| 0 | - | cover | 1 | pencils: Dave Wilkins; inks: Dave Wilkins; colors: Dave Wilkins | Doctor Doom, Victor Von Doom, Emma Frost, Iron Patriot, Norman Osborn |
| 1 | - | cover reprint (on interior page) | 1 | pencils: Bob Layton; inks: Bob Layton | Dr. Doom [Tony Stark] |
| 2 | What If Tony Stark Had Become Doctor Doom? | comic story | 22 | script: Bob Layton, David Michelinie; pencils: Graham Nolan; inks: Mark Pennington; colors: SotoColor; letters: Dave Sharpe | Dr. Doom [Tony Stark]; Iron Man [Victor Von Doom]; Watcher |
| 3 | - | cover reprint (on interior page) | 1 | pencils: Leinil Francis Yu; inks: Leinil Francis Yu; colors: Jason Keith | Wolverine; Daken |
| 4 | Credits and Recap | recap | 1 | pencils: Javier Saltares; inks: Mark Texeira; colors: Jonathan D. Smith | |
| 5 | Wolverine: Father | comic story | 25 | script: Rob Williams; pencils: Greg Tocchini; inks: Greg Tocchini; colors: Chris Sotomayor; letters: VC's Clayton Cowles | Wolverine (death); Daken (death); Winter Soldier [Bucky Barnes] (death); Professor X; Sabretooth |
| 6 | - | cover reprint (on interior page) | 1 | pencils: Phil Jimenez; inks: Phil Jimenez; colors: Frank D'Armata | |
| 7 | What If Spider-Man Killed Kraven the Hunter? | comic story | 22 | script: Mark Sable; pencils: Paul Azaceta; inks: Matt Southworth; colors: Andres Mossa, Nick Dragotta, Javier Rodríguez; letters: VC, Joe Sabino | |
| 8 | - | cover reprint (on interior page) | 1 | pencils: Mike Deodato Jr.; inks: Mike Deodato Jr.; colors: Rain Beredo | Hawkeye [Clint Barton]; Mockingbird; Victoria Hand; Norman Osborn |
| 9 | Credits and Recap | recap | 1 | pencils: Marko Djurdjević; inks: Mark Morales; colors: Marte Gracia | |
| 10 | - | comic story | 22 | script: Jason Henderson; pencils: Sana Takeda; inks: Sana Takeda; colors: Sana Takeda; letters: Dave Sharpe | Avengers [Hawkeye [Clint Barton] (death); Mockingbird; Captain America [Bucky Barnes]; Spider-Man]; GUESTS: Norman Osborn (death); Victoria Hand; CAMEOS: Bullseye (death); Daken (death); Ares |
| 11 | What If Venom... Possessed Deadpool? | cover reprint (on interior page) | 1 | pencils: Skottie Young; inks: Skottie Young; colors: Skottie Young | Venompool [Deadpool; Venom] |
| 12 | Chapter One: 1985 The Man with the M.O.D.O.K. Butt | comic story | 6 | script: Rick Remender; pencils: Shawn Moll; inks: Mark Irwin; colors: Chris Sotomayor; letters: Virtual Calligraphy, Clayton Cowles; editing: Tom Brennan, Stephen Wacker | Venompool [Deadpool; Venom]; Boy Watcher; Galactus; Nova [Frankie Ray]; M.O.D.O.K.; Beyonder; Spider-Man |
| 13 | What If Venom Possessed Deadpool Chapter Two: 1993 Straight Outta Secret Wars XII | comic story | 6 | script: Rick Remender; pencils: Shawn Moll; inks: Mark Irwin; colors: Chris Sotomayor; letters: VC's Clayton Cowles; editing: Thomas Brennan, Stephen Wacker | Venompool [Deadpool; Venom]; The Beyonder; Tony Stark [Iron Man]; Nick Fury; Sentry; The Watcher; CAMEOS: AIM; Fantastic Four [Mr. Fantastic; Invisible Woman; Human Torch; The Thing]; Edwin Jarvis; Iceman; Angel; Gargoyle; Captain America; Thor; Wolverine; The Cockroach; Mummy Moon Knight |
| 14 | What If Venom Possessed Deadpool? Chapter Three | comic story | 6 | script: Rick Remender; pencils: Shawn Moll; inks: Mark Irwin, John Livesay; colors: Chris Sotomayor; letters: VC, Clayton Cowles | |
| 15 | What If Venom Possessed Deadpool? Chapter Four | comic story | 6 | script: Rick Remender; pencils: Shawn Moll; inks: Walden Wong, Scott Hanna; colors: Chris Sotomayor; letters: Virtual Calligraphy, Clayton Cowles; editing: Thomas Brennan, Stephen Wacker | Venompool [Deadpool; Venom]; CAMEOS: Galactus; The Beyonder; Thor; Storm; Rogue; Elektra; Scarlet Witch; Dr. Doom; Ultron; Green Goblin; Magneto; Doc Samson; Hulk; Wolverine |
| 16 | What If? | cover reprint (on interior page) | 2 | pencils: Dave Wilkins; inks: Dave Wilkins; colors: Dave Wilkins | Dr. Doom; Iron Man [Tony Stark]; Emma Frost [White Queen]; Loki; Sentry |
| 17 | What If... Norman Osborn Won the Siege of Asgard? | comic story | 22 | script: Marc Guggenheim; pencils: Dave Wilkins, Lucio Parrillo; inks: Dave Wilkins, Lucio Parrillo; colors: Dave Wilkins, Lucio Parrillo; letters: Dave Lanphear | Dark Avengers [Iron Patriot [Norman Osborn]; Ares; Sentry [The Void]; Spider-Man [Mac Gargan]; Hawkeye [Bullseye]; Ms. Marvel [Karla Sofen; Moonstone]; Wolverine [Daken]]; X-Men [Cyclops; Emma Frost [White Queen]; Wolverine; X-23; Beast; Magneto; Nightcrawler; Namor, the Sub-Mariner]; Iron Man [Tony |
| 18 | Previously in Fantastic Four #48-50 | recap | 1 | pencils: Jack Kirby; inks: Joe Sinnott | |
| 19 | What If I, the Watcher, Killed Galactus? | comic story | 10 | script: Stan Lee; pencils: Dale Eaglesham; inks: Dale Eaglesham; colors: Laura Martin; letters: Todd Klein | Fantastic Four [Mr. Fantastic; Invisible Girl; Human Torch; The Thing]; Galactus (death); Silver Surfer; Uatu, the Watcher; other Watchers |
| 20 | What If? A Retrospective with Roy Thomas | text article | 3 | script: Roy Thomas | |
| 21 | What Was Your Favorite What If? | text article | 2 | script: various; pencils: various; inks: various; colors: various; letters: typeset | |
| 22 | ... What if Bullseye Had Not Killed Elektra? | comic story | 16 | script: Frank Miller; pencils: Frank Miller; inks: Terry Austin; colors: Glynis Wein; letters: Joe Rosen | Daredevil [Matt Murdock]; Elektra; Watcher; Bullseye; Foggy Nelson; Kingpin; Eric Slaughter; Becky Blake |
| 23 | What If? 200 Cover Gallery | cover reprint (on interior page) | 4 | pencils: various; inks: various; colors: various; letters: typeset | |