| 0 | - | cover | 1 | pencils: Giuseppe Camuncoli; inks: John Dell; colors: Edgar Delgado | Spider-Man [Peter Parker] |
| 1 | Title Page & Credits | credits, title page | 2 | letters: typeset | |
| 2 | - | cover reprint (on interior page) | 1 | pencils: Ryan Stegman; inks: Ryan Stegman; colors: Jason Howard | Spider-Man 2099 [Miguel O'Hara] |
| 3 | Running Out of Time | comic story | 20 | script: Dan Slott; pencils: Ryan Stegman; inks: John Livesay; colors: Edgar Delgado; letters: Chris Eliopoulos | Spider-Man [Otto Octavius]; Spider-Man 2099 [Miguel O'Hara] |
| 4 | - | cover reprint (on interior page) | 1 | pencils: Ryan Stegman; inks: Ryan Stegman; colors: Jason Howard | Spider-Man [Otto Octavius]; Spider-Man 2099 [Miguel O'Hara] |
| 5 | Cause & Effect | comic story | 20 | script: Dan Slott; pencils: Ryan Stegman; inks: Livesay; colors: Edgar Delgado; letters: Chris Eliopoulos | Spider-Man [Otto Octavius]; Spider-Man 2099 [Miguel O'Hara] |
| 6 | - | cover reprint (on interior page) | 1 | pencils: Ryan Stegman; inks: Ryan Stegman; colors: Jason Howard | Spider-Man [Otto Octavius]; Spider-Man 2099 [Miguel O'Hara] |
| 7 | Inferiority Complex | comic story | 20 | script: Dan Slott; pencils: Ryan Stegman; inks: John Livesay; colors: Edgar Delgado; letters: Chris Eliopoulos | Spider-Man [Otto Octavius] |
| 8 | - | cover reprint (on interior page) | 1 | pencils: Giuseppe Camuncoli; inks: John Dell; colors: Antonio Fabela | Spider-Man [Otto Octavius]; Black Cat [Felicia Hardy] |
| 9 | Sucker Punch | comic story | 20 | script: Dan Slott; pencils: Giuseppe Camuncoli; inks: John Dell; colors: Antonio Fabela; letters: Chris Eliopoulos | Spider-Man [Otto Octavius] |
| 10 | - | cover reprint (on interior page) | 1 | pencils: Giuseppe Camuncoli; inks: John Dell; colors: Antonio Fabela | Spider-Man [Otto Octavius]; Stunner |
| 11 | What Lies Inside | comic story | 20 | script: Dan Slott; pencils: Giuseppe Camuncoli; inks: John Dell; colors: Antonio Fabela; letters: Chris Eliopoulos | Spider-Man [Otto Octavius]; Stunner |
| 12 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Spider-Man [Otto Octavius] |
| 13 | Darkest Hours Part One: Face to Face | comic story | 20 | script: Dan Slott, Christos Gage; pencils: Humberto Ramos; inks: Victor Olazaba; colors: Edgar Delgado; letters: Chris Eliopoulos | Spider-Man [Otto Octavius] |
| 14 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Victor Olazaba; colors: Edgar Delgado | Venom |
| 15 | Darkest Hours Part Two: Complications | comic story | 20 | script: Dan Slott, Christos Gage; pencils: Humberto Ramos; inks: Victor Olazaba; colors: Edgar Delgado; letters: Chris Eliopoulos | Spider-Man [Otto Octavius]; Venom [Flash Thompson] |
| 16 | - | cover reprint (on interior page) | 0.25 | pencils: Mike McKone; inks: Mike McKone; colors: Paul Mounts | Spider-Man 2099 [Miguel O'Hara]; Spider-Man [Otto Octavius] |
| 17 | - | cover reprint (on interior page) | 0.25 | pencils: Olivier Coipel; inks: Olivier Coipel; colors: Olivier Coipel | Spider-Man 2099 [Miguel O'Hara] |
| 18 | - | cover reprint (on interior page) | 0.5 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones | Spider-Man 2099 [Miguel O'Hara] |
| 19 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Venom |
| 20 | Darkest Hours Part Three: Dark Embrace | comic story | 20 | script: Dan Slott, Christos Gage; pencils: Humberto Ramos; inks: Victor Olazaba; colors: Edgar Delgado, Antonio Fabela, Veronica Gandini; letters: Chris Eliopoulos | Spider-Man [Otto Octavius]; Venom |
| 21 | - | cover reprint (on interior page) | 1 | pencils: Humberto Ramos; inks: Humberto Ramos; colors: Edgar Delgado | Venom |
| 22 | Darkest Hours Part Four: Before the Dawn | comic story | 30 | script: Dan Slott, Christos Gage; pencils: Humberto Ramos; inks: Victor Olazaba; colors: Edgar Delgado, Antonio Fabela, Veronica Gandini; letters: Chris Eliopoulos | Spider-Man [Otto Octavius]; Venom [Flash Thompson] |
