| 0 | - | cover | 1 | pencils: Johnny Craig; inks: Johnny Craig; colors: Marie Severin | |
| 1 | - | blank page(s) | 1 | | |
| 2 | - | illustration | 1 | | |
| 3 | - | illustration | 1 | | |
| 4 | - | credits, title page | 2 | letters: typeset | |
| 5 | - | table of contents | 2 | letters: typeset | |
| 6 | Introduction | foreword, introduction, preface, afterword | 2 | script: Grant Geissman | |
| 7 | Foreword | foreword, introduction, preface, afterword | 1 | script: John Landis | |
| 8 | - | illustration | 1 | | |
| 9 | Sink-hole! | cover reprint (on interior page) | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper (inset); The Old Witch (inset); The Crypt-Keeper (inset); Aldous Barstow (corpse); Shirley Barstow; Rick Hudson |
| 11 | Sink-Hole! | comic story | 8 | script: Johnny Craig; pencils: Johnny Craig; inks: Johnny Craig; letters: Jim Wroten | The Vault-Keeper (host); Aldous Barstow; Rick Hudson (health inspector); Shirley Barstow (villain, wife of Aldous, death) |
| 12 | Lend Me a Hand! | comic story | 7 | script: Bill Gaines, Al Feldstein; pencils: Jack Davis; inks: Jack Davis; letters: Jim Wroten | The Crypt-Keeper (cameo); Dr. Brown (Dr. Johnstone's assistant); Dr. Brown's nurse (cameo); a drunk (death); Dr. Harold Johnstone (villain, death) |
| 13 | Trap | text story | 2 | script: William M. Gaines | Inspector Mattern |
| 14 | untitled | letters page | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper (cameo) |
| 15 | The Mask of Horror | comic story | 6 | script: Bill Gaines, Al Feldstein; pencils: Jack Kamen; inks: Jack Kamen; letters: Jim Wroten | The Vault-Keeper (cameo); Ken Anders; Ander's fiancee; unnamed costume shop owner; unnamed woman vampire (villain, vampire, death) |
| 16 | Dying to Lose Weight! | comic story | 7 | script: Bill Gaines, Al Feldstein; pencils: Graham Ingels; inks: Graham Ingels; letters: Jim Wroten | The Old Witch (cameo); Mrs. Van Klege (wealthy woman, death); Pierre (dress fitter); Tom Adkins (hen-pecked husband, death); Leena Adkins (Tom's wife); Sally Bates (death); Sally's mother; Charlie Street (death); Dr. Perdo (villain, death) |
| 17 | - | illustration | 1 | | |
| 18 | The Witch's Cauldron | cover reprint (on interior page) | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper (inset); the Old Witch (inset); the Crypt-Keeper (inset) |
| 19 | Two-Fisted Tales | promo (ad from the publisher) | 1 | letters: typeset | |
| 20 | Southern Hospitality! | comic story | 8 | script: Johnny Craig; pencils: Johnny Craig; inks: Johnny Craig; letters: Jim Wroten | The Vault-Keeper (host); Claudia Jackson Scanlon (Arthur's wife); Mr. Jackson (Claudia's father, death); Martha Jackson (Claudia's aunt, death); Sebastian Cornelius Jackson (Claudia's great-grandfather, image only); Abner Scanlon (villain, a gigolo, death) |
| 21 | The Jellyfish! | comic story | 7 | script: Ray Bradbury, Bill Gaines, Al Feldstein; pencils: Jack Davis; inks: Jack Davis; letters: Jim Wroten | The Crypt-Keeper (host); Howard Norton (Charles' brother, business co-owner and chemist); Charles Norton (villain, business co-owner, death) |
| 22 | Two Raps! | text story | 2 | script: William M. Gaines | Melvin Brigham |
| 23 | - | letters page | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper (head view) |
| 24 | Daddy Lost His Head! | comic story | 6 | script: Al Feldstein, Bill Gaines; pencils: Jack Kamen; inks: Jack Kamen; letters: Jim Wroten | The Vault-Keeper (cameo); Martin Blackson; Kathy (his stepdaughter) |
| 25 | Reunion! | comic story | 7 | script: Bill Gaines, Al Feldstein; pencils: Graham Ingels; inks: Graham Ingels; letters: Jim Wroten | The Old Witch (cameo); Waldo Ansley (death); Lillian Ansley (Waldo's wife, death); Roger Kane (death) |
| 26 | - | illustration | 1 | | |
| 27 | The Reluctant Vampire | cover reprint (on interior page) | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper (inset); The Crypt-Keeper (inset); The Old Witch (inset) |
| 28 | Artist of the Issue: Jack Kamen | text article | 1 | pencils: ? (photo); inks: ? (photo); letters: typeset | |
| 29 | About Face! | comic story | 8 | script: Johnny Craig; pencils: Johnny Craig; inks: Johnny Craig; letters: Jim Wroten | The Vault-Keeper (host); Lydia Armstrong (animal trainer); King (lion); Steve (villain, Lydia's chauffeur) |
| 30 | The Reluctant Vampire! | comic story | 7 | script: Al Feldstein; pencils: Jack Davis; inks: Jack Davis; letters: Jim Wroten | The Crypt-Keeper (host); Mr. Cross (blood bank director); Mr. Drink (villain, a vampire, death) |
| 31 | Deception | text story | 2 | script: William M. Gaines | Melton |
| 32 | - | letters page | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper (head view) |
