| 0 | Spider-Man Vs. Mysterio | cover | 1 | pencils: John Romita Sr.; inks: John Romita Sr.; colors: Veronica Gandini | Spider-Man [Peter Parker]; Mysterio [Quentin Beck] |
| 1 | Spider-Man Vs. Mysterio | credits, title page | 1 | pencils: Jim Mooney, John Romita Jr.; inks: Jim Mooney; colors: Ben Sean | Peter Parker; Mysterio |
| 2 | Spider-Man Vs. Mysterio | credits, title page | 1 | letters: typeset | |
| 3 | Mysterio! | cover reprint (on interior page) | 1 | script: Stan Lee; pencils: Steve Ditko; inks: Steve Ditko; colors: Stan Goldberg; letters: Artie Simek | Spider-Man [Peter Parker]; Mysterio [Quentin Beck] |
| 4 | The Menace of... Mysterio! | comic story | 22 | script: Stan Lee; pencils: Steve Ditko; inks: Steve Ditko; colors: Stan Goldberg; letters: Art Simek | Spider-Man [Peter Parker]; Mysterio [Quentin Beck] (introduction); J. Jonah Jameson; Betty Brant; Flash Thompson; Liz Allan; Aunt May Parker |
| 5 | The Madness of Mysterio! | cover reprint (on interior page) | 1 | pencils: John Romita; inks: John Romita; colors: Stan Goldberg; letters: Sam Rosen | Spider-Man [Peter Parker]; Mysterio [Quentin Beck] |
| 6 | The Madness of Mysterio! | comic story | 20 | script: Stan Lee; pencils: John Romita, Don Heck; inks: Mick Demeo; letters: Art Simek | Spider-Man [Peter Parker]; Mysterio [Quentin Beck]; Anna May Watson; Aunt May Parker; Betty Brant; Captain George Stacy; Gwen Stacy; Harry Osborn; J. Jonah Jameson; Ned Leeds; Robbie Robertson; Green Goblin [Norman Osborn] (cameo) |
| 7 | - | cover reprint (on interior page) | 1 | pencils: John Romita; inks: John Romita | Spider-Man [Peter Parker]; Mysterio [Quentin Beck] |
| 8 | To Squash a Spider! | comic story | 20 | script: Stan Lee; pencils: John Romita; inks: Jim Mooney; letters: Art Simek | Spider-Man [Peter Parker]; May Parker; Anna Watson; Gwen Stacy; George Stacy; J. Jonah Jameson; Robbie Robertson; Betty Brant; Ned Leeds; Randy Robertson; Mysterio [Quentin Beck] |
| 9 | Mysterio Is Back... And This Time He's Not Alone! | cover reprint (on interior page) | 1 | pencils: John Romita; inks: John Romita; letters: Gaspar Saladino | Spider-Man [Peter Parker]; Mysterio [Danny Berkhart]; Doctor Octopus (illusion); Jackal (illusion); Morbius (illusion); Vulture (illusion) |
| 10 | The Man's Name Appears to Be...Mysterio! | comic story | 17 | script: Gerry Conway; pencils: Ross Andru; inks: Frank Giacoia, Dave Hunt; colors: Petra Goldberg; letters: Artie Simek | Spider-Man [Peter Parker]; Mysterio [Danny Berkhart]; Professor Miles Warren; Mary Jane Watson; J. Jonah Jameson; Robbie Robertson; Ned Leeds, Betty Brant; Gwen Stacy (flashback); Green Goblin (illusion); Vulture (illusion); Doctor Octopus (illusion); Molten Man (illusion); Jackal (illusion); Tarant |
| 11 | Mysterio Means Madness! | cover reprint (on interior page) | 1 | pencils: John Romita, Gil Kane; inks: John Romita; letters: Danny Crespi | Mysterio [Danny Berkhart]; Spider-Man [Peter Parker] |
| 12 | Dead Man's Bluff! | comic story | 18 | script: Gerry Conway; pencils: Ross Andru; inks: Frank Giacoia, Dave Hunt; colors: Linda Lessmann; letters: Joe Rosen | Spider-Man [Peter Parker]; Aunt May Parker; Mary Jane Watson; Gloria Grant; J. Jonah Jameson; Robbie Robertson; Betty Brant; Ned Leeds; Gwen Stacy (clone); Mrs. Muggins; Mysterio [Danny Berkhart] (villain); Kingpin (villain, hallucination); Mysterio (villain, hallucination); Jackal (villain, halluci |
