| 0 | - | cover | 1 | pencils: Mark Bagley; colors: Transparency Digital | Spider-Man |
| 1 | Title and Credits | credits, title page | 2 | pencils: Mark Bagley; colors: Transparency Digital | |
| 2 | Power & Responsibility [Part One] | comic story | 48 | script: Bill Jemas, Brian Michael Bendis; pencils: Mark Bagley; inks: Art Thibert; colors: Steve Buccellato; letters: Richard Starkings, Comicraft | Peter Parker [Spider-Man; Not in costume this issue] (feature); Aunt May (guest); Uncle Ben (guest); Mary Jane Watson (guest); Flash Thompson (guest); Kong (guest); Harry Osborn (guest); Norman Osborn (villain); Shaw (villain) |
| 3 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; colors: Transparency Digital | Spider-Man |
| 4 | Power & Responsibility [Part Two] | comic story | 26 | script: Bill Jemas, Brian Michael Bendis; pencils: Mark Bagley; inks: Art Thibert; colors: Steve Buccellato; letters: Richard Starkings, Comicraft, Troy Peteri | Spider-Man; GUESTS: Aunt May; Uncle Ben; Mary Jane Watson; Flash Thompson; Kong; Liz Allen |
| 5 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; colors: Transparency Digital | Spider-Man |
| 6 | Power & Responsibility [Part Three] | comic story | 17 | script: Bill Jemas, Brian Michael Bendis; pencils: Mark Bagley; inks: Art Thibert; colors: Marie Javins, Colorgraphix; letters: Richard Starkings, Comicraft, Troy Peteri | Spider-Man; GUESTS: Aunt May; Uncle Ben (Death in Cameo); Mary Jane Watson; Captain Stacy |
| 7 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; colors: Transparency Digital | Spider-Man |
| 8 | Back Cover | promo (ad from the publisher) | 1 | pencils: Mark Bagley; colors: Transparency Digital | Spider-Man |