| 0 | - | cover | 1 | pencils: Gisèle Lagacé; inks: Gisèle Lagacé; colors: Rachelle Rosenberg | Gwenpool; Arcade |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Elsa Charretier; inks: Elsa Charretier; colors: Tamra Bonvillain | Gwenpool |
| 2 | - | comic story | 20 | script: Christopher Hastings; pencils: Myisha Haynes; inks: Myisha Haynes; colors: Rachelle Rosenberg; letters: Clayton Cowles, Virtual Calligraphy | Gwenpool; Blade |
| 3 | - | cover reprint (on interior page) | 1 | pencils: Gisèle Lagacé; inks: Gisèle Lagacé; colors: Rachelle Rosenberg | Gwenpool; Arcade |
| 4 | - | comic story | 20 | script: Christopher Hastings; pencils: Gurihiru Studios; inks: Gurihiru Studios; colors: Gurihiru Studios; letters: Clayton Cowles, Virtual Calligraphy | Gwenpool; Arcade; Batroc; Mega Tony; Terrible Eye; Deadpool [Wade Wilson] |
| 5 | - | cover reprint (on interior page) | 1 | pencils: Gisèle Lagacé; inks: Gisèle Lagacé; colors: Matt Yackey | Gwenpool; Batroc; Arcade |
| 6 | - | comic story | 20 | script: Christopher Hastings; pencils: Gurihiru Studios, Alti Firmansyah; inks: Gurihiru Studios, Alti Firmansyah; colors: Gurihiru Studios, Rachelle Rosenberg; letters: Clayton Cowles, Virtual Calligraphy | Gwenpool; Arcade; Batroc; Deadpool [Wade Wilson]; Terrible Eye; Mega Tony; Walrus |
| 7 | - | cover reprint (on interior page) | 1 | pencils: Paulina Ganucheau; inks: Paulina Ganucheau; colors: Paulina Ganucheau | Gwenpool; Hawkeye [Kate Bishop]; Ghost Rider [Robbie Reyes] |
| 8 | - | comic story | 20 | script: Christopher Hastings; pencils: Myisha Haynes; inks: Myisha Haynes; colors: Rachelle Rosenberg; letters: Clayton Cowles, Virtual Calligraphy | Gwenpool; Hawkeye [Kate Bishop]; Ghost Rider [Robbie Reyes] |
| 9 | - | cover reprint (on interior page) | 1 | pencils: Paulina Ganucheau; inks: Paulina Ganucheau; colors: Paulina Ganucheau | Gwenpool; Hawkeye [Kate Bishop]; Ghost Rider [Robbie Reyes] |
| 10 | - | comic story | 20 | script: Christopher Hastings; pencils: Myisha Haynes; inks: Myisha Haynes; colors: Rachelle Rosenberg; letters: Clayton Cowles, Virtual Calligraphy | Gwenpool; Hawkeye [Kate Bishop]; Ghost Rider [Robbie Reyes] |
| 11 | - | cover reprint (on interior page) | 1 | pencils: Salvador Espin; inks: Salvador Espin; colors: Salvador Espin | Santa Claus; Gwenpool; Punisher [Frank Castle]; Deadpool [Wade Wilson]; Spider-Man [Miles Morales]; Red Skull |
| 12 | Gwenpool's Unbelievable Christmas (a.k.a. the Gwenpool Holiday Special for Real This Time) | comic story | 10 | script: Christopher Hastings; pencils: Myisha Haynes; inks: Myisha Haynes; colors: Rachelle Rosenberg; letters: Clayton Cowles, Virtual Calligraphy | Gwenpool; Batroc; Mega Tony; Terrible Eye; Sub-Mariner; Santa Claus |
| 13 | I Saw Spidey Kissing Galactus, the Bringer of Gifts | comic story | 10 | script: Ryan North; pencils: Nathan Stockman; inks: Nathan Stockman; colors: James Campbell; letters: Clayton Cowles, Virtual Calligraphy | Spider-Man [Miles Morales]; Galactus; Fin Fang Foom; Red Skull; MODOK; Thanos |
| 14 | The War on Pantsgiving | comic story | 10 | script: Karla Pacheco; pencils: Oscar Bazaldúa; inks: Oscar Bazaldúa; colors: Andres Mossa; letters: Travis Lanham | Punisher [Frank Castle]; Fin Fang Foom; Hellcat [Patsy Walker]; Jubilee; Captain Marvel [Carol Danvers]; Spectrum [Monica Rambeau]; Squirrel Girl; Tippy Toe; Deadpool [Wade Wilson]; Ronnie |
| 15 | Happy Hydra Holidays | comic story | 10 | script: Nick Kocher; pencils: Bruno Oliveira; inks: Bruno Oliveira; colors: Rachelle Rosenberg; letters: Travis Lanham | Red Skull; Hydra agents; Hawkeye [Clint Barton]; Adolf Hitler; Thor [Jane Foster]; Iron Man [Tony Stark]; Jared |
| 16 | - | cover reprint (on interior page) | 1 | pencils: Gene Campbell; inks: Gene Campbell; colors: Gene Campbell | Gwenpool |
| 17 | - | cover reprint (on interior page) | 1 | pencils: Yasmine Putri; inks: Yasmine Putri; colors: Yasmine Putri | Gwenpool (as Venom) |
| 18 | - | cover reprint (on interior page) | 1 | pencils: Erica Henderson; inks: Erica Henderson; colors: Erica Henderson | Galactus; Gwenpool; Spider-Man [Miles Morales] |
| 19 | - | cover reprint (on interior page) | 1 | pencils: Chip Zdarsky; inks: Chip Zdarsky; colors: Chip Zdarsky | Gwenpool; Punisher [Frank Castle] |
| 20 | - | cover reprint (on interior page) | 1 | pencils: Ron Lim; inks: Ron Lim; colors: Rachelle Rosenberg | Santa Claus; Gwenpool; Galactus; Spider-Man [Miles Morales] |