| 23 | - | cover reprint (on interior page) | 1 | pencils: Ryan Stegman; inks: Ryan Stegman; colors: Jason Howard | Green Goblin [Norman Osborn]; Hobgoblin [Roderick Kingsley] |
| 24 | Goblin Nation Prelude: The Arena | comic story | 20 | script: Dan Slott; pencils: Humberto Ramos, Javier Rodríguez, Marcos Martín; inks: Victor Olazaba, Álvaro López, Marcos Martín; colors: Edgar Delgado, Javier Rodríguez, Marcos Martín; letters: Chris Eliopoulos | Spider-Man [Otto Octavius] |
| 25 | - | cover reprint (on interior page) | 1 | pencils: J. G. Jones; inks: J. G. Jones; colors: Laura Martin | Spider-Man [Otto Octavius] |
| 26 | Hostage Crisis | comic story | 30 | script: Christos Gage; pencils: Javier Rodríguez; inks: Álvaro López; colors: Javier Rodríguez; letters: Chris Eliopoulos | Spider-Man [Otto Octavius] |
| 27 | - | cover reprint (on interior page) | 0.25 | pencils: J. G. Jones; inks: J. G. Jones; colors: Dave Stewart | Spider-Man 2099 [Miguel O'Hara] |
| 28 | - | cover reprint (on interior page) | 0.25 | pencils: J. G. Jones; inks: J. G. Jones; colors: Dave Stewart | Spider-Man [Otto Octavius]; Spider-Man 2099 [Miguel O'Hara] |
| 29 | - | cover reprint (on interior page) | 0.25 | pencils: Leonel Castellani; inks: Leonel Castellani | Spider-Man (as Lego figure) |
| 30 | - | cover reprint (on interior page) | 0.25 | pencils: Leonel Castellani; inks: Leonel Castellani; colors: Leonel Castellani | Spider-Man (as Lego figure) |
| 31 | - | cover reprint (on interior page) | 1 | pencils: Giuseppe Camuncoli; inks: John Dell; colors: Antonio Fabela | Spider-Man [Otto Octavius] |
| 32 | Cards on the Table | comic story | 20 | script: Dan Slott; pencils: Giuseppe Camuncoli; inks: John Dell; colors: Antonio Fabela; letters: Chris Eliopoulos | Spider-Man [Otto Octavius]; Green Goblin; Jonah Jameson; Peter Parker |
| 33 | - | cover reprint (on interior page) | 0.25 | pencils: Adi Granov; inks: Adi Granov; colors: Adi Granov | Black Cat [Felicia Hardy] |
| 34 | - | cover reprint (on interior page) | 0.25 | pencils: J. Scott Campbell; inks: J. Scott Campbell; colors: Nei Ruffino | Black Cat [Felicia Hardy] |
| 35 | - | cover reprint (on interior page) | 0.5 | pencils: J. Scott Campbell; inks: J. Scott Campbell; colors: Edgar Delgado | Spider-Man [Otto Octavius]; Venom |
| 36 | - | cover reprint (on interior page) | 1 | pencils: Giuseppe Camuncoli; inks: John Dell; colors: Antonio Fabela | Green Goblin |
| 37 | The Fall of Spider-Island | comic story | 20 | script: Dan Slott; pencils: Giuseppe Camuncoli; inks: John Dell; colors: Antonio Fabela; letters: Chris Eliopoulos | Spider-Man [Otto Octavius]; Green Goblin; Jonah Jameson; Peter Parker; Mary Jane Watson |
| 38 | - | cover reprint (on interior page) | 1 | pencils: Giuseppe Camuncoli; inks: John Dell; colors: Antonio Fabela | Spider-Man [Otto Octavius]; Spider-Man 2099 [Miguel O'Hara] |
| 39 | Legs Out from under You | comic story | 20 | script: Dan Slott, Christos Gage; pencils: Giuseppe Camuncoli; inks: John Dell; colors: Antonio Fabela; letters: Chris Eliopoulos | Spider-Man [Otto Octavius]; Spider-Man [Miguel O'Hara]; Green Goblin; Jonah Jameson; Peter Parker; Mary Jane Watson |
| 40 | - | cover reprint (on interior page) | 1 | pencils: Michael Del Mundo; inks: Michael Del Mundo; colors: Michael Del Mundo | Hobgoblin |
| 41 | Blood Ties | comic story | 20 | script: Christos Gage; pencils: Javier Rodríguez; inks: Álvaro López; colors: Javier Rodríguez; letters: Clayton Cowles, VC | Spider-Man [Otto Octavius]; Ben Urich; Norah Winters; Mary Jane Watson; May Parker; Jay Jameson; Robbie Robertson; Sajani Jaffrey; Carlie Cooper; Hobgoblin (villain) |