| 13 | Alone Against the Aliens! | cover reprint (on interior page) | 1 | pencils: Frank Miller; inks: Joe Rubinstein; letters: Irv Watanabe | Spider-Man [Peter Parker]; Aliens |
| 14 | Dilemma! | comic story | 17 | script: Roger Stern; pencils: Jim Mooney, John Romita Jr.; inks: Jim Mooney; colors: Ben Sean; letters: Jim Novak | Spider-Man (feature, origin); Debra Whitman (guest); Nathan Lubensky (guest); Aunt May (guest); Mysterio (villain); "Aliens" from Amazing Spider-Man (Marvel, 1963 series) #2 (villains); The Smuggler (villain); Uncle Ben (cameo);The Burglar (cameo) |
| 15 | - | cover reprint (on interior page) | 1 | pencils: Frank Miller; inks: Joe Rubinstein | Spider-Man [Peter Parker]; Mysterio; Debra Whitman |
| 16 | Aliens and Illusions! | comic story | 17 | script: Roger Stern; pencils: Marie Severin, Jim Mooney; inks: Jim Mooney; colors: Christie Scheele; letters: Jim Novak | Spider-Man [Peter Parker] (feature); Aunt May (guest); Nathan Lubensky (guest); Debra Whitman (guest); Mysterio (villain); "Aliens" (villains) |
| 17 | - | cover reprint (on interior page) | 1 | pencils: John Romita; inks: John Romita | Spider-Man [Peter Parker] |
| 18 | Prelude: The Spider's Thread | comic story | 6 | script: Howard Mackie; pencils: Alex Saviuk; inks: Sam de la Rosa; colors: Bob Sharen; letters: Rick Parker | Max Shiffman; Trudy Shiffman (illusion generated by Mysterio); Diane; Spider-Man [Peter Parker] (in flashback) |
| 19 | Sleight of Mind! | comic story | 33 | script: Howard Mackie; pencils: Alex Saviuk; inks: Sam de la Rosa; colors: Bob Sharen; letters: Rick Parker | Spider-Man [Peter Parker]; Mysterio; Max Schiffman; Mary Jane Watson Parker; Galactus (illusion); Venom (illusion); Green Goblin (illusion); Hobgoblin (illusion); Demogoblin (illusion); X-Men (illusions); Avengers (illusions); Fantastic Four (illusions) |
| 20 | - | cover reprint (on interior page) | 1 | pencils: John Romita; inks: John Romita | Spider-Man [Peter Parker] |
| 21 | Spider-Man Unmasked | cover reprint (on interior page) | 1 | pencils: Mike Wieringo; inks: Mike Manley; colors: Paul Mounts | Spider-Man [Peter Parker]; Mysterio |
| 22 | I Hate a Mystery, Part 1 of 3 | comic story | 21 | script: Peter David; pencils: Todd Nauck; inks: Robert Campanella, Rodney Ramos; colors: Lee Loughridge; letters: Cory Petit, Virtual Calligraphy | Spider-Man [Peter Parker]; Mary Jane Watson-Parker; Aunt May Parker; Flash Thompson; Miss Arrow; Jeremy; Jo Nady; Mysterio [Francis Klum] (villain) |
| 23 | Spider-Man Unmasked | cover reprint (on interior page) | 1 | pencils: Mike Wieringo; inks: Mike Manley; colors: Paul Mounts | Spider-Man [Peter Parker]; Mysterio |
| 24 | I Hate a Mystery, Part 2 of 3 | comic story | 21 | script: Peter David; pencils: Todd Nauck; inks: Robert Campanella; colors: Lee Loughridge; letters: Cory Petit, Virtual Calligraphy | Spider-Man [Peter Parker]; Mary Jane Watson-Parker; Flash Thompson; Miss Arrow; Jeremy; Roger; Mysterio [Francis Klum] (villain); Mysterio [Daniel Berkhart] (villain); Mysterio [Quentin Beck] (villain) |
| 25 | Spider-Man Unmasked | cover reprint (on interior page) | 1 | pencils: Mike Wieringo; inks: Mike Manley; colors: Paul Mounts | Spider-Man [Peter Parker]; Mysterio |
| 26 | I Hate a Mystery, Part 3 of 3 | comic story | 21 | script: Peter David; pencils: Todd Nauck; inks: Robert Campanella; colors: Lee Loughridge; letters: Cory Petit, Virtual Calligraphy | Spider-Man [Peter Parker]; Flash Thompson; Miss Arrow; Jeremy; Roger; Mysterio [Francis Klum] (villain); Mysterio [Daniel Berkhart] (villain); Mysterio [Quentin Beck] (villain) |
