| 0 | - | cover | 1 | pencils: Mark Bagley; inks: Andy Lanning; colors: Justin Ponsor | May Parker, Peter Parker, Spider-Man, Gwen Stacy, Mary Jane Watson |
| 1 | - | promo (ad from the publisher) | 1 | letters: typeset | |
| 2 | - | credits, title page | 3 | letters: typeset | |
| 3 | Previously in Ultimate Spider-Man: | recap | 1 | letters: typeset | |
| 4 | 1 | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Andy Lanning; colors: Justin Ponsor | May Parker, Peter Parker, Spider-Man, Gwen Stacy, Mary Jane Watson |
| 5 | - | comic story | 21 | script: Brian Michael Bendis; pencils: Mark Bagley; inks: Andy Lanning; colors: Justin Ponsor, Laura Martin; letters: VC's Cory Petit | Nick Fury, Human Torch, J. Jonah Jameson, May Parker, Kitty Pryde, Steve Rogers, The Shroud, Gwen Stacy, Tony Stark, Johnny Storm, Flash Thompson, Mary Jane Watson |
| 6 | 2 | cover reprint (on interior page) | 1 | pencils: Bryan Hitch; inks: Paul Neary; colors: Paul Mounts | Thor Odinson, Thor |
| 7 | - | comic story | 19 | script: Brian Michael Bendis, Jonathan Hickman, Nick Spencer; pencils: Gabriel Hardman, Bryan Hitch, Lee Garbett; inks: Gabriel Hardman, Paul Neary, Roger Bonet; colors: Frank Martin, Paul Mounts, Guru eFX; letters: VC's Cory Petit | Angel, Anna Marie, Cyclops, Gambit, Giant-Man, Thor Odinson, Hela, J. Jonah Jameson, Juggernaut, Remy LeBeau, Logan, Loki, Cain Marko, Nightcrawler |
| 8 | 3 | cover reprint (on interior page) | 1 | pencils: Adam Kubert; inks: Adam Kubert; colors: Frank Martin | Bobby Drake, Human Torch, Iceman, Kitty Pryde, Johnny Storm |
| 9 | - | comic story | 20 | script: Jonathan Hickman, Nick Spencer, Jonathan Hickman; pencils: Steve Kurth, Eric Nguyen, Carlo Pagulayan; inks: Jay Leisten, Eric Nguyen, Jason Paz; colors: Antonio Fabela, Eric Nguyen, Rachelle Rosenberg; letters: VC's Cory Petit, VC's Clayton Cowles | Bruce Banner, Valentina Allegra de Fontaine, Bobby Drake, Nick Fury, Jean Grey, Hulk, J. Jonah Jameson, May Parker, Kitty Pryde, Steve Rogers, Tony Stark, Johnny Storm |
| 10 | 4 | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Andy Lanning; colors: Justin Ponsor | Captain America, Thor Odinson, Iron Man, Miles Morales First, Steve Rogers, Spider-Man First, Tony Stark, Thor |
| 11 | - | comic story | 20 | script: Jonathan Hickman, Nick Spencer, Brian Michael Bendis; pencils: Salvador Larroca, Clayton Crain, Sara Pichelli; inks: Sara Pichelli, Salvador Larroca, Clayton Crain; colors: Frank D'Armata, Justin Ponsor, Clayton Crain; letters: VC's Cory Petit, VC's Clayton Cowles | Captain America, Valerie Cooper, Thor Odinson, Ben Grimm, Human Torch, Invisible Woman, Kangaroo, Miles Morales First, Frank Oliver, Peter Parker, Reed Richards, Susan Storm Richards, Steve Rogers, Spider-Man First |
| 12 | 5 | cover reprint (on interior page) | 1 | pencils: Adam Kubert; inks: Adam Kubert; colors: Justin Ponsor | Victor Creed, Raven Darkhölme, Pietro Maximoff, Wanda Maximoff, Mystique, Quicksilver, Sabretooth, Scarlet Witch |
| 13 | - | comic story | 20 | script: Nick Spencer, Jonathan Hickman; pencils: Luke Ross, Billy Tan; inks: Luke Ross, Billy Tan; colors: Jason Keith, Guru eFX; letters: VC's Cory Petit | Clint Barton, Nick Fury, Pietro Maximoff, Wanda Maximoff, Quicksilver, Scarlet Witch, Jasper Sitwell |
| 14 | - | illustration | 1 | | |
| 15 | 6 | cover reprint (on interior page) | 1 | pencils: Bryan Hitch; inks: Paul Neary; colors: Paul Mounts | Captain America, Steve Rogers |
| 16 | - | comic story | 21 | script: Brian Michael Bendis, Nick Spencer, Jonathan Hickman; pencils: Mark Bagley, Eric Nguyen, Mitch Breitweiser; inks: Andy Lanning, Eric Nguyen, Mitch Breitweiser; colors: Paul Mounts, Eric Nguyen, Mitch Breitweiser, Bettie Breitweiser; letters: VC's Cory Petit | Bobby Drake, Nick Fury, May Parker, Kitty Pryde, Gwen Stacy, Johnny Storm, Mary Jane Watson |
| 17 | #4 Second-Printing Variant | cover reprint (on interior page) | 1 | pencils: Sara Pichelli; inks: Sara Pichelli; colors: Justin Ponsor | Miles Morales First, Spider-Man First |
| 18 | #1-6 Variants | cover reprint (on interior page) | 2 | pencils: Marko Djurdjević; inks: Marko Djurdjević; colors: Marko Djurdjević | |
| 19 | - | illustration | 1 | | |
| 20 | - | promo (ad from the publisher) | 1 | letters: typeset | |
| 21 | - | promo (ad from the publisher) | 1 | pencils: Bryan Hitch; inks: Paul Neary; colors: Paul Mounts | Captain America, Steve Rogers |