| 42 | Chasing Ghosts | comic story | 10 | script: Christos Gage; pencils: Philippe Briones; inks: Philippe Briones; colors: Veronica Gandini; letters: Clayton Cowles, VC; editing: Ellie Pyle, Nick Lowe | Wraith; Living Brain; Sajani Jaffrey; Carlie Cooper |
| 43 | - | cover reprint (on interior page) | 1 | pencils: Skottie Young; inks: Skottie Young; colors: Skottie Young | Spider-Man [Otto Octavius]; Venom [Flash Thompson] |
| 44 | - | cover reprint (on interior page) | 1 | pencils: Giuseppe Camuncoli; inks: John Dell; colors: Antonio Fabela | Spider-Man [Otto Octavius] |
| 45 | A Troubled Soul | comic story | 20 | script: Dan Slott, Christos Gage; pencils: Giuseppe Camuncoli; inks: John Dell, Terry Pallot; colors: Antonio Fabela; letters: Chris Eliopoulos | Spider-Man [Otto Octavius]; Spider-Man 2099 [Miguel O'Hara]; J. Jonah Jameson; Spider-Man [Peter Parker]; Captain America (cameo); Iron Man (cameo); Wolverine (cameo); Black Widow (cameo); Spider-Woman (cameo) |
| 46 | - | cover reprint (on interior page) | 0.5 | pencils: Stefano Caselli; inks: Stefano Caselli; colors: Frank Martin | Spider-Man [Otto Octavius]; Venom [Flash Thompson] |
| 47 | - | cover reprint (on interior page) | 0.25 | pencils: J. G. Jones; inks: J. G. Jones; colors: J. G. Jones | Venom |
| 48 | - | cover reprint (on interior page) | 0.25 | pencils: Frank Kozik; inks: Frank Kozik; colors: Frank Kozik | Venom (as Labbit) |
| 49 | - | cover reprint (on interior page) | 1 | pencils: Giuseppe Camuncoli; inks: John Dell; colors: Edgar Delgado | Spider-Man [Peter Parker] |
| 50 | Amazing | comic story | 25 | script: Dan Slott, Christos Gage; pencils: Giuseppe Camuncoli; inks: John Dell, Terry Pallot; colors: Antonio Fabela; letters: Chris Eliopoulos | Spider-Man [Peter Parker]; Spider-Man 2099 [Miguel O'Hara]; J. Jonah Jameson; Avengers [Thor; Iron Man; Wolverine; Spider-Woman; Captain America; Black Widow] (cameo); Green Goblin (villain); Hobgoblin (villain) |
| 51 | Actions Have Consequences | comic story | 15 | script: Christos Gage; pencils: Will Sliney; inks: Will Sliney; colors: Edgar Delgado; letters: Chris Eliopoulos | Peter Parker; Aunt May Parker; Mary Jane Watson; J. Jonah Jameson; Carlie Cooper; Spider-Man |
| 52 | - | cover reprint (on interior page) | 1 | pencils: Mark Brooks; inks: Mark Brooks; colors: Mark Brooks | Spider-Man [Otto Octavius]; Green Goblin |
| 53 | - | cover reprint (on interior page) | 1 | pencils: Jenny Parks; inks: Jenny Parks; colors: Jenny Parks | Spider-Man (as a cat) |
| 54 | - | cover reprint (on interior page) | 1 | pencils: David Marquez; inks: David Marquez; colors: Marte Gracia | Spider-Man [Otto Octavius]; Green Goblin |
| 55 | - | cover reprint (on interior page) | 1 | pencils: Jorge Molina; inks: Jorge Molina; colors: Jorge Molina | Spider-Man [Otto Octavius]; Green Goblin |
| 56 | - | cover reprint (on interior page) | 1 | pencils: J. Scott Campbell; inks: J. Scott Campbell; colors: Edgar Delgado | Black Cat [Felicia Hardy] |
| 57 | - | cover reprint (on interior page) | 1 | pencils: Tim Sale; inks: Tim Sale; colors: Dave Stewart | Captain America [Steve Rogers]; Spider-Man [Peter Parker]; Electro [Maxwell Dillon] |
| 58 | - | cover reprint (on interior page) | 1 | pencils: Kevin Maguire; inks: Kevin Maguire; colors: James Campbell | Spider-Man; Green Goblin |
| 59 | - | cover reprint (on interior page) | 2 | pencils: J. Scott Campbell; inks: J. Scott Campbell; colors: Nei Ruffino | Spider-Man 2099 [Miguel O'Hara]; Spider-Man [Otto Octavius]; Venom; Black Cat [Felicia Hardy]; Green Goblin; Hobgoblin; Mary Jane Watson; Electro [Maxwell Dillon]; Gwen Stacy; Sandman; Chameleon; Doctor Octopus |
| 60 | - | cover reprint (on interior page) | 2 | pencils: J. Scott Campbell; inks: J. Scott Campbell; colors: Nei Ruffino | Superior Spider-Man [Peter Parker; Otto Octavius]; Spider-Man 2099 [Miguel O'Hara] |