| 27 | - | cover reprint (on interior page) | 1 | pencils: Marcos Martín; inks: Marcos Martín; colors: Javier Rodríguez | Mysterio; Spider-Man [Peter Parker]; Hammerhead; Mister Negative; Silvermane; May Parker; Jonah Jameson |
| 28 | Mysterioso Part 1: Un-Murder Incorporated | comic story | 22 | script: Dan Slott; pencils: Marcos Martín; inks: Marcos Martín; colors: Javier Rodríguez; letters: Joe Caramagna | Spider-Man [Peter Parker]; Maggia [Alberto Karnelli; Eddie Costa; Milo Manfredi; Tony Gallo; Paulo Munoz; Joe Karnelli Jr; Vincenzo Karnelli; Bruno Karnelli; Carmine; Sal (introduction for all); Silvermane]; Hammerhead; Mister Negative; Carlie Cooper; May Parker; Jay Jameson; Ray Cooper (introductio |
| 29 | - | cover reprint (on interior page) | 1 | pencils: Marcos Martín; inks: Marcos Martín; colors: Javier Rodríguez | Spider-Man [Peter Parker] |
| 30 | Mysterioso Part 2: Re-Appearing Act | comic story | 22 | script: Dan Slott; pencils: Marcos Martín; inks: Marcos Martín; colors: Javier Rodríguez; letters: Joe Caramagna | Ray Cooper (also in flashback); Carlie Cooper (also in flashback); Yuri Watanabe (also in flashback); George Stacy (flashback); Maggia [Alberto Karnelli; Eddie Costa; Milo Manfredi; Tony Gallo; Paulo Munoz; Joe Karnelli Jr; Vincenzo Karnelli; Bruno Karnelli; Carmine Karnelli (dies); Sal; Silvermane; |
| 31 | - | cover reprint (on interior page) | 1 | pencils: Marcos Martín; inks: Marcos Martín; colors: Javier Rodríguez | Spider-Man [Peter Parker]; Mysterio |
| 32 | Mysterioso Part 3: Smoke & Mirrors | comic story | 22 | script: Dan Slott; pencils: Marcos Martín, Javier Pulido; inks: Marcos Martín, Javier Pulido; colors: Javier Rodríguez; letters: Joe Caramagna | Carlie Cooper; Ray Cooper; Spider-Man [Peter Parker]; Hammerhead; Dr. Trauma; Mister Negative; Mysterio; Maggia; Silvermane; Yuri Watanabe; Chameleon |
| 33 | Mysterio | character profile | 1 | script: Stan Lee; pencils: Steve Ditko; inks: Steve Ditko; colors: Stan Goldberg; letters: Sam Rosen | Mysterio [Quentin Beck] |
| 34 | - | cover reprint (on interior page) | 1 | pencils: Dwayne Turner; inks: Dwayne Turner | Spider-Man [Peter Parker]; Mysterio [Quentin Beck] |
| 35 | The Madness of Mysterio! | cover reprint (on interior page) | 1 | pencils: John Romita; inks: John Romita; letters: Sam Rosen | Spider-Man [Peter Parker]; Mysterio [Quentin Beck] |
| 36 | Featuring: The Menace of Mysterio! | cover reprint (on interior page) | 1 | pencils: John Romita; inks: John Romita; letters: Danny Crespi | Spider-Man [Peter Parker]; Mysterio [Quentin Beck] |
| 37 | - | cover reprint (on interior page) | 1 | pencils: John Romita Sr.; inks: John Romita Sr. | Spider-Man [Peter Parker]; Mysterio |
| 38 | - | cover reprint (on interior page) | 1 | pencils: Joe Quinones; inks: Joe Quinones | Spider-Man [Peter Parker]; Mysterio |
| 39 | Mysterio (Beck) | character profile | 2 | pencils: Todd Nauck, John Romita Sr.; inks: Todd Nauck, John Romita Sr. | Mysterio [Quentin Beck] |
| 40 | Mysterio (Berkhart) | character profile | 2 | pencils: Todd Nauck, Ross Andru; inks: Todd Nauck, Ross Andru | Mysterio [Daniel Berkhart] |
| 41 | Mysterio (Klum) | character profile | 1 | pencils: Todd Nauck, Terry Dodson; inks: Todd Nauck, Terry Dodson | Mysterio [Francis Klum] |