| 33 | Grandma's Ghost!! | comic story | 6 | script: Al Feldstein, Bill Gaines; pencils: Jack Kamen; inks: Jack Kamen; letters: Jim Wroten | The Vault-Keeper (host); Peggy |
| 34 | Revenge is the Nuts! | comic story | 7 | script: William Gaines, Al Feldstein; pencils: Graham Ingels; inks: Graham Ingels; letters: Jim Wroten | The Old Witch (host); Doctor Blackpool |
| 35 | - | illustration | 1 | | |
| 36 | That's A 'Croc' | cover reprint (on interior page) | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper (inset); The Crypt-Keeper (inset); The Old Witch (inset) |
| 37 | Mad Magazine | promo (ad from the publisher) | 1 | letters: typeset | |
| 38 | One Last Fling! | comic story | 8 | script: Johnny Craig; pencils: Johnny Craig; inks: Johnny Craig; letters: Jim Wroten | The Vault-Keeper (host); Olga (villain, Harry's wife, a vampire, death); Harry (knife thrower, death) |
| 39 | That's a 'Croc'! | comic story | 7 | script: Al Feldstein, Bill Gaines; pencils: Howard Larsen; inks: Howard Larsen; letters: Jim Wroten | The Old Witch (host); "Crazy" Coogan (zoo-keeper) |
| 40 | Now or Never! | text story | 2 | script: William M. Gaines | Lt. Edward Cragg |
| 41 | - | letters page | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper [cameo] |
| 42 | Child's Play | comic story | 6 | script: Al Feldstein, Bill Gaines; pencils: Jack Kamen; inks: Jack Kamen; letters: Jim Wroten | The Vault-Keeper (host); Milton Collins; Emma Collins |
| 43 | Trapped! | comic story | 7 | script: Bill Gaines, Al Feldstein; pencils: Jack Davis; inks: Jack Davis; letters: Jim Wroten | The Crypt-Keeper (host); Bud Harrison (hobo, death); Marty (villain) |
| 44 | - | illustration | 1 | | |
| 45 | Frankenstein Monster! | cover reprint (on interior page) | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper (inset); The Crypt-Keeper (inset); The Old Witch (inset); The Frankenstein Monster |
| 46 | Weird Science; Weird Fantasy | promo (ad from the publisher) | 1 | letters: typeset | |
| 47 | Fountains of Youth! | comic story | 8 | script: Johnny Craig; pencils: Johnny Craig; inks: Johnny Craig; letters: Jim Wroten | The Vault-Keeper (host); Kenneth Martin; Eileen Martin (Kenneth's sister, death); Miss Blanchard; Madam DuBois (villain, death) |
| 48 | The Monster in the Ice! | comic story | 7 | script: Al Feldstein, Bill Gaines; pencils: Graham Ingels; inks: Graham Ingels; letters: Jim Wroten | The Old Witch (host); The Frankenstein Monster; Gerald Dawson and Herbert Campbell (geologists) |
| 49 | Choice | text story | 2 | script: William M. Gaines | |
| 50 | - | letters page | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper (head view) |
| 51 | Gone...Fishing! | comic story | 6 | script: Al Feldstein; pencils: Jack Davis; inks: Jack Davis; letters: Jim Wroten | The Crypt-Keeper (host); Maxwell Larkin (death); Steven |
| 52 | What the Dog Dragged In! | comic story | 7 | script: Ray Bradbury, Al Feldstein; pencils: Jack Kamen; inks: Jack Kamen; letters: Jim Wroten | The Vault-Keeper (host); Betty Marsh; Jerry the dog; Roger Cartwright |
| 53 | - | illustration | 1 | | |
| 54 | Staired in Horror | cover reprint (on interior page) | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper (inset); The Old Witch (inset); The Crypt-Keeper (inset) |
| 55 | [The EC] Artist of the Issue | text article | 1 | pencils: ? (photograph); inks: ? (photograph); letters: typeset | Graham Ingels (photo) |
| 56 | A Stitch in Time! | comic story | 8 | script: Johnny Craig; pencils: Johnny Craig; inks: Johnny Craig; colors: Marie Severin; letters: Jim Wroten | The Vault-Keeper (host); sweatshop workers; Mr. Lasch (villain, sweatshop owner, death) |
| 57 | 99 44/100% Pure Horror! | comic story | 7 | script: Bill Gaines, Al Feldstein; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin; letters: Jim Wroten | The Crypt-Keeper (host); Benny Anderson (soap factory manager, death, in flashback); Mr. Hudson (soap factory owner, in flashback); Ernie Mattson (villain, death) |
| 58 | Superstition! | text story | 2 | script: William M. Gaines | Matison |
| 59 | - | letters page | 1 | pencils: Johnny Craig; inks: Johnny Craig | The Vault-Keeper (head view) |
| 60 | Dead Wait! | comic story | 6 | script: Bill Gaines, Al Feldstein; pencils: Jack Davis; inks: Jack Davis; colors: Marie Severin; letters: Jim Wroten | The Vault-Keeper (host); Emil Duval (plantation owner, death); Kulu (villain, native); 'Red' Buckley (villain, death) |
| 61 | Staired... in Horror! | comic story | 7 | script: Al Feldstein, Bill Gaines; pencils: Graham Ingels; inks: Graham Ingels; colors: Marie Severin; letters: Jim Wroten | The Old Witch (host); Irma Leechman; Robert Hornsby |
| 62 | EC Archives | promo (ad from the publisher) | 3 | letters: typeset | |
| 63 | - | blank page(s) | 1 | | |
| 64 | Back Cover | cover | 1 | letters: typeset | |