Eddie Brock, Carnage, J. Jonah Jameson, Cletus Kasady, May Parker, Peter Parker, Spider-Man, Jill Stacy, Venom, Mary Jane Watson |
| 29 | - | illustration | 1 | letters: typeset | |
| 30 | The Blob Comes to Town -- To Squash a Spider! | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Blob, Fred Dukes, Peter Parker, Spider-Man |
| 31 | Bright Lights ... Bigger City | comic story | 22 | script: Howard Mackie; pencils: John Byrne; inks: John Byrne; colors: Joe Rosas; letters: RS, Comicraft/LA | Blob, Fred Dukes, J. Jonah Jameson, Mary Jane Watson, Peter Parker, Robbie Robertson, Spider-Man, Jill Stacy, Ben Urich |
| 32 | Previously, in "The Eighth Day" | recap | 1 | letters: typeset | |
| 33 | The Eighth Day Part 1: Nothing Can Stop the Juggernaut? Don't Tell Thor! | cover reprint (on interior page) | 0.5 | pencils: John Romita Jr.; inks: Klaus Janson | Juggernaut, Cain Marko, Thor Odinson, Thor |
| 34 | The Eighth Day Part 2 of Four | cover reprint (on interior page) | 0.5 | pencils: Sean Chen; inks: Rob Hunter; colors: Liquid! | Iron Man, Thor Odinson, Tony Stark, Thor |
| 35 | The Eighth Day Part 3 of Four | cover reprint (on interior page) | 1 | pencils: John Romita Jr.; inks: Scott Hanna | Bedlam, Inferno, Iron Man, Olisa Kabaki, Samantha McGee, Thor Odinson, Peter Parker, Spider-Man, Tony Stark, Thor |
| 36 | An Exemplary Day [The Eighth Day Part 3] | comic story | 22 | script: Howard Mackie; pencils: John Romita Jr.; inks: Scott Hanna; colors: Gregory Wright; letters: Richard Starkings, Comicraft's Liz Agraphiotis | Bedlam, Carnivore, Conquest, Decay, Nicolette Giroux, Yoshiro Hachiman, Inferno, Iron Man, J. Jonah Jameson, Edwin Jarvis, Juggernaut, Olisa Kabaki, Bridget Malone, Cain Marko |
| 37 | - | text story | 1 | letters: typeset | |
| 38 | The Eighth Day Part 4 of Four | cover reprint (on interior page) | 1 | pencils: Adam Kubert; inks: Tim Townsend | Bedlam, Carnivore, Conquest, Decay, Nicolette Giroux, Yoshiro Hachiman, Inferno, Juggernaut, Olisa Kabaki, Bridget Malone, Cain Marko, Samantha McGee, Utama Somchart, Stonecutter |
| 39 | Return of the Sinister Six! | cover reprint (on interior page) | 1 | pencils: John Byrne; inks: John Byrne | Eddie Brock, Kraven the Hunter, Alexei Kravinoff, Flint Marko, Peter Parker, Sandman, Spider-Man, Adrian Toomes, Venom, The Vulture |
| 40 | Another Return of the Sinister Six! | comic story | 32 | script: Howard Mackie; pencils: John Byrne; inks: John Beatty, Ramos; colors: Joe Rosas; letters: Richard Starkings, Comicraft, Troy Peteri | Daniel Berkhart, Eddie Brock, Max Dillon, Doctor Octopus, Electro, Kraven the Hunter, Alexei Kravinoff, Flint Marko, Mysterio, Otto Octavius, May Parker, Peter Parker, Sandman, Spider-Man |
| 41 | Let There Be Light! | comic story | 5 | script: Howard Mackie; pencils: Sean Phillips; inks: Sean Phillips; colors: Joe Rosas; letters: Richard Starkings, Comicraft, Troy Peteri | Quentin Beck, Daredevil, Matt Murdock, Mysterio, Mysterio, Peter Parker, Spider-Man |
| 42 | - | illustration | 1 | letters: typeset | |
| 43 | Return of the Sinister Six! Part 2 of 2 | cover reprint (on interior page) | 1 | pencils: John Romita Jr.; inks: Scott Hanna; colors: Joe Rosas | Daniel Berkhart, Eddie Brock, Max Dillon, Electro, Mysterio, Peter Parker, Spider-Man, Venom |
| 44 | Another Return of the Sinister Six | comic story | 28 | script: Howard Mackie; pencils: John Romita Jr.; inks: Scott Hanna; colors: Gregory Wright, Joe Rosas; letters: Richard Starkings, Liz Agraphiotis, Comicraft | Daniel Berkhart, Eddie Brock, Max Dillon, Doctor Octopus, Electro, Kraven the Hunter, Alexei Kravinoff, Flint Marko, Mysterio, Otto Octavius, Peter Parker, Sandman, Spider-Man, Arthur Stacy |
| 45 | - | illustration | 1 | letters: typeset | |
| 46 | Each Day a Grain of Sand Through Life's Hourglass | comic story | 10 | script: Tom Brevoort; pencils: Geof Isherwood; inks: Rod Ramos; colors: John Kalisz; letters: Comicraft, RS, LA | Flint Marko, Flint Marko, Sandman, Bentley Wittman, Wizard |
| 47 | - | illustration | 4 | letters: typeset | |
| 48 | - | promo (ad from the publisher) | 1 | letters: typeset | |
| 49 | - | promo (ad from the publisher) | 1 | pencils: John Byrne; inks: John Byrne | |