| 0 | - | cover | 1 | pencils: Mark Bagley; inks: Mark Bagley | Eddie Brock Jr., Peter Parker, Spider-Man, Venom |
| 1 | - | credits, title page | 1 | pencils: Mark Bagley; inks: Art Thibert; colors: Transparency Digital | Peter Parker, Spider-Man, Venom |
| 2 | - | table of contents | 2 | pencils: Mark Bagley; inks: Art Thibert; colors: Transparency Digital | |
| 3 | Previously in Ultimate Spider-Man: | recap | 1 | pencils: Mark Bagley; inks: Art Thibert, Rodney Ramos; colors: Transparency Digital | |
| 4 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Mark Bagley; editing: Ralph Macchio | Eddie Brock Jr., Venom |
| 5 | Origins | comic story | 21 | script: Brian Michael Bendis; pencils: Mark Bagley; inks: Art Thibert, Rodney Ramos; colors: Transparency Digital; letters: Chris Eliopoulos; editing: Ralph Macchio | Eddie Brock Sr., Eddie Brock Jr., May Parker, Ben Parker, Mary Parker, Peter Parker, Richard Parker, Spider-Man, Gwen Stacy, Venom |
| 6 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Mark Bagley; editing: Ralph Macchio | Peter Parker, Spider-Man, Venom |
| 7 | Inheritance | comic story | 21 | script: Brian Michael Bendis; pencils: Mark Bagley; inks: Art Thibert; colors: Transparency Digital; letters: Chris Eliopoulos; editing: Ralph Macchio | Liz Allan, Eddie Brock Sr., Eddie Brock Jr., Kong, Peter Parker, Richard Parker, Spider-Man, Gwen Stacy, Flash Thompson, Venom, Mary Jane Watson |
| 8 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Mark Bagley; editing: Ralph Macchio | Peter Parker, Spider-Man, Venom |
| 9 | Legacy | comic story | 22 | script: Brian Michael Bendis; pencils: Mark Bagley; inks: Art Thibert; colors: Transparency Digital; letters: Chris Eliopoulos; editing: Ralph Macchio | Doctor Octopus, Eddie Brock Jr., Wilson Fisk, Kingpin, Logan, Otto Octavius, May Parker, Ben Parker, Mary Parker, Peter Parker, Richard Parker, Herman Schultz, Shocker, Spider-Man |
| 10 | - | illustration | 1 | pencils: Mark Bagley; inks: Art Thibert; colors: Transparency Digital | Peter Parker, Spider-Man, Venom |
| 11 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Mark Bagley; editing: Ralph Macchio | Eddie Brock Jr., Peter Parker, Spider-Man, Venom |
| 12 | Today | comic story | 22 | script: Brian Michael Bendis; pencils: Mark Bagley; inks: Art Thibert; colors: Transparency Digital; letters: Chris Eliopoulos; editing: Ralph Macchio | Eddie Brock Jr., Peter Parker, Spider-Man, Gwen Stacy, Venom |
| 13 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Mark Bagley; editing: Ralph Macchio | Eddie Brock Jr., Venom |
| 14 | Still | comic story | 22 | script: Brian Michael Bendis; pencils: Mark Bagley; inks: Art Thibert; colors: Transparency Digital; letters: Chris Eliopoulos; editing: Ralph Macchio | Eddie Brock Jr., Peter Parker, Spider-Man, Venom, Mary Jane Watson |
| 15 | - | illustration | 1 | pencils: Mark Bagley; inks: Art Thibert; colors: Transparency Digital | Peter Parker, Spider-Man, Venom |
| 16 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Mark Bagley; editing: Ralph Macchio | Eddie Brock Jr., Peter Parker, Spider-Man, Venom |
| 17 | Father's Pride | comic story | 22 | script: Brian Michael Bendis; pencils: Mark Bagley; inks: Art Thibert; colors: Transparency Digital; letters: Chris Eliopoulos; editing: Ralph Macchio | Eddie Brock Jr., Peter Parker, Richard Parker, Spider-Man, Venom |
| 18 | - | cover reprint (on interior page) | 1 | pencils: Mark Bagley; inks: Mark Bagley; editing: Ralph Macchio | Peter Parker, Spider-Man |
| 19 | Therapy | comic story | 22 | script: Brian Michael Bendis; pencils: Mark Bagley; inks: Art Thibert; colors: Transparency Digital; letters: Chris Eliopoulos; editing: Ralph Macchio | Curt Connors, Nick Fury, Lizard, Peter Parker, Spider-Man |
| 20 | Venom Arc Outline | text article | 2 | script: Brian Michael Bendis; pencils: Mark Bagley; inks: Art Thibert; colors: Transparency Digital | Eddie Brock Jr., Peter Parker, Spider-Man, Venom, Venom |
| 21 | Spider-Man's Ultimate Villain Gets the Ultimate Treatment | promo (ad from the publisher) | 1 | letters: typeset | |